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Self-assembly of chlorin-e6 on γ-Fe2O3 nanoparticles: Application for larvicidal activity against Aedes aegypti

M. Magro, S. Bramuzzo, D. Baratella, J. Ugolotti, G. Zoppellaro, G. Chemello, I. Olivotto, C. Ballarin, G. Radaelli, B. Arcaro, M. De Liguoro, O. Coppellotti, L. Guidolin, J. de Almeida Roger, E. Bonaiuto, R. Zboril, F. Vianello,

. 2019 ; 194 (-) : 21-31. [pub] 20190313

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19027698

Aedes aegypti mosquitos are widespread vectors of several diseases and their control is of primary importance for biological and environmental reasons, and novel safe insecticides are highly desirable. An eco-friendly photosensitizing magnetic nanocarrier with larvicidal effects on Aedes aegypti was proposed. The innovative core-shell hybrid nanomaterial was synthesized by combining peculiar magnetic nanoparticles (called Surface Active Maghemite Nanoparticles - SAMNs, the core) and chlorin-e6 as photosensitizer (constituting the shell) via self-assembly in water. The hybrid nanomaterial (SAMN@chlorin) was extensively characterized and tested for the photocidal activity on larvae of Aedes aegypti. The SAMN@chlorin core-shell nanohybrid did not present any toxic effect in the dark, but, upon light exposure, showed a higher photocidal activity than free chlorin-e6. Moreover, the eco-toxicity of SAMN@chlorin was determined in adults and neonates of Daphnia magna, where delayed toxicity was observed only after prolonged (≥4 h) exposure to intense light, on the green alga Pseudokirchneriella subcapitata and on the duckweed Lemna minor on which no adverse effects were observed. The high colloidal stability, the physico-chemical robustness and the magnetic drivability of the core-shell SAMN@chlorin nanohybrid, accompanied by the high photocidal activity on Aedes aegypti larvae and reduced environmental concerns, can be proposed as a safe alternative to conventional insecticides.

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$a Magro, Massimiliano $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy; Department of Physical Chemistry, Regional Centre of Advanced Technologies and Materials, Palacky University, Slechtitelu 11, 78371 Olomouc, Czech Republic.
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$a Self-assembly of chlorin-e6 on γ-Fe2O3 nanoparticles: Application for larvicidal activity against Aedes aegypti / $c M. Magro, S. Bramuzzo, D. Baratella, J. Ugolotti, G. Zoppellaro, G. Chemello, I. Olivotto, C. Ballarin, G. Radaelli, B. Arcaro, M. De Liguoro, O. Coppellotti, L. Guidolin, J. de Almeida Roger, E. Bonaiuto, R. Zboril, F. Vianello,
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$a Aedes aegypti mosquitos are widespread vectors of several diseases and their control is of primary importance for biological and environmental reasons, and novel safe insecticides are highly desirable. An eco-friendly photosensitizing magnetic nanocarrier with larvicidal effects on Aedes aegypti was proposed. The innovative core-shell hybrid nanomaterial was synthesized by combining peculiar magnetic nanoparticles (called Surface Active Maghemite Nanoparticles - SAMNs, the core) and chlorin-e6 as photosensitizer (constituting the shell) via self-assembly in water. The hybrid nanomaterial (SAMN@chlorin) was extensively characterized and tested for the photocidal activity on larvae of Aedes aegypti. The SAMN@chlorin core-shell nanohybrid did not present any toxic effect in the dark, but, upon light exposure, showed a higher photocidal activity than free chlorin-e6. Moreover, the eco-toxicity of SAMN@chlorin was determined in adults and neonates of Daphnia magna, where delayed toxicity was observed only after prolonged (≥4 h) exposure to intense light, on the green alga Pseudokirchneriella subcapitata and on the duckweed Lemna minor on which no adverse effects were observed. The high colloidal stability, the physico-chemical robustness and the magnetic drivability of the core-shell SAMN@chlorin nanohybrid, accompanied by the high photocidal activity on Aedes aegypti larvae and reduced environmental concerns, can be proposed as a safe alternative to conventional insecticides.
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$a Bramuzzo, Simone $u Department of Biology, University of Padua, via U. Bassi 58/b, 35121 Padua, Italy.
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$a Ugolotti, Juri $u Department of Physical Chemistry, Regional Centre of Advanced Technologies and Materials, Palacky University, Slechtitelu 11, 78371 Olomouc, Czech Republic.
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$a Zoppellaro, Giorgio $u Department of Physical Chemistry, Regional Centre of Advanced Technologies and Materials, Palacky University, Slechtitelu 11, 78371 Olomouc, Czech Republic.
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$a Chemello, Giulia $u Department of Life and Environmental Sciences, Polo Montedago, Marche Polytechnic University, via Brecce Bianche 12, 60131 Ancona, Italy.
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$a Olivotto, Ike $u Department of Life and Environmental Sciences, Polo Montedago, Marche Polytechnic University, via Brecce Bianche 12, 60131 Ancona, Italy.
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$a Ballarin, Cristina $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.
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$a Radaelli, Giuseppe $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.
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$a Arcaro, Beatrice $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.
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$a De Liguoro, Marco $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.
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$a Coppellotti, Olimpia $u Department of Biology, University of Padua, via U. Bassi 58/b, 35121 Padua, Italy.
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$a Guidolin, Laura $u Department of Biology, University of Padua, via U. Bassi 58/b, 35121 Padua, Italy.
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$a de Almeida Roger, Jessica $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.
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$a Bonaiuto, Emanuela $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy.
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$a Zboril, Radek $u Department of Physical Chemistry, Regional Centre of Advanced Technologies and Materials, Palacky University, Slechtitelu 11, 78371 Olomouc, Czech Republic.
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$a Vianello, Fabio $u Department of Comparative Biomedicine and Food Science, Agripolis Campus, University of Padua, viale dell'Università 16, 35020 Legnaro, Italy. Electronic address: fabio.vianello@unipd.it.
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