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Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins
MV. Pogorelyy, AA. Minervina, MP. Touzel, AL. Sycheva, EA. Komech, EI. Kovalenko, GG. Karganova, ES. Egorov, AY. Komkov, DM. Chudakov, IZ. Mamedov, T. Mora, AM. Walczak, YB. Lebedev,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1915
Freely Accessible Science Journals
od 1915 do Před 6 měsíci
PubMed Central
od 1915 do Před 6 měsíci
Europe PubMed Central
od 1915 do Před 6 měsíci
Open Access Digital Library
od 1915-01-15
Open Access Digital Library
od 1915-01-01
PubMed
30459272
DOI
10.1073/pnas.1809642115
Knihovny.cz E-zdroje
- MeSH
- antigeny virové imunologie MeSH
- dárci tkání MeSH
- dvojčata monozygotní MeSH
- imunizace metody MeSH
- lidé MeSH
- receptory antigenů T-buněk imunologie MeSH
- T-lymfocyty imunologie MeSH
- vakcína proti žluté zimnici imunologie MeSH
- vakcinace metody MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data. We applied this framework to data from three pairs of identical twins immunized with the yellow fever vaccine. We identified 600 to 1,700 responding TCRs in each donor and validated them using three independent assays. While the responding TCRs were mostly private, albeit with higher overlap between twins, they could be well-predicted using a classifier based on sequence similarity. Our method can also be applied to samples obtained postinfection, making it suitable for systematic discovery of new infection-specific TCRs in the clinic.
Citace poskytuje Crossref.org
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- $a Pogorelyy, Mikhail V $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. Department of Molecular Technologies, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
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- $a Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins / $c MV. Pogorelyy, AA. Minervina, MP. Touzel, AL. Sycheva, EA. Komech, EI. Kovalenko, GG. Karganova, ES. Egorov, AY. Komkov, DM. Chudakov, IZ. Mamedov, T. Mora, AM. Walczak, YB. Lebedev,
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- $a Minervina, Anastasia A $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
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- $a Komech, Ekaterina A $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. Department of Molecular Technologies, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
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- $a Kovalenko, Elena I $u Department of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia.
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- $a Karganova, Galina G $u Laboratory of Biology of Arboviruses, Chumakov Institute of Poliomyelitis and Viral Encephalitides, 142782 Moscow, Russia. Department of Virology, Sechenov First Moscow State Medical University, 119146 Moscow, Russia.
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- $a Egorov, Evgeniy S $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. Department of Molecular Technologies, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.
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- $a Komkov, Alexander Yu $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. Laboratory of Cytogenetics and Molecular Genetics, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, 117198 Moscow, Russia.
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- $a Chudakov, Dmitriy M $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia. Department of Molecular Technologies, Pirogov Russian National Research Medical University, 117997 Moscow, Russia. Center for Data-Intensive Biomedicine and Biotechnology, Skoltech, 121205 Moscow, Russia. Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic.
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- $a Mora, Thierry $u Laboratoire de Physique Statistique, CNRS, Sorbonne Université, Université Paris-Diderot, École Normale Supérieure (PSL), 75005 Paris, France; tmora@lps.ens.fr awalczak@lpt.ens.fr lebedev_yb@ibch.ru.
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- $a Walczak, Aleksandra M $u Laboratoire de Physique Théorique, CNRS, Sorbonne Université, École Normale Supérieure (PSL), 75005 Paris, France; tmora@lps.ens.fr awalczak@lpt.ens.fr lebedev_yb@ibch.ru.
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