A new microcystin producing Nostoc strain discovered in broad toxicological screening of non-planktic Nostocaceae (cyanobacteria)
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
29772212
DOI
10.1016/j.toxicon.2018.05.007
PII: S0041-0101(18)30192-2
Knihovny.cz E-resources
- Keywords
- Anabaena, Cyanotoxins, Heterocytous cyanobacteria, Microcystin, Non-planktic Nostocaceae, Nostoc,
- MeSH
- Phylogeny MeSH
- Microcystins chemistry metabolism MeSH
- Nostoc genetics metabolism MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Microcystins MeSH
Benthic cyanobacteria recognized as producers of natural products, including cyanotoxins, have been neglected for systematic toxicological studies. Thus, we have performed a broad study investigating cyanotoxin potential of 311 non-planktic nostocacean representatives combining molecular and chemical analyses. Out of these, a single strain Nostoc sp. Treb K1/5, was identified as a new microcystin producer. Microcystins [Asp3]MC-YR, [Asp3]MC-FR, [Asp3]MC-HtyR and Ala-Leu/Ile-Asp-Arg-Adda-Glu-Mdha are reported for the first time from the genus Nostoc. All the studied strains were also analyzed for the occurrence of nodularins, cylindrospermopsin and (homo)anatoxin-a, yet no novel producer has been discovered. Our findings indicate rare occurrence of the common cyanotoxins in non-planktic nostocaceae which is in contrast with frequent reports of cyanotoxin producers among phylogenetically closely related planktic cyanobacteria.
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