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Effect of Water-Soluble Echinochrome Analog on Arrhythmia Severity in Experimental Model of Acute Myocardial Ischemia
OG. Bernikova, KA. Sedova, SN. Kharin, YE. Azarov,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 1997-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-02-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 1997-01-01 do Před 1 rokem
- MeSH
- antiarytmika izolace a purifikace farmakologie MeSH
- elektrokardiografie MeSH
- ischemická choroba srdeční farmakoterapie patofyziologie MeSH
- ježovky chemie MeSH
- kočky MeSH
- koronární okluze chirurgie MeSH
- modely nemocí na zvířatech MeSH
- myokard patologie MeSH
- naftochinony izolace a purifikace farmakologie MeSH
- neúspěšná terapie MeSH
- převodní systém srdeční účinky léků patofyziologie MeSH
- rozpustnost MeSH
- srdeční arytmie farmakoterapie patofyziologie MeSH
- stupeň závažnosti nemoci MeSH
- voda chemie MeSH
- zvířata MeSH
- Check Tag
- kočky MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.
Citace poskytuje Crossref.org
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- $a The effects of therapeutic or preventive-therapeutic administration of water-soluble echinochrome analog U-441 on arrhythmia severity assessed by a set of myocardial spatio-temporal depolarization and repolarization parameters were examined on the model of acute myocardial ischemia in cats. Coronary occlusion increased activation time and decreased repolarization time in the ischemic zone; in addition, it increased both global and borderline (local) dispersions of repolarization. The linear regression model showed that only activation time values measured at the initial state and at termination of occlusion were associated with total arrhythmia score during ischemia (regression coefficient β=0.338, 95%CI=0.074-0.602, p=0.015 and β=0.720, 95%CI=0.323-1.117, p=0.001, respectively). The study revealed no association between administration of echinochrome analog U-441 and arrhythmia severity.
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