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Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours
M. Vozdova, S. Kubickova, P. Fictum, J. Fröhlich, F. Jelinek, J. Rubes,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
- MeSH
- frekvence genu MeSH
- kožní mastocytóza genetika patologie veterinární MeSH
- mutace * MeSH
- nádorový supresorový protein p53 genetika MeSH
- nádory kůže genetika patologie veterinární MeSH
- nemoci psů genetika patologie MeSH
- prognóza MeSH
- protoonkogenní proteiny c-kit genetika MeSH
- psi MeSH
- stupeň nádoru veterinární MeSH
- zvířata MeSH
- Check Tag
- psi MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Cutaneous mast cell tumours (MCT) are among the most frequent malignancies in dogs. Their clinical behaviour is highly variable and, with the exception of mutations in the c-kit gene, little is known about their genetic aetiology. The mutational status of the c-kit exons 8, 9 and 11, and exons 5-8 of the TP53 gene was analysed to find markers for molecular stratification of MCTs and predictors of clinical outcome. Mutations in the c-kit gene were detected in 19.5% (n = 8/41) samples and their presence was significantly associated with the high histopathological grade (P = 0.038). Mutations in the DNA binding domain of the TP53 gene were found in 14.6% (n = 6/41) of the analysed MCTs, and their frequency was similar in low and high grade MCTs (P > 0.05). TP53 mutations were not useful prognostic factors in this sample of canine cutaneous MCTs.
Citace poskytuje Crossref.org
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