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STAT3, stem cells, cancer stem cells and p63
M. Galoczova, P. Coates, B. Vojtesek,
Language English Country England, Great Britain
Document type Journal Article, Review
NLK
BioMedCentral
from 2006-03-01
BioMedCentral Open Access
from 2006
Directory of Open Access Journals
from 2013
PubMed Central
from 2006
Europe PubMed Central
from 2006
ProQuest Central
from 2016-01-01
Health & Medicine (ProQuest)
from 2016-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2006
Springer Nature OA/Free Journals
from 2006-03-01
- MeSH
- Phosphorylation MeSH
- Humans MeSH
- Human Embryonic Stem Cells metabolism MeSH
- Methylation MeSH
- MicroRNAs metabolism MeSH
- Mouse Embryonic Stem Cells metabolism MeSH
- Mice MeSH
- Neoplastic Stem Cells metabolism MeSH
- Tumor Suppressor Proteins chemistry metabolism MeSH
- Neoplasms metabolism MeSH
- Cellular Reprogramming MeSH
- STAT3 Transcription Factor chemistry metabolism MeSH
- Transcription Factors chemistry metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its role in stem cell and cancer stem cell properties and highlights recent reports about its relationship to p63.
References provided by Crossref.org
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