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STAT3, stem cells, cancer stem cells and p63
M. Galoczova, P. Coates, B. Vojtesek,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
NLK
BioMedCentral
od 2006-03-01
BioMedCentral Open Access
od 2006
Directory of Open Access Journals
od 2013
PubMed Central
od 2006
Europe PubMed Central
od 2006
ProQuest Central
od 2016-01-01
Health & Medicine (ProQuest)
od 2016-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2006
Springer Nature OA/Free Journals
od 2006-03-01
- MeSH
- fosforylace MeSH
- lidé MeSH
- lidské embryonální kmenové buňky metabolismus MeSH
- metylace MeSH
- mikro RNA metabolismus MeSH
- myší embryonální kmenové buňky metabolismus MeSH
- myši MeSH
- nádorové kmenové buňky metabolismus MeSH
- nádorové supresorové proteiny chemie metabolismus MeSH
- nádory metabolismus MeSH
- přeprogramování buněk MeSH
- transkripční faktor STAT3 chemie metabolismus MeSH
- transkripční faktory chemie metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its role in stem cell and cancer stem cell properties and highlights recent reports about its relationship to p63.
Citace poskytuje Crossref.org
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