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Microbe-focused glycan array screening platform
A. Geissner, A. Reinhardt, C. Rademacher, T. Johannssen, J. Monteiro, B. Lepenies, M. Thépaut, F. Fieschi, J. Mrázková, M. Wimmerova, F. Schuhmacher, S. Götze, D. Grünstein, X. Guo, HS. Hahm, J. Kandasamy, D. Leonori, CE. Martin, SG....
Proceedings of the National Academy of Sciences of the United States of America.
2019 ;
116 (6) :
1958-1967.
[pub] 20190122
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc19027882
Online
Full text
NLK
Free Medical Journals
from 1915 to 6 months ago
Freely Accessible Science Journals
from 1915 to 6 months ago
PubMed Central
from 1915 to 6 months ago
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Open Access Digital Library
from 1915-01-15
- MeSH
- Antigens, Bacterial chemistry immunology MeSH
- CHO Cells MeSH
- Cricetulus MeSH
- Species Specificity MeSH
- Glycomics MeSH
- Immune System MeSH
- Lectins MeSH
- Humans MeSH
- Microarray Analysis methods MeSH
- Oligosaccharides MeSH
- Polysaccharides chemistry classification immunology MeSH
- Recombinant Proteins MeSH
- Carrier Proteins chemistry MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Interactions between glycans and glycan binding proteins are essential for numerous processes in all kingdoms of life. Glycan microarrays are an excellent tool to examine protein-glycan interactions. Here, we present a microbe-focused glycan microarray platform based on oligosaccharides obtained by chemical synthesis. Glycans were generated by combining different carbohydrate synthesis approaches including automated glycan assembly, solution-phase synthesis, and chemoenzymatic methods. The current library of more than 300 glycans is as diverse as the mammalian glycan array from the Consortium for Functional Glycomics and, due to its microbial focus, highly complementary. This glycan platform is essential for the characterization of various classes of glycan binding proteins. Applications of this glycan array platform are highlighted by the characterization of innate immune receptors and bacterial virulence factors as well as the analysis of human humoral immunity to pathogenic glycans.
Central European Institute of Technology Masaryk University 625 00 Brno Czech Republic
Institute of Chemistry and Biochemistry Freie Universität Berlin 14195 Berlin Germany
References provided by Crossref.org
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