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Hypersensitivity to material and environmental burden as a possible cause of late complications of cardiac implantable electronic devices

J. Manoušek, I. Andršová, V. Stejskal, J. Vlašínová, M. Sepši, J. Kuta, J. Klánová, M. Mazík, J. Jarkovský, L. Šnajdrová, K. Benešová, T. Novotný, A. Zadáková, J. Špinar,

. 2018 ; 20 (9) : e140-e147. [pub] 20180901

Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19028726

Aims: To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden. Methods and results: The cohort consisted of 20 men and 4 women (mean age: 62.3 ± 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 ± 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008). Conclusion: Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.

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$a Aims: To evaluate whether patients with late complications of pacemakers or implantable cardioverter-defibrillators have hypersensitivity reactions to some of the materials used in generators or in electrodes, or to environmental metal burden. Methods and results: The cohort consisted of 20 men and 4 women (mean age: 62.3 ± 17.2 years) who had a history of late complications of implanted devices. The control group involved 25 men and 8 women (mean age: 64.6 ± 14.0 years) who had comparable devices, but no history of late complications. Lymphocyte transformation test was used to evaluate hypersensitivity to eight metal pollutants (antimony, manganese, mercury, molybdenum, nickel, platinum, tin, and titanium) selected by results of questionnaires on environmental burden, and by material analysis of generators and electrode surfaces. Exposures to metal pollutants were approximately the same in patients and in controls. Titanium alloy used in generators contained at least 99.32% of titanium and trace levels of other metals; higher levels of tin and platinum were detected in electrode surfaces. Hypersensitivity reactions to mercury and tin were significantly more frequent in patients than in controls (patients and controls: mercury: 68.2 and 31.1%, respectively; P = 0.022; tin: 25.0 and 3.2%, respectively; P = 0.035). In contrast, hypersensitivity to manganese was significantly more frequent in controls than in patients (patients and controls: 13.6 and 50.0%, respectively; P = 0.008). Conclusion: Our findings suggest a possible relation between hypersensitivity to metals used in implantable devices or to environmental metal burden and the occurrence of their late complications.
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$a Andršová, Irena $u Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic.
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$a Stejskal, Vera $u Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, Stockholm, Sweden. Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic.
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$a Vlašínová, Jitka $u Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic.
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$a Sepši, Milan $u Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic. Faculty of Medicine, Department of Internal Medicine and Cardiology, Masaryk University, Kamenice 753/5, Brno, Czech Republic.
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$a Klánová, Jana $u Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic.
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$a Mazík, Michal $u Methodical Centre for Conservation, Technical Museum in Brno, Purkynova 105, Brno, Czech Republic.
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$a Jarkovský, Jirí $u Faculty of Medicine, Department of Internal Medicine and Cardiology, Masaryk University, Kamenice 753/5, Brno, Czech Republic. Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Kamenice 126/3, Brno, Czech Republic.
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$a Benešová, Klára $u Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Kamenice 126/3, Brno, Czech Republic.
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$a Novotný, Tomáš $u Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic. Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic.
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$a Zadáková, Andrea $u Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic.
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$a Špinar, Jindrich $u Department of Internal Medicine and Cardiology, University Hospital Brno, Jihlavská 20, Brno, Czech Republic. Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Kamenice 753/5, pavillion A29, Brno, Czech Republic.
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