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Isothiocyanate from Broccoli, Sulforaphane, and Its Properties
A. Vanduchova, P. Anzenbacher, E. Anzenbacherova,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, přehledy
PubMed
30372361
DOI
10.1089/jmf.2018.0024
Knihovny.cz E-zdroje
- MeSH
- autistická porucha * farmakoterapie MeSH
- Brassica chemie MeSH
- fytogenní protinádorové látky terapeutické užití MeSH
- glukosinoláty metabolismus MeSH
- imidoestery metabolismus MeSH
- isothiokyanatany * chemie farmakologie terapeutické užití MeSH
- lidé MeSH
- nádory * prevence a kontrola MeSH
- osteoporóza farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane is extensively investigated and is in the interest in medicine for its health benefits. It has been shown that sulforaphane may protect against various types of cancer, may also decrease the risk of cardiovascular disease, and help in autism and osteoporosis. Our review offers a short summary of interesting properties of sulforaphane. Both the in vitro and in vivo methods/models and clinical studies are mentioned.
Citace poskytuje Crossref.org
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- $a Vanduchova, Alena $u 1 Department of Pharmacology, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic . 2 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc , Olomouc, Czech Republic .
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- $a Sulforaphane is an isothiocyanate occurring in stored form as glucoraphanin in cruciferous vegetables such as cabbage, cauliflower, and kale, and at high levels in broccoli especially in broccoli sprouts. Glucoraphanin requires the plant enzyme myrosinase for converting it into sulforaphane. Sulforaphane is metabolized through mercapturic acid pathway, being conjugated with glutathione and undergoes further biotransformation, yielding metabolites. Sulforaphane is extensively investigated and is in the interest in medicine for its health benefits. It has been shown that sulforaphane may protect against various types of cancer, may also decrease the risk of cardiovascular disease, and help in autism and osteoporosis. Our review offers a short summary of interesting properties of sulforaphane. Both the in vitro and in vivo methods/models and clinical studies are mentioned.
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