• Je něco špatně v tomto záznamu ?

Rolle der NADPH-Oxidasen eukaryotischer Zellen in der Immunabwehr und Signaltransduktion : Übersicht [The defense and signaling role of NADPH oxidases in eukaryotic cells : Review]

M. Breitenbach, M. Rinnerthaler, M. Weber, H. Breitenbach-Koller, T. Karl, P. Cullen, S. Basu, D. Haskova, J. Hasek,

. 2018 ; 168 (11-12) : 286-299. [pub] 20180806

Jazyk angličtina Země Rakousko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19028283

Grantová podpora
R01 GM098629 NIGMS NIH HHS - United States
P26713 Österreichische Forschungsförderungsgesellschaft
CZ 10/2014 Österreichische Austauschdienst

This short review article summarizes what is known clinically and biochemically about the seven human NADPH oxidases. Emphasis is put on the connection between mutations in the catalytic and regulatory subunits of Nox2, the phagocyte defense enzyme, with syndromes like chronic granulomatous disease, as well as a number of chronic inflammatory diseases. These arise paradoxically from a lack of reactive oxygen species production needed as second messengers for immune regulation. Both Nox2 and the six other human NADPH oxidases display signaling functions in addition to the functions of these enzymes in specialized biochemical reactions, for instance, synthesis of the hormone thyroxine. NADPH oxidases are also needed by Saccharomyces cerevisiae cells for the regulation of the actin cytoskeleton in times of stress or developmental changes, such as pseudohyphae formation. The article shows that in certain cancer cells Nox4 is also involved in the re-structuring of the actin cytoskeleton, which is required for cell mobility and therefore for metastasis.

The defense and signaling role of NADPH oxidases in eukaryotic cells : Review

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19028283
003      
CZ-PrNML
005      
20190819083857.0
007      
ta
008      
190813s2018 au f 000 0|eng||
009      
AR
024    7_
$a 10.1007/s10354-018-0640-4 $2 doi
035    __
$a (PubMed)30084091
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a au
100    1_
$a Breitenbach, Michael $u Department of Bioscienes, University of Salzburg, Salzburg, Austria. michael.breitenbach@sbg.ac.at.
245    10
$a Rolle der NADPH-Oxidasen eukaryotischer Zellen in der Immunabwehr und Signaltransduktion : Übersicht / $c M. Breitenbach, M. Rinnerthaler, M. Weber, H. Breitenbach-Koller, T. Karl, P. Cullen, S. Basu, D. Haskova, J. Hasek,
246    31
$a The defense and signaling role of NADPH oxidases in eukaryotic cells : Review.
520    9_
$a This short review article summarizes what is known clinically and biochemically about the seven human NADPH oxidases. Emphasis is put on the connection between mutations in the catalytic and regulatory subunits of Nox2, the phagocyte defense enzyme, with syndromes like chronic granulomatous disease, as well as a number of chronic inflammatory diseases. These arise paradoxically from a lack of reactive oxygen species production needed as second messengers for immune regulation. Both Nox2 and the six other human NADPH oxidases display signaling functions in addition to the functions of these enzymes in specialized biochemical reactions, for instance, synthesis of the hormone thyroxine. NADPH oxidases are also needed by Saccharomyces cerevisiae cells for the regulation of the actin cytoskeleton in times of stress or developmental changes, such as pseudohyphae formation. The article shows that in certain cancer cells Nox4 is also involved in the re-structuring of the actin cytoskeleton, which is required for cell mobility and therefore for metastasis.
650    12
$a eukaryotické buňky $7 D005057
650    _2
$a lidé $7 D006801
650    _2
$a NADPH-oxidasa 2 $7 D000074662
650    _2
$a NADPH-oxidasa 4 $7 D000074663
650    12
$a NADPH-oxidasy $x fyziologie $7 D019255
650    _2
$a reaktivní formy kyslíku $7 D017382
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Rinnerthaler, Mark $u Department of Bioscienes, University of Salzburg, Salzburg, Austria.
700    1_
$a Weber, Manuela $u Department of Bioscienes, University of Salzburg, Salzburg, Austria.
700    1_
$a Breitenbach-Koller, Hannelore $u Department of Bioscienes, University of Salzburg, Salzburg, Austria.
700    1_
$a Karl, Thomas $u Department of Bioscienes, University of Salzburg, Salzburg, Austria.
700    1_
$a Cullen, Paul $u Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, USA.
700    1_
$a Basu, Sukaniya $u Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, USA.
700    1_
$a Haskova, Dana $u Laboratory of Cell Reproduction, Institute of Microbiology of AS CR, v.v.i., Prague, Czech Republic.
700    1_
$a Hasek, Jiri $u Laboratory of Cell Reproduction, Institute of Microbiology of AS CR, v.v.i., Prague, Czech Republic.
773    0_
$w MED00010763 $t Wiener medizinische Wochenschrift (1946) $x 1563-258X $g Roč. 168, č. 11-12 (2018), s. 286-299
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30084091 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190813 $b ABA008
991    __
$a 20190819084131 $b ABA008
999    __
$a ok $b bmc $g 1433432 $s 1066743
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 168 $c 11-12 $d 286-299 $e 20180806 $i 1563-258X $m Wiener medizinische Wochenschrift (1946) $n Wien Med Wochenschr $x MED00010763
GRA    __
$a R01 GM098629 $p NIGMS NIH HHS $2 United States
GRA    __
$a P26713 $p Österreichische Forschungsförderungsgesellschaft
GRA    __
$a CZ 10/2014 $p Österreichische Austauschdienst
LZP    __
$a Pubmed-20190813

Najít záznam

Citační ukazatele

Možnosti archivace