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Fibrin Clot Architecture in Acute Ischemic Stroke Treated With Mechanical Thrombectomy With Stent-Retrievers - Cohort Study
D. Krajíčková, A. Krajina, I. Šteiner, O. Vyšata, R. Herzig, M. Lojík, V. Chovanec, J. Raupach, O. Renc, J. Waishaupt, E. Vítková, P. Dulíček, P. Čabelková, M. Vališ,
Jazyk angličtina Země Japonsko
Typ dokumentu časopisecké články, pozorovací studie, práce podpořená grantem
NLK
Free Medical Journals
od 2002
J-STAGE (Japan Science & Technology Information Aggregator, Electronic) - English
od 2002
J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - English
od 2002
Open Access Digital Library
od 2002-01-01
PubMed
29176266
DOI
10.1253/circj.cj-17-0375
Knihovny.cz E-zdroje
- MeSH
- cévní mozková příhoda patologie terapie MeSH
- dospělí MeSH
- fibrin ultrastruktura MeSH
- ischemie mozku MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mechanická trombolýza MeSH
- mladý dospělý MeSH
- počet trombocytů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- stenty MeSH
- trombóza patologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
BACKGROUND: The composition of intra-arterial clots might influence the efficacy of mechanical thrombectomy (MT) in ischemic stroke (IS) due to the acute occlusions within large cerebral arteries. The aims were to assess the factors associated with blood clot structure and the impact of thromboembolus structure on MT using stent-retrievers in patients with acute large artery IS in the anterior circulation.Methods and Results:In an observational cohort study, we studied the components of intra-arterial clots retrieved from large cerebral arteries in 80 patients with acute IS treated with MT with or without i.v. thrombolysis (IVT). Histology of the clots was carried out without knowledge of the clinical findings, including the treatment methods. The components of the clots, their age, origin and semi-quantitative graded changes in the architecture of the fibrin components (e.g., "thinning") were compared via neuro-interventional, clinical and laboratory data. The most prominent changes in the architecture of the fibrin components in the thromboemboli were associated with IVT (applied in 44 patients; OR, 3.50; 95% CI: 1.21-10.10, P=0.02) and platelet count (OR, 2.94; 95% CI: 1.06-8.12, P=0.04). CONCLUSIONS: In patients with large artery IS treated with the MT using stent-retrievers, bridging therapy with IVT preceding MT and higher platelet count were associated with significant changes of the histological structure of blood clots.
Citace poskytuje Crossref.org
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