Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on MK-801-induced schizophrenia models

O. Mutlu, T. Páleníček, N. Pinterová, K. Šíchová, J. Horáček, K. Holubová, C. Höschl, A. Stuchlík, F. Erden, K. Valeš,

. 2018 ; 32 (6) : 589-602. [pub] 20180627

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19012626

The adipokinetic and red pigment-concentrating hormone (AKH/RPCH) family of peptides controls fat, carbohydrate, and protein metabolism in insects. In our previous study, we showed that AKH possesses antidepressant, anxiolytic, and analgesic effects, causes hyperlocomotion, and exerts neuroprotective effects and increased brain neurotrophic factors in mice. The aim of this study was to investigate the effects of Anax imperator AKH (Ani-AKH), Libellula auripennis AKH (Lia-AKH), and Phormia-Terra hypertrehalosemic hormone (Pht-HrTH) on MK-801-induced memory deterioration in the active allothetic place avoidance test (AAPA) and MK-801-induced sensorimotor gating deficit in the prepulse inhibition test (PPI). In the AAPA task, Long-Evans rats were treated with Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), Pht-HrTH (2 mg/kg), MK-801 (0.15 mg/kg), and the combination of MK-801 with the hormones subchronically. In the prepulse inhibition test, Wistar albino rats were treated with Ani-AKH (1 mg/kg), Lia-AKH (1 mg/kg), Pht-HrTH (1 mg/kg), MK-801 (0.1 mg/kg), or the combination of MK-801 with hormones acutely before the test. In our study, Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), and Pht-HrTH (2 mg/kg) reversed MK-801 (0.15 mg/kg)-induced cognitive memory impairment effects in the AAPA task. Lia-AKH (1 mg/kg) significantly potentiated the MK-801-induced PPI disruption, while Ani-AKH (1 mg/kg) partially potentiated the impairment caused by MK-801, and Pht-HrTH did not modify the effect of MK-801. In conclusion, AKH had no effect in sensorimotor gating deficits in the PPI test in schizophrenia model while AKH improved memory in the schizophrenia model of MK-801.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19012626
003      
CZ-PrNML
005      
20190411131630.0
007      
ta
008      
190405s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1111/fcp.12386 $2 doi
035    __
$a (PubMed)29863789
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Mutlu, Oguz $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic. Pharmacology Department, Kocaeli University Medical Faculty, Kocaeli, 41380, Turkey.
245    10
$a Effects of the adipokinetic hormone/red pigment-concentrating hormone (AKH/RPCH) family of peptides on MK-801-induced schizophrenia models / $c O. Mutlu, T. Páleníček, N. Pinterová, K. Šíchová, J. Horáček, K. Holubová, C. Höschl, A. Stuchlík, F. Erden, K. Valeš,
520    9_
$a The adipokinetic and red pigment-concentrating hormone (AKH/RPCH) family of peptides controls fat, carbohydrate, and protein metabolism in insects. In our previous study, we showed that AKH possesses antidepressant, anxiolytic, and analgesic effects, causes hyperlocomotion, and exerts neuroprotective effects and increased brain neurotrophic factors in mice. The aim of this study was to investigate the effects of Anax imperator AKH (Ani-AKH), Libellula auripennis AKH (Lia-AKH), and Phormia-Terra hypertrehalosemic hormone (Pht-HrTH) on MK-801-induced memory deterioration in the active allothetic place avoidance test (AAPA) and MK-801-induced sensorimotor gating deficit in the prepulse inhibition test (PPI). In the AAPA task, Long-Evans rats were treated with Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), Pht-HrTH (2 mg/kg), MK-801 (0.15 mg/kg), and the combination of MK-801 with the hormones subchronically. In the prepulse inhibition test, Wistar albino rats were treated with Ani-AKH (1 mg/kg), Lia-AKH (1 mg/kg), Pht-HrTH (1 mg/kg), MK-801 (0.1 mg/kg), or the combination of MK-801 with hormones acutely before the test. In our study, Ani-AKH (2 mg/kg), Lia-AKH (2 mg/kg), and Pht-HrTH (2 mg/kg) reversed MK-801 (0.15 mg/kg)-induced cognitive memory impairment effects in the AAPA task. Lia-AKH (1 mg/kg) significantly potentiated the MK-801-induced PPI disruption, while Ani-AKH (1 mg/kg) partially potentiated the impairment caused by MK-801, and Pht-HrTH did not modify the effect of MK-801. In conclusion, AKH had no effect in sensorimotor gating deficits in the PPI test in schizophrenia model while AKH improved memory in the schizophrenia model of MK-801.
650    _2
$a zvířata $7 D000818
650    _2
$a anxiolytika $x farmakologie $7 D014151
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a dizocilpinmaleát $x farmakologie $7 D016291
650    _2
$a hmyzí hormony $x farmakologie $7 D007301
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a paměť $x účinky léků $7 D008568
650    _2
$a poruchy paměti $x chemicky indukované $x farmakoterapie $7 D008569
650    _2
$a neuropeptidy $x farmakologie $7 D009479
650    _2
$a neuroprotektivní látky $7 D018696
650    _2
$a oligopeptidy $x farmakologie $7 D009842
650    _2
$a peptidy $x farmakologie $7 D010455
650    _2
$a kyselina pyrrolidonkarboxylová $x analogy a deriváty $x farmakologie $7 D011761
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Long-Evans $7 D020318
650    _2
$a potkani Wistar $7 D017208
650    _2
$a schizofrenie $x chemicky indukované $x farmakoterapie $7 D012559
655    _2
$a časopisecké články $7 D016428
700    1_
$a Páleníček, Tomáš $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic.
700    1_
$a Pinterová, Nikola $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic.
700    1_
$a Šíchová, Klára $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic.
700    1_
$a Horáček, Jiří $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic.
700    1_
$a Holubová, Kristina $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic. Institute of Physiology, Academy of Sciences of the Czech Republic v.v.i, videnska 1083, Prague 4, 14220, Czech Republic.
700    1_
$a Höschl, Cyril $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic.
700    1_
$a Stuchlík, Aleš $u Institute of Physiology, Academy of Sciences of the Czech Republic v.v.i, videnska 1083, Prague 4, 14220, Czech Republic.
700    1_
$a Erden, Faruk $u Pharmacology Department, Kocaeli University Medical Faculty, Kocaeli, 41380, Turkey.
700    1_
$a Valeš, Karel $u National Institute of Mental Health, Topolova 748, Klecany, 250 67, Czech Republic. Institute of Physiology, Academy of Sciences of the Czech Republic v.v.i, videnska 1083, Prague 4, 14220, Czech Republic.
773    0_
$w MED00001866 $t Fundamental & clinical pharmacology $x 1472-8206 $g Roč. 32, č. 6 (2018), s. 589-602
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29863789 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20190411131647 $b ABA008
999    __
$a ok $b bmc $g 1391936 $s 1050931
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 32 $c 6 $d 589-602 $e 20180627 $i 1472-8206 $m Fundamental & clinical pharmacology $n Fundam Clin Pharmacol $x MED00001866
LZP    __
$a Pubmed-20190405
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace