• Je něco špatně v tomto záznamu ?

PLP1 and CNTN1 gene variation modulates the microstructure of human white matter in the corpus callosum

C. Anderson, WM. Gerding, C. Fraenz, C. Schlüter, P. Friedrich, M. Raane, L. Arning, JT. Epplen, O. Güntürkün, C. Beste, E. Genç, S. Ocklenburg,

. 2018 ; 223 (8) : 3875-3887. [pub] 20180809

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012481
E-zdroje Online Plný text

NLK ProQuest Central od 2007-07-01 do Před 1 rokem
Medline Complete (EBSCOhost) od 2007-07-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 2007-07-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2007-07-01 do Před 1 rokem
Psychology Database (ProQuest) od 1997-01-01 do Před 1 rokem

Odkazy

PubMed 30094605
DOI 10.1007/s00429-018-1729-7
Knihovny.cz E-zdroje

The corpus callosum is the brain's largest commissural fiber tract and is crucial for interhemispheric integration of neural information. Despite the high relevance of the corpus callosum for several cognitive systems, the molecular determinants of callosal microstructure are largely unknown. Recently, it was shown that genetic variations in the myelin-related proteolipid 1 gene PLP1 and the axon guidance related contactin 1 gene CNTN1 were associated with differences in interhemispheric integration at the behavioral level. Here, we used an innovative new diffusion neuroimaging technique called neurite orientation dispersion and density imaging (NODDI) to quantify axonal morphology in subsections of the corpus callosum and link them to genetic variation in PLP1 and CNTN1. In a cohort of 263 healthy human adults, we found that polymorphisms in both PLP1 and CNTN1 were significantly associated with callosal microstructure. Importantly, we found a double dissociation between gene function and neuroimaging variables. Our results suggest that genetic variation in the myelin-related gene PLP1 impacts white matter microstructure in the corpus callosum, possibly by affecting myelin structure. In contrast, genetic variation in the axon guidance related gene CNTN1 impacts axon density in the corpus callosum. These findings suggest that PLP1 and CNTN1 gene variations modulate specific aspects of callosal microstructure that are in line with their gene function.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19012481
003      
CZ-PrNML
005      
20190411094124.0
007      
ta
008      
190405s2018 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s00429-018-1729-7 $2 doi
035    __
$a (PubMed)30094605
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Anderson, Catrona $u Department of Psychology, University of Otago, P. O. Box 56, Dunedin, New Zealand. cat.anderson@otago.ac.nz. Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany. cat.anderson@otago.ac.nz.
245    10
$a PLP1 and CNTN1 gene variation modulates the microstructure of human white matter in the corpus callosum / $c C. Anderson, WM. Gerding, C. Fraenz, C. Schlüter, P. Friedrich, M. Raane, L. Arning, JT. Epplen, O. Güntürkün, C. Beste, E. Genç, S. Ocklenburg,
520    9_
$a The corpus callosum is the brain's largest commissural fiber tract and is crucial for interhemispheric integration of neural information. Despite the high relevance of the corpus callosum for several cognitive systems, the molecular determinants of callosal microstructure are largely unknown. Recently, it was shown that genetic variations in the myelin-related proteolipid 1 gene PLP1 and the axon guidance related contactin 1 gene CNTN1 were associated with differences in interhemispheric integration at the behavioral level. Here, we used an innovative new diffusion neuroimaging technique called neurite orientation dispersion and density imaging (NODDI) to quantify axonal morphology in subsections of the corpus callosum and link them to genetic variation in PLP1 and CNTN1. In a cohort of 263 healthy human adults, we found that polymorphisms in both PLP1 and CNTN1 were significantly associated with callosal microstructure. Importantly, we found a double dissociation between gene function and neuroimaging variables. Our results suggest that genetic variation in the myelin-related gene PLP1 impacts white matter microstructure in the corpus callosum, possibly by affecting myelin structure. In contrast, genetic variation in the axon guidance related gene CNTN1 impacts axon density in the corpus callosum. These findings suggest that PLP1 and CNTN1 gene variations modulate specific aspects of callosal microstructure that are in line with their gene function.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a kontaktin 1 $x genetika $x fyziologie $7 D058967
650    _2
$a corpus callosum $x anatomie a histologie $7 D003337
650    _2
$a difuzní magnetická rezonance $x metody $7 D038524
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a genotyp $7 D005838
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a myelinový proteolipidový protein $x genetika $x fyziologie $7 D018991
650    _2
$a myelinová pochva $x genetika $7 D009186
650    12
$a neurity $7 D016501
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a bílá hmota $x anatomie a histologie $7 D066127
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Gerding, Wanda M $u Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Fraenz, Christoph $u Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Schlüter, Caroline $u Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Friedrich, Patrick $u Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Raane, Maximilian $u Faculty of Health, ZBAF, University of Witten/Herdecke, Witten, Germany.
700    1_
$a Arning, Larissa $u Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Epplen, Jörg T $u Department of Human Genetics, Ruhr-University Bochum, Bochum, Germany. Faculty of Health, ZBAF, University of Witten/Herdecke, Witten, Germany.
700    1_
$a Güntürkün, Onur $u Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Beste, Christian $u Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany. Experimental Neurobiology, National Institute of Mental Health, Topolova 748, 25067, Klecany, Czech Republic.
700    1_
$a Genç, Erhan $u Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
700    1_
$a Ocklenburg, Sebastian $u Institute of Cognitive Neuroscience, Biopsychology, Department of Psychology, Ruhr-University Bochum, Bochum, Germany.
773    0_
$w MED00172985 $t Brain structure & function $x 1863-2661 $g Roč. 223, č. 8 (2018), s. 3875-3887
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30094605 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20190411094141 $b ABA008
999    __
$a ok $b bmc $g 1391791 $s 1050786
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 223 $c 8 $d 3875-3887 $e 20180809 $i 1863-2661 $m Brain structure & function $n Brain Struct Funct $x MED00172985
LZP    __
$a Pubmed-20190405
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace