• Je něco špatně v tomto záznamu ?

Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease

H. H. Wang, W. Y. Luo, M. Lin, X. J. Li, G. D. Xiang, S. D Triganti

. 2021 ; 70 (2) : 203-211. [pub] 20210308

Jazyk angličtina Země Česko

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22000836

Asprosin, coiled-coil domain-containing 80(CCDC80) and angiopoietin-like4(ANGPTL4) are newly discovered adipocytokine that affects glucose tolerance, insulin resistance and cardiovascular diseases. The goal of this study was to investigate if a relationship exists among asprosin, CCDC80 and ANGPTL4 and inflammatory bowel disease (IBD). Fifty subjects with newly diagnosed IBD and fifty healthy individuals were enrolled. Patients were treated with standard therapies for 3 months. Plasma asprosin, CCDC80 and ANGPTL4 levels were measured with enzyme-linked immunosorbent assay. High resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia (flow-mediated dilation, FMD) and after sublingual glyceryltrinitrate.Compare with healthy individuals, plasma CCDC80,erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels and homeostasis modelassessment of insulin resistance (HOMA-IR) were significantly higher (p < 0.05, respectively), whereas plasma asprosin,ANGPTL4 levels and FMD were significantly lower inboth UC and CD patients(p <0.05). Plasma CCDC80 levels were significantly higher in patients with CD (p<0.05), while plasma asprosin and ANGPTL4 levels were lower (p<0.05) as compared with those in patients with UC. Standard therapies increased plasma asprosin, ANGPTL4 levels and FMD in both UC and CD (p<0.05),UC and CD patientswhile decreased plasma CCDC80, ESR, CRP levels and HOMA-IR (p<0.05). The changes in HOMA-IR and FMD were correlated with the changes in plasma asprosin, CCDC80 and ANGPTL4 levels over the study period (p<0.05). Plasma asprosin, CCDC80 and ANGPTL4 levels may be applied as a significant marker for early stage of insulin resistance and atherosclerosis in IBD, especially of CD.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc22000836
003      
CZ-PrNML
005      
20220225103449.0
007      
ta
008      
220106s2021 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934547 $2 doi
035    __
$a (PubMed)33676388
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Wang, Hao-Hua $u Department of Endocrinology, Tungwah Hospital of Sun Yat-Sen University, Dongguan, China
245    10
$a Plasma asprosin, CCDC80 and ANGPTL4 levels are associated with metabolic and cardiovascular risk in patients with inflammatory bowel disease / $c H. H. Wang, W. Y. Luo, M. Lin, X. J. Li, G. D. Xiang, S. D Triganti
504    __
$a Literatura
520    9_
$a Asprosin, coiled-coil domain-containing 80(CCDC80) and angiopoietin-like4(ANGPTL4) are newly discovered adipocytokine that affects glucose tolerance, insulin resistance and cardiovascular diseases. The goal of this study was to investigate if a relationship exists among asprosin, CCDC80 and ANGPTL4 and inflammatory bowel disease (IBD). Fifty subjects with newly diagnosed IBD and fifty healthy individuals were enrolled. Patients were treated with standard therapies for 3 months. Plasma asprosin, CCDC80 and ANGPTL4 levels were measured with enzyme-linked immunosorbent assay. High resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia (flow-mediated dilation, FMD) and after sublingual glyceryltrinitrate.Compare with healthy individuals, plasma CCDC80,erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels and homeostasis modelassessment of insulin resistance (HOMA-IR) were significantly higher (p < 0.05, respectively), whereas plasma asprosin,ANGPTL4 levels and FMD were significantly lower inboth UC and CD patients(p <0.05). Plasma CCDC80 levels were significantly higher in patients with CD (p<0.05), while plasma asprosin and ANGPTL4 levels were lower (p<0.05) as compared with those in patients with UC. Standard therapies increased plasma asprosin, ANGPTL4 levels and FMD in both UC and CD (p<0.05),UC and CD patientswhile decreased plasma CCDC80, ESR, CRP levels and HOMA-IR (p<0.05). The changes in HOMA-IR and FMD were correlated with the changes in plasma asprosin, CCDC80 and ANGPTL4 levels over the study period (p<0.05). Plasma asprosin, CCDC80 and ANGPTL4 levels may be applied as a significant marker for early stage of insulin resistance and atherosclerosis in IBD, especially of CD.
650    _2
$a dospělí $7 D000328
650    _7
$a angiopoetinu podobný protein 4 $7 D000075803 $2 czmesh
650    _2
$a ateroskleróza $x diagnostické zobrazování $x etiologie $7 D050197
650    _2
$a biologické markery $x krev $7 D015415
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a ulcerózní kolitida $x krev $x komplikace $x diagnóza $7 D003093
650    _2
$a Crohnova nemoc $x krev $x komplikace $x diagnóza $7 D003424
650    _2
$a extracelulární matrix - proteiny $x krev $7 D016326
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a fibrilin 1 $x krev $7 D000071838
650    _2
$a rizikové faktory kardiovaskulárních chorob $7 D000082742
650    _2
$a lidé $7 D006801
650    12
$a inzulinová rezistence $7 D007333
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a prognóza $7 D011379
650    _2
$a hodnocení rizik $7 D018570
650    _2
$a mladý dospělý $7 D055815
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Luo, Wan-Ying $u Department of Endocrinology, Tungwah Hospital of Sun Yat-Sen University, Dongguan, China
700    1_
$a Lin, Min $u Department of Endocrinology, Tungwah Hospital of Sun Yat-Sen University, Dongguan, China
700    1_
$a Li, Xiao-Jing $u Department of Endocrinology, Tungwah Hospital of Sun Yat-Sen University, Dongguan, China
700    1_
$a Xiang, Guang-Da $u Department of Endocrinology, Wuhan General Hospital of Guangzhou Command, Wuhan, China
700    1_
$a D. Triganti, Silvia $u University of Maryland, Baltimore, USA
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 70, č. 2 (2021), s. 203-211
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33676388 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20220106 $b ABA008
991    __
$a 20220225103441 $b ABA008
999    __
$a ok $b bmc $g 1755667 $s 1151982
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 70 $c 2 $d 203-211 $e 20210308 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20220106

Najít záznam

Citační ukazatele

Možnosti archivace