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Dual tracer 99mTc-pertechnetate/99mTc-MIBI dual-time-point SPECT/CT parathyroid gland assessment regarding to parathyroid gland size and biochemical parameters - two years single imaging centre experience
E. Krčálová, J. Horáček, E. Nováková, M. Cvejn, D. Lazaráková, R. Mikulecký, J. Máslo, J. Čepková, J. Tilšer, J. Doležal
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Grantová podpora
PROGRES Q40-14
Univerzita Karlova v Praze
Digitální knihovna NLK
Zdroj
NLK
Directory of Open Access Journals
od 1997
Free Medical Journals
od 1997
Open Access Digital Library
od 1997-01-01
Medline Complete (EBSCOhost)
od 2012-06-01
ROAD: Directory of Open Access Scholarly Resources
od 1997
- MeSH
- 99mTc-technecistan sodný terapeutické užití MeSH
- časové faktory MeSH
- lidé středního věku MeSH
- lidé MeSH
- paratyreoidea diagnostické zobrazování patologie MeSH
- prediktivní hodnota testů MeSH
- primární hyperparatyreóza diagnostické zobrazování patologie MeSH
- reprodukovatelnost výsledků MeSH
- retrospektivní studie MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- SPECT/CT metody MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
INTRODUCTION: Preoperative parathyroid imaging is inevitable part of focused parathyroid surgery. The aim of our study was assessment of parathyroid scintigraphy diagnostic accuracy regarding to size and metabolic parameters of hyperfunctioning parathyroid tissue. MATERIAL AND METHODS: Parathyroid scintigraphy for suspected primary hyperparathyroidism was performed in 95 patients during years 2015 and 2016. Of them, 75 patients with known clinical outcome (40 underwent surgery, 35 had documented laboratory follow-up) were further retrospectively evaluated. The performance of dual tracer 99mTc-pertechnetate and 99mTc-MIBI subtraction and dual-time-point 99mTc-MIBI imaging with SPECT/CT was analysed. Serum parathyroid hormone (PTH), calcaemia, ionized calcaemia and phosphataemia and ultrasound detected adenoma volume and largest diameter in false negative and true positive findings were compared using Mann-Whitney test. RESULTS: Sensitivity and specificity of parathyroid scintigraphy was 74.5% and 95.8%, respectively. NPV was 63.8% and PPV 97.4%. Hyperfunctioning parathyroid tissue detectability was almost significantly associated with hypophosphataemia and PTH levels. CONCLUSION: Parathyroid scintigraphy provides high sensitivity and superior specificity in parathyroid adenoma location, nevertheless the diagnostic accuracy tends to decline in smaller adenomas and in less metabolically active parathyroid tissue causing only subtle biochemical changes. 18F-Fluorocholine PET/CT or 3D SPECT/CT subtraction should be a reasonable option for those cases.
Náchod Hospital Internal Medicine Department Czech Republic
Náchod Hospital Osteology Outpatient Clinic Czech Republic
Nuclear Medicine Department University Hospital Hradec Králové Czech Republic
Pardubice Hospital Internal Medicine Department Czech Republic
Private Endocrinology Outpatient Clinic Náchod Czech Republic
Citace poskytuje Crossref.org
Literatura
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