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Microbe-focused glycan array screening platform

A. Geissner, A. Reinhardt, C. Rademacher, T. Johannssen, J. Monteiro, B. Lepenies, M. Thépaut, F. Fieschi, J. Mrázková, M. Wimmerova, F. Schuhmacher, S. Götze, D. Grünstein, X. Guo, HS. Hahm, J. Kandasamy, D. Leonori, CE. Martin, SG....

. 2019 ; 116 (6) : 1958-1967. [pub] 20190122

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19027882
E-zdroje Online Plný text

NLK Free Medical Journals od 1915 do Před 6 měsíci
Freely Accessible Science Journals od 1915 do Před 6 měsíci
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Open Access Digital Library od 1915-01-15
Open Access Digital Library od 1915-01-01

Odkazy

PubMed 30670663
DOI 10.1073/pnas.1800853116
Knihovny.cz E-zdroje

Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe-focused glycan microarray platform based on oligosaccharides obtained by chemical synthesis. Glycans were generated by combining different carbohydrate synthesis approaches including automated glycan assembly, solution-phase synthesis, and chemoenzymatic methods. The current library of more than 300 glycans is as diverse as the mammalian glycan array from the Consortium for Functional Glycomics and, due to its microbial focus, highly complementary. This glycan platform is essential for the characterization of various classes of glycan binding proteins. Applications of this glycan array platform are highlighted by the characterization of innate immune receptors and bacterial virulence factors as well as the analysis of human humoral immunity to pathogenic glycans.

Citace poskytuje Crossref.org

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