-
Something wrong with this record ?
A new microcystin producing Nostoc strain discovered in broad toxicological screening of non-planktic Nostocaceae (cyanobacteria)
A. Kust, P. Urajová, P. Hrouzek, DL. Vu, K. Čapková, L. Štenclová, K. Řeháková, E. Kozlíková-Zapomělová, O. Lepšová-Skácelová, A. Lukešová, J. Mareš,
Language English Country England, Great Britain
Document type Journal Article
- MeSH
- Phylogeny MeSH
- Microcystins chemistry metabolism MeSH
- Nostoc genetics metabolism MeSH
- Publication type
- Journal Article MeSH
Benthic cyanobacteria recognized as producers of natural products, including cyanotoxins, have been neglected for systematic toxicological studies. Thus, we have performed a broad study investigating cyanotoxin potential of 311 non-planktic nostocacean representatives combining molecular and chemical analyses. Out of these, a single strain Nostoc sp. Treb K1/5, was identified as a new microcystin producer. Microcystins [Asp3]MC-YR, [Asp3]MC-FR, [Asp3]MC-HtyR and Ala-Leu/Ile-Asp-Arg-Adda-Glu-Mdha are reported for the first time from the genus Nostoc. All the studied strains were also analyzed for the occurrence of nodularins, cylindrospermopsin and (homo)anatoxin-a, yet no novel producer has been discovered. Our findings indicate rare occurrence of the common cyanotoxins in non-planktic nostocaceae which is in contrast with frequent reports of cyanotoxin producers among phylogenetically closely related planktic cyanobacteria.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19000729
- 003
- CZ-PrNML
- 005
- 20190121113117.0
- 007
- ta
- 008
- 190107s2018 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.toxicon.2018.05.007 $2 doi
- 035 __
- $a (PubMed)29772212
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Kust, Andreja $u The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic; Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic.
- 245 12
- $a A new microcystin producing Nostoc strain discovered in broad toxicological screening of non-planktic Nostocaceae (cyanobacteria) / $c A. Kust, P. Urajová, P. Hrouzek, DL. Vu, K. Čapková, L. Štenclová, K. Řeháková, E. Kozlíková-Zapomělová, O. Lepšová-Skácelová, A. Lukešová, J. Mareš,
- 520 9_
- $a Benthic cyanobacteria recognized as producers of natural products, including cyanotoxins, have been neglected for systematic toxicological studies. Thus, we have performed a broad study investigating cyanotoxin potential of 311 non-planktic nostocacean representatives combining molecular and chemical analyses. Out of these, a single strain Nostoc sp. Treb K1/5, was identified as a new microcystin producer. Microcystins [Asp3]MC-YR, [Asp3]MC-FR, [Asp3]MC-HtyR and Ala-Leu/Ile-Asp-Arg-Adda-Glu-Mdha are reported for the first time from the genus Nostoc. All the studied strains were also analyzed for the occurrence of nodularins, cylindrospermopsin and (homo)anatoxin-a, yet no novel producer has been discovered. Our findings indicate rare occurrence of the common cyanotoxins in non-planktic nostocaceae which is in contrast with frequent reports of cyanotoxin producers among phylogenetically closely related planktic cyanobacteria.
- 650 _2
- $a mikrocystiny $x chemie $x metabolismus $7 D052998
- 650 _2
- $a Nostoc $x genetika $x metabolismus $7 D046937
- 650 _2
- $a fylogeneze $7 D010802
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Urajová, Petra $u Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic.
- 700 1_
- $a Hrouzek, Pavel $u Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Vu, Dai Long $u Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic.
- 700 1_
- $a Čapková, Kateřina $u The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Štenclová, Lenka $u The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Řeháková, Klára $u The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Kozlíková-Zapomělová, Eliška $u The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Lepšová-Skácelová, Olga $u Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Lukešová, Alena $u Institute of Soil Biology, The Czech Academy of Sciences, Biology Centre, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic.
- 700 1_
- $a Mareš, Jan $u The Czech Academy of Sciences, Biology Centre, Institute of Hydrobiology, Na Sádkách 7, CZ-37005, České Budějovice, Czech Republic; Centre Algatech, Institute of Microbiology, Czech Academy of Sciences, Opatovický mlýn, CZ-379 81, Třeboň, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, CZ-37005, České Budějovice, Czech Republic. Electronic address: jan.mares@centrum.cz.
- 773 0_
- $w MED00004539 $t Toxicon official journal of the International Society on Toxinology $x 1879-3150 $g Roč. 150, č. - (2018), s. 66-73
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29772212 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190107 $b ABA008
- 991 __
- $a 20190121113335 $b ABA008
- 999 __
- $a ok $b bmc $g 1364748 $s 1038852
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 150 $c - $d 66-73 $e 20180526 $i 1879-3150 $m Toxicon $n Toxicon $x MED00004539
- LZP __
- $a Pubmed-20190107
