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Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro

P. Stastny, R. Sedlacek, T. Suchy, V. Lukasova, M. Rampichova, M. Trunec,

. 2019 ; 100 (-) : 544-553. [pub] 20190309

Language English Country Netherlands

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19034660

Grant support
NV17-31276A MZ0 CEP Register

The structure degradation and strength changes of calcium phosphate scaffolds after long-term exposure to an acidic environment simulating the osteoclastic activity were determined and compared. Sintered calcium phosphate scaffolds with different phase structures were prepared with a similar cellular pore structure and an open porosity of over 80%. Due to microstructural features the biphasic calcium phosphate (BCP) scaffolds had a higher compressive strength of 1.7 MPa compared with the hydroxyapatite (HA) and β-tricalcium phosphate (TCP) scaffolds, which exhibited a similar strength of 1.2 MPa. After exposure to an acidic buffer solution of pH = 5.5, the strength of the HA scaffolds did not change over 14 days. On the other hand, the strength of the TCP scaffolds decreased steeply in the first 2 days and reached a negligible value of 0.09 MPa after 14 days. The strength of the BCP scaffolds showed a steady decrease with a reasonable value of 0.5 MPa after 14 days. The mass loss, phase composition and microstructural changes of the scaffolds during degradation in the acidic environment were investigated and a mechanism of scaffold degradation was proposed. The BCP scaffold showed the best cell response in the in vitro tests. The BCP scaffold structure with the highly soluble phase (α-TCP) embedded in a less soluble matrix (β-TCP/HA) exhibited a controllable degradation with a suitable strength stability and with beneficial biological behavior it represented the preferred calcium phosphate structure for a resorbable bone scaffold.

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$a The structure degradation and strength changes of calcium phosphate scaffolds after long-term exposure to an acidic environment simulating the osteoclastic activity were determined and compared. Sintered calcium phosphate scaffolds with different phase structures were prepared with a similar cellular pore structure and an open porosity of over 80%. Due to microstructural features the biphasic calcium phosphate (BCP) scaffolds had a higher compressive strength of 1.7 MPa compared with the hydroxyapatite (HA) and β-tricalcium phosphate (TCP) scaffolds, which exhibited a similar strength of 1.2 MPa. After exposure to an acidic buffer solution of pH = 5.5, the strength of the HA scaffolds did not change over 14 days. On the other hand, the strength of the TCP scaffolds decreased steeply in the first 2 days and reached a negligible value of 0.09 MPa after 14 days. The strength of the BCP scaffolds showed a steady decrease with a reasonable value of 0.5 MPa after 14 days. The mass loss, phase composition and microstructural changes of the scaffolds during degradation in the acidic environment were investigated and a mechanism of scaffold degradation was proposed. The BCP scaffold showed the best cell response in the in vitro tests. The BCP scaffold structure with the highly soluble phase (α-TCP) embedded in a less soluble matrix (β-TCP/HA) exhibited a controllable degradation with a suitable strength stability and with beneficial biological behavior it represented the preferred calcium phosphate structure for a resorbable bone scaffold.
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$a Sedlacek, Radek $u Department of Mechanics, Biomechanics and Mechatronics, Czech Technical University in Prague, Technicka 4, 166 07 Prague, Czech Republic.
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$a Suchy, Tomas $u Department of Mechanics, Biomechanics and Mechatronics, Czech Technical University in Prague, Technicka 4, 166 07 Prague, Czech Republic; Institute of Rock Structure and Mechanics, Czech Academy of Sciences, V Holesovickach 41, 182 09 Prague, Czech Republic.
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$a Lukasova, Vera $u Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic; University Center for Energy Efficient Buildings, Czech Technical University in Prague, Trinecka 1024, 273 43 Bustehrad, Czech Republic; Department of Cell Biology, Charles University, Vinicna 5, 128 00 Prague, Czech Republic.
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$a Rampichova, Michala $u Institute of Experimental Medicine, Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.
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$a Trunec, Martin $u CEITEC BUT, Brno University of Technology, Purkynova 123, 612 00 Brno, Czech Republic; Institute of Materials Science and Engineering, Brno University of Technology, Technicka 2, 616 69 Brno, Czech Republic. Electronic address: martin.trunec@ceitec.vutbr.cz.
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