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Ketoconazole-resistant mutants of Microsporum gypseum. II. Characteristics of mutants
K. Lenhart, A. Merkunová, D. Walterová, J. Latinák, M. Kozený,
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Odkazy
PubMed
2530848
Knihovny.cz E-zdroje
- MeSH
- antibiotická rezistence MeSH
- ergosterol metabolismus MeSH
- ketokonazol farmakologie MeSH
- klotrimazol farmakologie MeSH
- Microsporum účinky léků genetika metabolismus MeSH
- mikonazol farmakologie MeSH
- mutace * MeSH
- Publikační typ
- časopisecké články MeSH
The presented study deals with the properties of two wild strains of dermatophyte Microsporum gypseum and of eleven mutants resistant to ketoconazole. The growth rate of spontaneous mutants is greater than that of the wild strain, the group of UV-induced mutants manifests in general lower growth rate. The resistance level varies in the interval 1.1-1.6 (spontaneous mutants), resp. 2.7-5.5 (UV-induced mutants). The phenomenon of cross-resistance to other imidazole drugs (miconazole, clotrimazole) has been observed in mutants. There is further given the characteristic of ergosterol synthesis influence by the three used antifungal drugs. The data obtained are discussed from the point of view of possible biochemical processes resulting in the formation of resistance to ketoconazole.
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