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Pharmacokinetics of K117 and K127, two novel antidote candidates to treat Tabun poisoning

K. Tekes, G. Karvaly, S. Nurulain, K. Kuca, K. Musilek, E. Adeghate, YS. Jung, H. Kalász,

. 2019 ; 310 (-) : 108737. [pub] 20190704

Jazyk angličtina Země Irsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19034461

AIMS: K117 and K127 are bis-pyridinium aldoximes but K117 is a bis-pyridinium bis-aldoxime while K127 has only one single aldoxime in addition to its amide substituent. Is there any difference in pharmacokinetics in these compounds that otherwise have the same chemical structure? Both K117 and K127 are developed as antidotes in acetylcholinesterase and butyrylcholinesterase poisoning in terrorist attacks or intoxication with other organophosphorous compounds. Their distributions have been scouted in the bodies of rats. MAIN METHODS: White male Wistar rats were intramuscularly injected. The animals were sacrificed, tissue samples were homogenized, and either K117 or K127 concentrations were determined using reversed-phase high-performance liquid chromatography. KEY FINDINGS: Both K117 and K127 were present in all tissues that were analyzed including blood (serum), the brains, cerebrospinal fluid, the eyes, livers, kidneys, lungs and testes. Their pharmacokinetics and body distributions are similar. SIGNIFICANCE: Either K117 or K127 meets the essential requirements for antidotes. Dose dependence and kinetics of their distribution were compared to that of other pyridinium aldoximes.

Citace poskytuje Crossref.org

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$a AIMS: K117 and K127 are bis-pyridinium aldoximes but K117 is a bis-pyridinium bis-aldoxime while K127 has only one single aldoxime in addition to its amide substituent. Is there any difference in pharmacokinetics in these compounds that otherwise have the same chemical structure? Both K117 and K127 are developed as antidotes in acetylcholinesterase and butyrylcholinesterase poisoning in terrorist attacks or intoxication with other organophosphorous compounds. Their distributions have been scouted in the bodies of rats. MAIN METHODS: White male Wistar rats were intramuscularly injected. The animals were sacrificed, tissue samples were homogenized, and either K117 or K127 concentrations were determined using reversed-phase high-performance liquid chromatography. KEY FINDINGS: Both K117 and K127 were present in all tissues that were analyzed including blood (serum), the brains, cerebrospinal fluid, the eyes, livers, kidneys, lungs and testes. Their pharmacokinetics and body distributions are similar. SIGNIFICANCE: Either K117 or K127 meets the essential requirements for antidotes. Dose dependence and kinetics of their distribution were compared to that of other pyridinium aldoximes.
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$a Karvaly, G $u Department of Laboratory Medicine, Semmelweis University, H-1089, Budapest, Nagyvárad tér 4, Hungary. Electronic address: karvaly.gellert_balazs@med.semmelweis-univ.hu.
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$a Nurulain, S $u Comsats, Islamabad, Pakistan. Electronic address: syed.nurulain@comsats.edu.pk.
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$a Kuca, K $u Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic.
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$a Musilek, K $u Department of Chemistry, University of Hradec Kralove, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic. Electronic address: kamil.musilek@uhk.cz.
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$a Adeghate, E $u Department of Anatomy, United Arab Emirates University, Al Ain, United Arab Emirates. Electronic address: eadeghate@uaeu.ac.ae.
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$a Jung, Y-S $u Medicinal Science Division, Korea Research Institute of Chemical Technology, Daejeon, Republic of Korea. Electronic address: ysjung@krict.re.kr.
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$a Kalász, H $u Department of Pharmacology and Pharmacotherapy, Semmelweis University, H-1089, Budapest, Nagyvárad tér 4, Hungary. Electronic address: drkalasz@gmail.com.
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