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Chemokine receptors
A. Gibejová
Acta Universitatis Palackianae Olomucensis Facultatis medicae. Biomedical papers.
2000 ;
143 (143) :
9-18.
Language English Country Czech Republic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Persistent link
https://www.medvik.cz/link/bmc19007741
- MeSH
- Cell Differentiation physiology MeSH
- Humans MeSH
- Ligands MeSH
- Mice, Knockout genetics MeSH
- Mice MeSH
- Polymorphism, Genetic MeSH
- Receptors, Chemokine genetics metabolism physiology MeSH
- T-Lymphocytes cytology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Chemokines mediate their multiple effects by binding to a variety of specific receptors, that comprise a subfamily of rhodopsin-like, 7-transmembrane domain receptors, coupled to G proteins. Some of these receptors serve as coreceptors for HIV, some of them could be expressed as markers for T lymphocyte functional differentiation. This review aims at summarising data on chemokine receptors, their function in vivo, their target cells and it also mentions association of chemokine receptor polymorphisms with human disease.
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