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Discovery of common and rare genetic risk variants for colorectal cancer
JR. Huyghe, SA. Bien, TA. Harrison et.al.
Language English Country United States
Document type Journal Article, Meta-Analysis
Grant support
R01 CA059045
NCI NIH HHS - United States
R01 CA197350
NCI NIH HHS - United States
R35 CA197735
NCI NIH HHS - United States
R01 CA204279
NCI NIH HHS - United States
P30 CA015704
NCI NIH HHS - United States
K01 DK110267
NIDDK NIH HHS - United States
R01 CA160356
NCI NIH HHS - United States
R01 CA189184
NCI NIH HHS - United States
U01 CA137088
NCI NIH HHS - United States
K23 DK103119
NIDDK NIH HHS - United States
U01 CA164930
NCI NIH HHS - United States
R21 CA191312
NCI NIH HHS - United States
U01 CA206110
NCI NIH HHS - United States
U01 CA185094
NCI NIH HHS - United States
P30 CA014089
NCI NIH HHS - United States
R01 CA081488
NCI NIH HHS - United States
R01 CA201407
NCI NIH HHS - United States
R01 CA207371
NCI NIH HHS - United States
K05 CA152715
NCI NIH HHS - United States
10822
Cancer Research UK - United Kingdom
S10 OD020069
NIH HHS - United States
10119
Cancer Research UK - United Kingdom
P01 CA196569
NCI NIH HHS - United States
10589
Cancer Research UK - United Kingdom
HHSN268201200008I
NHLBI NIH HHS - United States
U01 CA152756
NCI NIH HHS - United States
R01 CA193677
NCI NIH HHS - United States
MR/L01629X/1
Medical Research Council - United Kingdom
P30 CA042014
NCI NIH HHS - United States
U19 CA148107
NCI NIH HHS - United States
10124
Cancer Research UK - United Kingdom
NV15-27580A
MZ0
CEP Register
NV15-27580A
MZ0
CEP Register
Digital library NLK
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ProQuest Central
from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest)
from 2000-01-01 to 1 year ago
Public Health Database (ProQuest)
from 2000-01-01 to 1 year ago
- MeSH
- Genome-Wide Association Study methods MeSH
- Genetic Predisposition to Disease genetics MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide genetics MeSH
- Colorectal Neoplasms genetics MeSH
- Middle Aged MeSH
- Humans MeSH
- Risk Factors MeSH
- RNA, Long Noncoding genetics MeSH
- Aged MeSH
- Signal Transduction genetics MeSH
- Case-Control Studies MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10-8, bringing the number of known independent signals for CRC to ~100. New signals implicate lower-frequency variants, Krüppel-like factors, Hedgehog signaling, Hippo-YAP signaling, long noncoding RNAs and somatic drivers, and support a role for immune function. Heritability analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies enabling rare variant analysis will improve understanding of biology underlying this risk and influence personalized screening strategies and drug development.
Behavioral and Epidemiology Research Group American Cancer Society Atlanta GA USA
Biomedical Informatics Program Stanford University Stanford CA USA
Cancer Epidemiology Unit Nuffield Department of Population Health University of Oxford Oxford UK
Center for Gastrointestinal Biology and Disease University of North Carolina Chapel Hill NC USA
Center for Public Health Genomics University of Virginia Charlottesville VA USA
Centre for Cancer Genetic Epidemiology Department of Oncology University of Cambridge Cambridge UK
CIBER de Epidemiología y Salud Pública University of León León Spain
Clinical Research Division Fred Hutchinson Cancer Research Center Seattle WA USA
Department of Biostatistics University of Washington Seattle WA USA
Department of Cancer Epidemiology H Lee Moffitt Cancer Center and Research Institute Tampa FL USA
Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center Haifa Israel
Department of Computer Science Stanford University Stanford CA USA
Department of Epidemiology German Institute of Human Nutrition Potsdam Rehbrücke Germany
Department of Epidemiology University of Michigan Ann Arbor MI USA
Department of Genetics Stanford University Stanford CA USA
Department of Genome Sciences University of Washington Seattle WA USA
Department of Health Science Research Mayo Clinic Scottsdale AZ USA
Department of Hematology Oncology Chonnam National University Hospital Hwasun South Korea
Department of Internal Medicine University of Utah Salt Lake City UT USA
Department of Medicine 1 University Hospital Dresden Technische Universität Dresden Dresden Germany
Department of Medicine and Epidemiology University of Pittsburgh Medical Center Pittsburgh PA USA
Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA
Department of Medicine University of North Carolina School of Medicine Chapel Hill NC USA
Department of Preventive Medicine Chonnam National University Medical School Gwangju Korea
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland
Department of Radiation Sciences Oncology Unit Umeå University Umeå Sweden
Department of Surgery Chonnam National University Hwasun Hospital and Medical School Hwasun Korea
Division of Cancer Control and Population Sciences National Cancer Institute Bethesda MD USA
Division of Cancer Epidemiology German Cancer Research Center Hamburg Germany
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Epidemiology and Community Health University of Minnesota Minneapolis MN USA
Division of Hematology University of Toronto Toronto Ontario Canada
Division of Human Nutrition and Health Wageningen University and Research Wageningen The Netherlands
Division of Oncology Department of Medicine Stanford University Stanford CA USA
Division of Research Kaiser Permanente Medical Care Program Oakland CA USA
Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Milan Italy
Genomics Shared Resource Fred Hutchinson Cancer Research Center Seattle WA USA
Institute for Health Research Kaiser Permanente Colorado Denver CO USA
Institute of Cancer Research Department of Medicine 1 Medical University of Vienna Vienna Austria
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Epidemiology PopGen Biobank Christian Albrechts University Kiel Kiel Germany
International Agency for Research on Cancer World Health Organization Lyon France
Leeds Institute of Medical Research at St James's University of Leeds Leeds UK
Memorial University of Newfoundland Discipline of Genetics St John's Newfoundland Canada
National Institute for Public Health and the Environment Bilthoven The Netherlands
Office of Public Health Studies University of Hawaii Manoa Honolulu HI USA
Oncology Unit Hillel Yaffe Medical Center Hadera Israel
Ontario Institute for Cancer Research Toronto Ontario Canada
Public Health Sciences Division Fred Hutchinson Cancer Research Center Seattle WA USA
Saarland Cancer Registry Saarbrücken Germany
School of Medicine University of Dundee Dundee Scotland UK
School of Public Health Imperial College London London UK
Service de Génétique Médicale Centre Hospitalier Universitaire Nantes Nantes France
SWOG Statistical Center Fred Hutchinson Cancer Research Center Seattle WA USA
The Clinical Epidemiology Unit Memorial University Medical School Newfoundland Canada
Translational Genomics Research Institute An Affiliate of City of Hope Phoenix AZ USA
University of Hawaii Cancer Research Center Honolulu HI USA
University of Michigan Comprehensive Cancer Center Ann Arbor MI USA
USC Norris Comprehensive Cancer Center University of Southern California Los Angeles CA USA
References provided by Crossref.org
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- 700 1_
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- 700 1_
- $a Lieb, Wolfgang $u Institute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany.
- 700 1_
- $a Lin, Yi $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Lindblom, Annika $u Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Lindor, Noralane M $u Department of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
- 700 1_
- $a Ling, Hua $u Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Louie, Tin L $u Department of Biostatistics, University of Washington, Seattle, WA, USA.
- 700 1_
- $a Männistö, Satu $u Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
- 700 1_
- $a Markowitz, Sanford D $u Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, OH, USA.
- 700 1_
- $a Martín, Vicente $u CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Biomedicine Institute (IBIOMED), University of León, León, Spain.
- 700 1_
- $a Masala, Giovanna $u Cancer Risk Factors and Life-Style Epidemiology Unit, Institute of Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.
- 700 1_
- $a McNeil, Caroline E $u USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a Melas, Marilena $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a Milne, Roger L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
- 700 1_
- $a Moreno, Lorena $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Murphy, Neil $u Nutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
- 700 1_
- $a Myte, Robin $u Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
- 700 1_
- $a Naccarati, Alessio $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic. Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
- 700 1_
- $a Newcomb, Polly A $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Department of Epidemiology, University of Washington, Seattle, WA, USA.
- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
- 700 1_
- $a Ogino, Shuji $u Broad Institute of Harvard and MIT, Cambridge, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
- 700 1_
- $a Onland-Moret, N Charlotte $u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
- 700 1_
- $a Pardini, Barbara $u Italian Institute for Genomic Medicine (IIGM), Turin, Italy. Department of Medical Sciences, University of Turin, Turin, Italy.
- 700 1_
- $a Parfrey, Patrick S $u The Clinical Epidemiology Unit, Memorial University Medical School, Newfoundland, Canada.
- 700 1_
- $a Pearlman, Rachel $u Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
- 700 1_
- $a Perduca, Vittorio $u Laboratoire de Mathématiques Appliquées MAP5 (UMR CNRS 8145), Université Paris Descartes, Paris, France. CESP (Inserm U1018), Facultés de Medicine Université Paris-Sud, UVSQ, Université Paris-Saclay, Gustave Roussy, Villejuif, France.
- 700 1_
- $a Pharoah, Paul D P $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Pinchev, Mila $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
- 700 1_
- $a Platz, Elizabeth A $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Prentice, Ross L $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Pugh, Elizabeth $u Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Raskin, Leon $u Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
- 700 1_
- $a Rennert, Gad $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel. Clalit National Cancer Control Center, Haifa, Israel. Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
- 700 1_
- $a Rennert, Hedy S $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel. Clalit National Cancer Control Center, Haifa, Israel. Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
- 700 1_
- $a Riboli, Elio $u School of Public Health, Imperial College London, London, UK.
- 700 1_
- $a Rodríguez-Barranco, Miguel $u CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada, Universidad de Granada, Granada, Spain.
- 700 1_
- $a Romm, Jane $u Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Sakoda, Lori C $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
- 700 1_
- $a Schafmayer, Clemens $u Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
- 700 1_
- $a Schoen, Robert E $u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
- 700 1_
- $a Seminara, Daniela $u Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
- 700 1_
- $a Shah, Mitul $u Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Shelford, Tameka $u Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Shin, Min-Ho $u Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
- 700 1_
- $a Shulman, Katerina $u Oncology Unit, Hillel Yaffe Medical Center, Hadera, Israel.
- 700 1_
- $a Sieri, Sabina $u Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
- 700 1_
- $a Slattery, Martha L $u Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
- 700 1_
- $a Southey, Melissa C $u Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
- 700 1_
- $a Stadler, Zsofia K $u Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- 700 1_
- $a Stegmaier, Christa $u Saarland Cancer Registry, Saarbrücken, Germany.
- 700 1_
- $a Su, Yu-Ru $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Tangen, Catherine M $u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Thibodeau, Stephen N $u Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Thomas, Duncan C $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a Thomas, Sushma S $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Toland, Amanda E $u Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
- 700 1_
- $a Trichopoulou, Antonia $u Hellenic Health Foundation, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
- 700 1_
- $a Ulrich, Cornelia M $u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
- 700 1_
- $a Van Den Berg, David J $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a van Duijnhoven, Franzel J B $u Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
- 700 1_
- $a Van Guelpen, Bethany $u Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
- 700 1_
- $a van Kranen, Henk $u National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
- 700 1_
- $a Vijai, Joseph $u Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
- 700 1_
- $a Visvanathan, Kala $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Vodicka, Pavel $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic. Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Vodickova, Ludmila $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic. Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Vymetalkova, Veronika $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic. Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic. Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Weigl, Korbinian $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. Medical Faculty, University of Heidelberg, Heidelberg, Germany.
- 700 1_
- $a Weinstein, Stephanie J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
- 700 1_
- $a White, Emily $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Win, Aung Ko $u Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Wolf, C Roland $u School of Medicine, University of Dundee, Dundee, Scotland, UK.
- 700 1_
- $a Wolk, Alicja $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
- 700 1_
- $a Woods, Michael O $u Memorial University of Newfoundland, Discipline of Genetics, St. John's, Newfoundland, Canada.
- 700 1_
- $a Wu, Anna H $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a Zaidi, Syed H $u Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
- 700 1_
- $a Zanke, Brent W $u Division of Hematology, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Zhang, Qing $u Genomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Zheng, Wei $u Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
- 700 1_
- $a Scacheri, Peter C $u Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, OH, USA.
- 700 1_
- $a Potter, John D $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
- 700 1_
- $a Bassik, Michael C $u Department of Genetics, Stanford University, Stanford, CA, USA.
- 700 1_
- $a Kundaje, Anshul $u Department of Computer Science, Stanford University, Stanford, CA, USA. Department of Genetics, Stanford University, Stanford, CA, USA.
- 700 1_
- $a Casey, Graham $u Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
- 700 1_
- $a Moreno, Victor $u Cancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain. Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute-IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
- 700 1_
- $a Abecasis, Goncalo R $u Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
- 700 1_
- $a Nickerson, Deborah A $u Department of Genome Sciences, University of Washington, Seattle, WA, USA.
- 700 1_
- $a Gruber, Stephen B $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
- 700 1_
- $a Hsu, Li $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Department of Biostatistics, University of Washington, Seattle, WA, USA.
- 700 1_
- $a Peters, Ulrike $u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. upeters@fredhutch.org. Department of Epidemiology, University of Washington, Seattle, WA, USA. upeters@fredhutch.org.
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