-
Something wrong with this record ?
The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression
M. Samec, A. Liskova, P. Kubatka, S. Uramova, P. Zubor, SM. Samuel, A. Zulli, M. Pec, T. Bielik, K. Biringer, E. Kudela, J. Benacka, M. Adamek, L. Rodrigo, R. Ciccocioppo, TK. Kwon, D. Baranenko, P. Kruzliak, D. Büsselberg,
Language English Country Germany
Document type Journal Article, Review
Grant support
VEGA 1/0136/19
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
VEGA 1/0124/17
Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
Grant 08-08
Russian Science Support Foundation
NLK
ProQuest Central
from 1997-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2003-04-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-01-01 to 1 year ago
Public Health Database (ProQuest)
from 1997-01-01 to 1 year ago
ROAD: Directory of Open Access Scholarly Resources
from 1997
- MeSH
- Antineoplastic Agents, Phytogenic administration & dosage pharmacology MeSH
- Carcinogenesis drug effects genetics MeSH
- Humans MeSH
- MicroRNAs biosynthesis genetics MeSH
- Neoplasms drug therapy genetics pathology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
PURPOSE: Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis. RESULTS: This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research. CONCLUSIONS: Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
Department of Immunology School of Medicine Keimyung University Dalseo Gu Daegu Korea
Faculty of Health Science and Social Work Trnava University Trnava Slovakia
Faculty of Medicine Central University Hospital of Asturias University of Oviedo Oviedo Spain
Institute for Health and Sport Victoria University Melbourne Australia
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19027607
- 003
- CZ-PrNML
- 005
- 20210219152153.0
- 007
- ta
- 008
- 190813s2019 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s00432-019-02940-0 $2 doi
- 035 __
- $a (PubMed)31127362
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Samec, Marek $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
- 245 14
- $a The role of dietary phytochemicals in the carcinogenesis via the modulation of miRNA expression / $c M. Samec, A. Liskova, P. Kubatka, S. Uramova, P. Zubor, SM. Samuel, A. Zulli, M. Pec, T. Bielik, K. Biringer, E. Kudela, J. Benacka, M. Adamek, L. Rodrigo, R. Ciccocioppo, TK. Kwon, D. Baranenko, P. Kruzliak, D. Büsselberg,
- 520 9_
- $a PURPOSE: Phytochemicals are naturally occurring plant-derived compounds and some of them have the potential to serve as anticancer drugs. Based on recent evidence, aberrantly regulated expression of microRNAs (miRNAs) is closely associated with malignancy. MicroRNAs are characterized as small non-coding RNAs functioning as posttranscriptional regulators of gene expression. Accordingly, miRNAs regulate various target genes, some of which are involved in the process of carcinogenesis. RESULTS: This comprehensive review emphasizes the anticancer potential of phytochemicals, either isolated or in combination, mediated by miRNAs. The ability to modulate the expression of miRNAs demonstrates their importance as regulators of tumorigenesis. Phytochemicals as anticancer agents targeting miRNAs are widely studied in preclinical in vitro and in vivo research. Unfortunately, their anticancer efficacy in targeting miRNAs is less investigated in clinical research. CONCLUSIONS: Significant anticancer properties of phytochemicals as regulators of miRNA expression have been proven, but more studies investigating their clinical relevance are needed.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a fytogenní protinádorové látky $x aplikace a dávkování $x farmakologie $7 D000972
- 650 _2
- $a karcinogeneze $x účinky léků $x genetika $7 D063646
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mikro RNA $x biosyntéza $x genetika $7 D035683
- 650 _2
- $a nádory $x farmakoterapie $x genetika $x patologie $7 D009369
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Liskova, Alena $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
- 700 1_
- $a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 03601, Martin, Slovak Republic. kubatka@jfmed.uniba.sk. Division of Oncology, Department of Experimental Carcinogenesis, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia. kubatka@jfmed.uniba.sk.
- 700 1_
- $a Uramova, Sona $u Division of Oncology, Department of Experimental Carcinogenesis, Jessenius Faculty of Medicine, Biomedical Center Martin, Comenius University in Bratislava, Martin, Slovakia.
- 700 1_
- $a Žúbor, Pavol, $d 1975- $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. $7 xx0117542
- 700 1_
- $a Samuel, Samson Mathews $u Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar.
- 700 1_
- $a Zulli, Anthony $u Institute for Health and Sport, Victoria University, Melbourne, Australia.
- 700 1_
- $a Pec, Martin $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Mala Hora 4, 03601, Martin, Slovak Republic.
- 700 1_
- $a Bielik, Tibor $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
- 700 1_
- $a Biringer, Kamil $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
- 700 1_
- $a Kudela, Erik $u Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
- 700 1_
- $a Benacka, Jozef $u Faculty of Health Science and Social Work, Trnava University, Trnava, Slovakia.
- 700 1_
- $a Adamek, Mariusz $u Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland.
- 700 1_
- $a Rodrigo, Luis $u Faculty of Medicine, Central University Hospital of Asturias (HUCA), University of Oviedo, Oviedo, Spain.
- 700 1_
- $a Ciccocioppo, Rachele $u Gastroenterology Unit, Department of Medicine, AOUI Policlinico G.B. Rossi, University of Verona, Verona, Italy.
- 700 1_
- $a Kwon, Taeg Kyu $u Department of Immunology, School of Medicine, Keimyung University, Dalseo-Gu, Daegu, Korea.
- 700 1_
- $a Baranenko, Denis $u International Research Centre "Biotechnologies of the Third Millennium", ITMO University, Saint-Petersburg, Russian Federation.
- 700 1_
- $a Kruzliak, Peter $u 2nd Department of Surgery, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic. kruzliakpeter@gmail.com. Department of Internal Medicine, Brothers of Mercy Hospital, Polni 553/3, 63900, Brno, Czech Republic. kruzliakpeter@gmail.com.
- 700 1_
- $a Büsselberg, Dietrich $u Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City, Qatar Foundation, P.O. Box 24144, Doha, Qatar. dib2015@qatar-med.cornell.edu.
- 773 0_
- $w MED00009972 $t Journal of cancer research and clinical oncology $x 1432-1335 $g Roč. 145, č. 7 (2019), s. 1665-1679
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31127362 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190813 $b ABA008
- 991 __
- $a 20210219152151 $b ABA008
- 999 __
- $a ok $b bmc $g 1432756 $s 1066067
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 145 $c 7 $d 1665-1679 $e 20190524 $i 1432-1335 $m Journal of cancer research and clinical oncology $n J Cancer Res Clin Oncol $x MED00009972
- GRA __
- $a VEGA 1/0136/19 $p Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
- GRA __
- $a VEGA 1/0124/17 $p Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
- GRA __
- $a Grant 08-08 $p Russian Science Support Foundation
- LZP __
- $a Pubmed-20190813
