-
Something wrong with this record ?
Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study
J. Burisch, KH. Katsanos, DK. Christodoulou, L. Barros, F. Magro, N. Pedersen, J. Kjeldsen, Z. Vegh, PL. Lakatos, C. Eriksson, J. Halfvarson, M. Fumery, C. Gower-Rousseau, M. Brinar, S. Cukovic-Cavka, I. Nikulina, E. Belousova, S. Myers, S....
Language English Country England, Great Britain
Document type Journal Article
- MeSH
- Adult MeSH
- Gastrointestinal Agents therapeutic use MeSH
- Hospitalization statistics & numerical data MeSH
- Immunologic Factors therapeutic use MeSH
- Colectomy statistics & numerical data MeSH
- Middle Aged MeSH
- Humans MeSH
- Follow-Up Studies MeSH
- Disease Progression MeSH
- Prospective Studies MeSH
- Colitis, Ulcerative pathology therapy MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Geographicals
- Europe MeSH
Background and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort. Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis. Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8]. Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation.
1st Department of Medicine Semmelweis University Budapest Hungary
American Gastroenterology Center Nicosia Cyprus
Clinic of Gastroenterology University of Medicine 'Victor Babes' Timisoara Romania
Department of Gastroenterology Centro Hospitalar de São João EPE Porto Portugal
Department of Gastroenterology Faculty of Medicine and Health Örebro University Örebro Sweden
Department of Gastroenterology Moscow Regional Research Clinical Institute Moscow Russian Federation
Department of Gastroenterology Nordsjællands Hospital University of Copenhagen Frederikssund Denmark
Department of Gastroenterology University Hospital of Ioannina Ioannina Greece
Department of Medicine Herning Central Hospital Herning Denmark
Division of Gastroenterology Mater Dei Hospital Msida Malta
Division of Gastroenterology Tartu University Hospital University of Tartu Tartu Estonia
Gastroenterology Department Odense University Hospital Odense Denmark
Gastroenterology Department Slagelse Hospital Slagelse Denmark
Gastroenterology Unit Epimad Registry CHU Amiens Sud Amiens University Hospital Amiens France
IBD Clinical and Research Centre ISCARE Prague Czech Republic
IBD Department St Mark's Hospital London UK
IBD Unit Hull and East Yorkshire NHS Trust Hull UK
Medical Department National Hospital of the Faroe Islands Torshavn Faroe Islands
Medical Department Regional Hospital of Viborg Viborg Denmark
U O Gastroenterologia ed Endoscopia digestiva Hospital Morgagni Pierantoni Forlì Italy
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19028169
- 003
- CZ-PrNML
- 005
- 20200310083507.0
- 007
- ta
- 008
- 190813s2019 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/ecco-jcc/jjy154 $2 doi
- 035 __
- $a (PubMed)30289522
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Burisch, Johan $u Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
- 245 10
- $a Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study / $c J. Burisch, KH. Katsanos, DK. Christodoulou, L. Barros, F. Magro, N. Pedersen, J. Kjeldsen, Z. Vegh, PL. Lakatos, C. Eriksson, J. Halfvarson, M. Fumery, C. Gower-Rousseau, M. Brinar, S. Cukovic-Cavka, I. Nikulina, E. Belousova, S. Myers, S. Sebastian, G. Kiudelis, L. Kupcinskas, D. Schwartz, S. Odes, IP. Kaimakliotis, D. Valpiani, R. D'Incà, R. Salupere, S. Chetcuti Zammit, P. Ellul, D. Duricova, M. Bortlik, A. Goldis, HAL. Kievit, A. Toca, S. Turcan, J. Midjord, KR. Nielsen, KW. Andersen, V. Andersen, R. Misra, N. Arebi, P. Oksanen, P. Collin, L. de Castro, V. Hernandez, E. Langholz, P. Munkholm, Epi-IBD Group,
- 520 9_
- $a Background and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort. Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis. Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8]. Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a kolektomie $x statistika a číselné údaje $7 D003082
- 650 _2
- $a ulcerózní kolitida $x patologie $x terapie $7 D003093
- 650 _2
- $a progrese nemoci $7 D018450
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a následné studie $7 D005500
- 650 _2
- $a gastrointestinální látky $x terapeutické užití $7 D005765
- 650 _2
- $a hospitalizace $x statistika a číselné údaje $7 D006760
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunologické faktory $x terapeutické užití $7 D007155
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prospektivní studie $7 D011446
- 651 _2
- $a Evropa $7 D005060
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Katsanos, Konstantinos H $u Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
- 700 1_
- $a Christodoulou, Dimitrios K $u Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
- 700 1_
- $a Barros, Luisa $u Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal.
- 700 1_
- $a Magro, Fernando $u Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal. Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine of Porto University, Porto, Portugal.
- 700 1_
- $a Pedersen, Natalia $u Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark.
- 700 1_
- $a Kjeldsen, Jens $u Gastroenterology Department, Odense University Hospital, Odense, Denmark.
- 700 1_
- $a Vegh, Zsuzsanna $u First Department of Medicine, Semmelweis University, Budapest, Hungary.
- 700 1_
- $a Lakatos, Peter L $u First Department of Medicine, Semmelweis University, Budapest, Hungary. Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada.
- 700 1_
- $a Eriksson, Carl $u Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
- 700 1_
- $a Halfvarson, Jonas, $d 1970- $7 xx0245713 $u Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
- 700 1_
- $a Fumery, Mathurin $u Gastroenterology Unit, Epimad Registry, CHU Amiens Sud, Amiens University Hospital, Amiens, France.
- 700 1_
- $a Gower-Rousseau, Corinne $u Public Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France. Lille Inflammation Research International Center LIRIC, Lille University, Lille, France.
- 700 1_
- $a Brinar, Marko $u Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia. School of Medicine, University of Zagreb, Zagreb, Croatia.
- 700 1_
- $a Cukovic-Cavka, Silvija $u Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia. School of Medicine, University of Zagreb, Zagreb, Croatia.
- 700 1_
- $a Nikulina, Inna $u Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
- 700 1_
- $a Belousova, Elena $u Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
- 700 1_
- $a Myers, Sally $u IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK.
- 700 1_
- $a Sebastian, Shaji $u IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK.
- 700 1_
- $a Kiudelis, Gediminas $u Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
- 700 1_
- $a Kupcinskas, Limas $u Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
- 700 1_
- $a Schwartz, Doron $u Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
- 700 1_
- $a Odes, Selwyn $u Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
- 700 1_
- $a Kaimakliotis, Ioannis P $u American Gastroenterology Center, Nicosia, Cyprus.
- 700 1_
- $a Valpiani, Daniela $u U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy.
- 700 1_
- $a D'Incà, Renata $u Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy.
- 700 1_
- $a Salupere, Riina $u Division of Gastroenterology, Tartu University Hospital, University of Tartu, Tartu, Estonia.
- 700 1_
- $a Chetcuti Zammit, Stefania $u Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
- 700 1_
- $a Ellul, Pierre $u Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
- 700 1_
- $a Duricova, Dana $u IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic.
- 700 1_
- $a Bortlik, Martin $u IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic. Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
- 700 1_
- $a Goldis, Adrian $u Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
- 700 1_
- $a Kievit, Hendrika Adriana Linda $u Department of Medicine, Herning Central Hospital, Herning, Denmark.
- 700 1_
- $a Toca, Alina $u Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
- 700 1_
- $a Turcan, Svetlana $u Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
- 700 1_
- $a Midjord, Jóngerð $u Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
- 700 1_
- $a Nielsen, Kári Rubek $u Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
- 700 1_
- $a Andersen, Karina Winther $u Medical Department, Regional Hospital of Viborg, Viborg, Denmark.
- 700 1_
- $a Andersen, Vibeke $u Medical Department, Regional Hospital of Viborg, Viborg, Denmark. Focused Research Unit for Molecular Diagnostic and Clinical Research [MOK], IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark. Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
- 700 1_
- $a Misra, Ravi $u IBD Department, St Mark's Hospital, London, UK.
- 700 1_
- $a Arebi, Naila $u IBD Department, St Mark's Hospital, London, UK.
- 700 1_
- $a Oksanen, Pia $u Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland. University of Tampere, Tampere, Finland.
- 700 1_
- $a Collin, Pekka $u Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland. University of Tampere, Tampere, Finland.
- 700 1_
- $a de Castro, Luisa $u Department of Gastroenterology. Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain.
- 700 1_
- $a Hernandez, Vicent $u Department of Gastroenterology. Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain.
- 700 1_
- $a Langholz, Ebbe $u Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
- 700 1_
- $a Munkholm, Pia $u Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
- 710 2_
- $a Epi-IBD Group
- 773 0_
- $w MED00166945 $t Journal of Crohn's & colitis $x 1876-4479 $g Roč. 13, č. 2 (2019), s. 198-208
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30289522 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190813 $b ABA008
- 991 __
- $a 20200310083926 $b ABA008
- 999 __
- $a ok $b bmc $g 1433318 $s 1066629
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 13 $c 2 $d 198-208 $e 2019Feb01 $i 1876-4479 $m Journal of Crohn's and colitis $n J Crohns Colitis $x MED00166945
- LZP __
- $a Pubmed-20190813
