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Genetic diversity of the potentially therapeutic tapeworm Hymenolepis diminuta (Cestoda: Cyclophyllidea)

L. Řežábková, J. Brabec, M. Jirků, M. Dellerba, R. Kuchta, D. Modrý, W. Parker, K. Jirků Pomajbíková,

. 2019 ; 71 (-) : 121-125. [pub] 20190411

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19027658

The cestode Hymenolepis diminuta is highly prevalent in wild rat populations and has also been observed rarely in humans, generally causing no apparent harm. The organism has been studied for decades in the laboratory, and its colonization of laboratory rats has recently been shown as protective against some inflammation-associated disorders. Recently, H. diminuta has become a leading candidate for helminth therapy, an emerging method of "biota enrichment" used to treat or prevent inflammatory diseases of humans in Western society. While most of the experimental isolates of H. diminuta are identified based on typical morphological features, hymenolepidid tapeworms may represent complexes of cryptic species as detected by molecular sequence data. In the present study, we explored the diversity of laboratory-kept strains using partial sequences of two genes (lsrDNA and cox1) and determined that H. diminuta isolates currently considered for therapeutic purposes in the US and Europe belong to a single, genetically nearly uniform lineage, showing only little genetic deviation from wild-caught isolates.

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$a Genetic diversity of the potentially therapeutic tapeworm Hymenolepis diminuta (Cestoda: Cyclophyllidea) / $c L. Řežábková, J. Brabec, M. Jirků, M. Dellerba, R. Kuchta, D. Modrý, W. Parker, K. Jirků Pomajbíková,
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$a The cestode Hymenolepis diminuta is highly prevalent in wild rat populations and has also been observed rarely in humans, generally causing no apparent harm. The organism has been studied for decades in the laboratory, and its colonization of laboratory rats has recently been shown as protective against some inflammation-associated disorders. Recently, H. diminuta has become a leading candidate for helminth therapy, an emerging method of "biota enrichment" used to treat or prevent inflammatory diseases of humans in Western society. While most of the experimental isolates of H. diminuta are identified based on typical morphological features, hymenolepidid tapeworms may represent complexes of cryptic species as detected by molecular sequence data. In the present study, we explored the diversity of laboratory-kept strains using partial sequences of two genes (lsrDNA and cox1) and determined that H. diminuta isolates currently considered for therapeutic purposes in the US and Europe belong to a single, genetically nearly uniform lineage, showing only little genetic deviation from wild-caught isolates.
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$a Brabec, Jan $u Biology Centre, Czech Academy of Sciences, Institute of Parasitology, Branišovská 31, České Budějovice 370 05, Czech Republic; Natural History Museum of Geneva, P.O. Box 6134, CH-1211 Geneva, Switzerland.
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$a Modrý, David $u Biology Centre, Czech Academy of Sciences, Institute of Parasitology, Branišovská 31, České Budějovice 370 05, Czech Republic; Department of Pathology and Parasitology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1/3, Brno 621 42, Czech Republic.
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$a Parker, William $u Department of Surgery, Duke University School of Medicine, NC, USA.
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