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Immune Evasion, a Potential Mechanism of Trichothecenes: New Insights into Negative Immune Regulations

Q. Wu, W. Wu, TCC. Franca, V. Jacevic, X. Wang, K. Kuca,

. 2018 ; 19 (11) : . [pub] 20181024

Jazyk angličtina Země Švýcarsko

Typ dokumentu úvodníky, úvodní články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012228

Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled "Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins" for the International Journal of Molecular Sciences (IJMS). Researchers are encouraged to share their latest interesting findings with the readers of IJMS.

Citace poskytuje Crossref.org

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$a Wu, Qinghua $u College of Life Science, Yangtze University, Jinzhou 434025, China. wqh212@hotmail.com.
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$a Days ago, the Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". This news has increased the attention on immunotoxicity and immune evasion mechanisms, which are once again hot research topics. Actually, increasing lines of evidence show that trichothecene mycotoxins have a strong immunosuppressive effect. These mycotoxins suppress the host immunity and make them more sensitive to the infection of pathogens, including bacteria and viruses. However, the underlying mechanism(s) in this context is still poorly understood. Interestingly, recent work showed that an immune evasion mechanism might be involved in trichothecene immunotoxicity. In this work, we discuss the potential immune evasion mechanism in trichothecene immunotoxicity. More importantly, under these circumstances, we are pleased to compile a Special Issue entitled "Biochemistry, Molecular Biology, and Toxicology of Natural and Synthetic Toxins" for the International Journal of Molecular Sciences (IJMS). Researchers are encouraged to share their latest interesting findings with the readers of IJMS.
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$a Wu, Wenda $u College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China. wuwenda@njau.edu.cn.
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$a Franca, Tanos C C $u Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Praça General Tiburcio 80, Rio de Janeiro 22290-270, RJ, Brazil. tanosfranca@gmail.com. Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 500 03 Hradec Kralove, Czech Republic. tanosfranca@gmail.com.
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$a Jacevic, Vesna $u Department of Experimental Toxicology and Pharmacology, National Poison Control Center, Military Medical Academy, 11 Crnotravska St, 11 000 Belgrade, Republic of Serbia. v_jacevic@yahoo.com. Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, 1 Pavla Jurišića-Šturma St, Belgrade 11000, Republic of Serbia. v_jacevic@yahoo.com. Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03 Hradec Kralove, Czech Republic. v_jacevic@yahoo.com.
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$a Wang, Xu $u National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues, Huazhong Agricultural University, Wuhan 430070, China. wangxu@mail.hzau.edu.cn.
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$a Kuca, Kamil $u Department of Chemistry, Faculty of Science, University of Hradec Kralove, 500 03 Hradec Kralove, Czech Republic. kamil.kuca@uhk.cz.
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