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The MLL recombinome of acute leukemias in 2017
C. Meyer, T. Burmeister, D. Gröger, G. Tsaur, L. Fechina, A. Renneville, R. Sutton, NC. Venn, M. Emerenciano, MS. Pombo-de-Oliveira, C. Barbieri Blunck, B. Almeida Lopes, J. Zuna, J. Trka, P. Ballerini, H. Lapillonne, M. De Braekeleer, G....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Nursing & Allied Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
28701730
DOI
10.1038/leu.2017.213
Knihovny.cz E-zdroje
- MeSH
- akutní lymfatická leukemie genetika MeSH
- akutní myeloidní leukemie genetika MeSH
- chromozomální aberace MeSH
- dítě MeSH
- dospělí MeSH
- fúzní onkogenní proteiny genetika MeSH
- genová přestavba genetika MeSH
- histonlysin-N-methyltransferasa genetika MeSH
- kojenec MeSH
- lidé MeSH
- protoonkogenní protein MLL genetika MeSH
- translokace genetická genetika MeSH
- zlomy chromozomů MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant, pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained from 2345 acute leukemia patients. Genomic breakpoints within the MLL gene and the involved translocation partner genes (TPGs) were determined and 11 novel TPGs were identified. Thus, a total of 135 different MLL rearrangements have been identified so far, of which 94 TPGs are now characterized at the molecular level. In all, 35 out of these 94 TPGs occur recurrently, but only 9 specific gene fusions account for more than 90% of all illegitimate recombinations of the MLL gene. We observed an age-dependent breakpoint shift with breakpoints localizing within MLL intron 11 associated with acute lymphoblastic leukemia and younger patients, while breakpoints in MLL intron 9 predominate in AML or older patients. The molecular characterization of MLL breakpoints suggests different etiologies in the different age groups and allows the correlation of functional domains of the MLL gene with clinical outcome. This study provides a comprehensive analysis of the MLL recombinome in acute leukemia and demonstrates that the establishment of patient-specific chromosomal fusion sites allows the design of specific PCR primers for minimal residual disease analyses for all patients.
Biological Hematology AP HP A Trousseau Pierre et Marie Curie University Paris France
Bristol Genetics Laboratory Pathology Sciences Southmead Hospital North Bristol NHS Trust Bristol UK
Center for Diagnostic University Medical Center Hamburg Eppendorf Hamburg Germany
Centro Ricerca Tettamanti Clinica Pediatrica Univ Milano Bicocca Monza Italy
Charité Department of Hematology Oncology and Tumorimmunology Berlin Germany
Children's Cancer Institute Australia Uinversity of NSW Sydney Sydney New South Wales Australia
CHU Purpan Laboratoire d'Hématologie Toulouse France
Department of Clinical Immunology University Hospital Rigshospitalet Copenhagen Denmark
Department of Experimental Pathology and Cytology Institute of Pathology Giessen Germany
Department of Genetics AP HP Robert Debré Paris Diderot University Paris France
Department of Human Genetics Hannover Medical School Hanover Germany
Department of Laboratory Medicine Inje University College of Medicine Busan Korea
Department of Laboratory Medicine School of Medicine Kyung Hee University Seoul Korea
Department of Microbiology and Immunology Medical University of Silesia Zabrze Poland
Department of Oncology University Children's Hospital Zurich Zurich Switzerland
Department of Pediatric Hematology and Oncology Medical University of Silesia Zabrze Poland
Department of Pediatrics Jena University Hospital Jena Germany
Department of Pediatrics MHH Hanover Germany
Department of Pediatrics Portuguese Institute of Oncology of Lisbon Lisbon Portugal
Department of Pediatrics University Medical Centre Schleswig Holstein Kiel Germany
Erasmus MC Department of Immunology Rotterdam The Netherlands
Hemato Oncology Laboratory UIPM Portuguese Institute of Oncology of Lisbon Lisbon Portugal
Hématologie Biologique CHU de Brest and INSERM U1078 Université de Bretagne Occidentale Brest France
INSERM UMR S 1172 Cancer Research Institute of Lille Lille France
Laboratoire d'hématologie AP HP Saint Louis Paris Diderot University Paris France
Laboratory of Clinical Genetics Fimlab Laboratories Tampere Finland
Laboratory of Hematology Biology and Pathology Center CHRU of Lille
Northern Institute for Cancer Research Newcastle University Newcastle upon Tyne UK
Citace poskytuje Crossref.org
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