Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The possible critical role of T-cell help in DSA-mediated graft loss

C. Süsal, A. Slavcev, L. Pham, M. Zeier, C. Morath,

. 2018 ; 31 (6) : 577-584. [pub] 20180308

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19000936

Grantová podpora
NV16-27477A MZ0 CEP - Centrální evidence projektů

In this review, we discuss a possible central role of T-cell help in severe forms of graft damage mediated by donor-specific HLA antibodies (DSA). Some kidney transplant recipients with pretransplant DSA show a high graft failure rate, whereas in other patients DSA do not harm the transplanted kidney and in most cases, disappear shortly after transplantation. Analyzing 80 desensitized highly immunized kidney transplant recipients and another multicenter cohort of 385 patients with pretransplant HLA antibodies, we reported recently that an ongoing T-cell help from an activated immune system, as measured by an increased level of soluble CD30 in serum, might be necessary for the DSA to exert a deleterious effect. Patients positive for both pretransplant DSA and sCD30 appear to require special measures, such as the elimination of DSA from the circulation, potent immunosuppression, good HLA-matching, and intense post-transplant monitoring, whereas exclusion of DSA-positive patients from transplantation in the absence of high sCD30 may not be justified in all cases, even if the pretransplant DSA are strong and complement-activating.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19000936
003      
CZ-PrNML
005      
20230207113011.0
007      
ta
008      
190107s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/tri.13126 $2 doi
035    __
$a (PubMed)29405445
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Süsal, Caner $u Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
245    14
$a The possible critical role of T-cell help in DSA-mediated graft loss / $c C. Süsal, A. Slavcev, L. Pham, M. Zeier, C. Morath,
520    9_
$a In this review, we discuss a possible central role of T-cell help in severe forms of graft damage mediated by donor-specific HLA antibodies (DSA). Some kidney transplant recipients with pretransplant DSA show a high graft failure rate, whereas in other patients DSA do not harm the transplanted kidney and in most cases, disappear shortly after transplantation. Analyzing 80 desensitized highly immunized kidney transplant recipients and another multicenter cohort of 385 patients with pretransplant HLA antibodies, we reported recently that an ongoing T-cell help from an activated immune system, as measured by an increased level of soluble CD30 in serum, might be necessary for the DSA to exert a deleterious effect. Patients positive for both pretransplant DSA and sCD30 appear to require special measures, such as the elimination of DSA from the circulation, potent immunosuppression, good HLA-matching, and intense post-transplant monitoring, whereas exclusion of DSA-positive patients from transplantation in the absence of high sCD30 may not be justified in all cases, even if the pretransplant DSA are strong and complement-activating.
650    _2
$a zvířata $7 D000818
650    _2
$a protilátky $x imunologie $7 D000906
650    _2
$a kohortové studie $7 D015331
650    _2
$a komplement $7 D003165
650    _2
$a rejekce štěpu $x imunologie $7 D006084
650    _2
$a přežívání štěpu $x imunologie $7 D006085
650    _2
$a HLA antigeny $x imunologie $7 D006680
650    _2
$a lidé $7 D006801
650    _2
$a imunosupresiva $7 D007166
650    _2
$a isoprotilátky $x krev $7 D007518
650    _2
$a antigen Ki-1 $x imunologie $7 D017730
650    _2
$a transplantace ledvin $7 D016030
650    _2
$a myši $7 D051379
650    _2
$a renální insuficience $x krev $x imunologie $7 D051437
650    _2
$a T-lymfocyty $x imunologie $7 D013601
650    _2
$a dárci tkání $7 D014019
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Slavcev, Antonij $u Department of Immunogenetics, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic.
700    1_
$a Pham, Lien $u Institute of Immunology, University of Heidelberg, Heidelberg, Germany.
700    1_
$a Zeier, Martin $u Division of Nephrology, University of Heidelberg, Heidelberg, Germany. $7 xx0281649
700    1_
$a Morath, Christian $u Division of Nephrology, University of Heidelberg, Heidelberg, Germany.
773    0_
$w MED00004553 $t Transplant international $x 1432-2277 $g Roč. 31, č. 6 (2018), s. 577-584
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29405445 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20230207113007 $b ABA008
999    __
$a ok $b bmc $g 1364905 $s 1039059
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 31 $c 6 $d 577-584 $e 20180308 $i 1432-2277 $m Transplant international $n Transpl Int $x MED00004553
GRA    __
$a NV16-27477A $p MZ0
LZP    __
$a Pubmed-20190107

Najít záznam

Citační ukazatele

Možnosti archivace