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Radiolabeling of the antibody IgG M75 for epitope of human carbonic anhydrase IX by 61Cu and 64Cu and its biological testing

A. Čepa, J. Ráliš, L. Marešová, M. Kleinová, D. Seifert, I. Sieglová, V. Král, M. Polášek, M. Paurová, M. Lázníček, O. Lebeda,

. 2019 ; 143 (-) : 87-97. [pub] 20181025

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19028116

Human carbonic anhydrase IX is a membrane enzyme that is significantly expressed in some types of cancer cells, while copper radioisotopes offer wide range of diagnostic, therapeutic and theranostic properties. The work was focused on a new approach to the labelling of antibody IgG M75 for epitope human carbonic anhydrase IX with copper radioisotopes 61Cu and 64Cu and its in vivo testing in mice with inoculated colorectal cancer. Monoclonal antibody IgG M75 for epitope human carbonic anhydrase IX was successfully conjugated with copper-specific chelator "phosphinate" and labelled with 61Cu and 64Cu The obtained molecule has considerable potential as a radioimmuno pharmaceutical suitable for imaging of tumours expressing carbonic anhydrase IX by positron emission tomography (PET).

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$a Radiolabeling of the antibody IgG M75 for epitope of human carbonic anhydrase IX by 61Cu and 64Cu and its biological testing / $c A. Čepa, J. Ráliš, L. Marešová, M. Kleinová, D. Seifert, I. Sieglová, V. Král, M. Polášek, M. Paurová, M. Lázníček, O. Lebeda,
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$a Human carbonic anhydrase IX is a membrane enzyme that is significantly expressed in some types of cancer cells, while copper radioisotopes offer wide range of diagnostic, therapeutic and theranostic properties. The work was focused on a new approach to the labelling of antibody IgG M75 for epitope human carbonic anhydrase IX with copper radioisotopes 61Cu and 64Cu and its in vivo testing in mice with inoculated colorectal cancer. Monoclonal antibody IgG M75 for epitope human carbonic anhydrase IX was successfully conjugated with copper-specific chelator "phosphinate" and labelled with 61Cu and 64Cu The obtained molecule has considerable potential as a radioimmuno pharmaceutical suitable for imaging of tumours expressing carbonic anhydrase IX by positron emission tomography (PET).
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$a Ráliš, Jan $u Department of Radiopharmaceuticals, Nuclear Physics Institute of the CAS, Czech Republic.
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$a Kleinová, Markéta $u ÚJV Řež, a. s., Czech Republic.
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$a Seifert, Daniel $u Department of Radiopharmaceuticals, Nuclear Physics Institute of the CAS, Czech Republic.
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$a Polášek, Miloslav $u Department of Radiopharmaceuticals, Nuclear Physics Institute of the CAS, Czech Republic.
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$a Paurová, Monika $u Department of Inorganic Chemistry, Faculty of Science, Charles University in Prague, Czech Republic.
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$a Lázníček, Milan $u Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic.
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$a Lebeda, Ondřej $u Department of Radiopharmaceuticals, Nuclear Physics Institute of the CAS, Czech Republic. Electronic address: lebeda@ujf.cas.cz.
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