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CD49b defines functionally mature Treg cells that survey skin and vascular tissues
X. Fan, B. Moltedo, A. Mendoza, AN. Davydov, MB. Faire, L. Mazutis, R. Sharma, D. Pe'er, DM. Chudakov, AY. Rudensky,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
F30 AI122721
NIAID NIH HHS - United States
P30 CA008748
NCI NIH HHS - United States
R37 AI034206
NIAID NIH HHS - United States
T32 GM007739
NIGMS NIH HHS - United States
Howard Hughes Medical Institute - United States
PubMed Central od 1896 do Před 6 měsíci
Europe PubMed Central od 1896 do Před 6 měsíci
Open Access Digital Library od 1896-01-01
Open Access Digital Library od 1896-01-01
Open Access Digital Library od 1996-01-01
Odkazy
PubMed
30355617
DOI
10.1084/jem.20181442
Knihovny.cz E-zdroje
- MeSH
- cévy imunologie MeSH
- imunitní dozor * MeSH
- integrin alfa2 genetika imunologie MeSH
- kůže krevní zásobení cytologie imunologie MeSH
- lymfatické uzliny krevní zásobení cytologie imunologie MeSH
- myši transgenní MeSH
- myši MeSH
- regulační T-lymfocyty cytologie imunologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the α2 integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, and skin-draining lymph nodes, but uncommon in the intestines and in viscera-draining lymph nodes. CD49b+ Treg cells, which display superior functionality revealed by in vitro and in vivo assays, appear to develop after multiple rounds of cell division and TCR-dependent activation. Accordingly, single-cell RNA-seq analysis placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues.
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- $a Regulatory T (Treg) cells prevent autoimmunity by limiting immune responses and inflammation in the secondary lymphoid organs and nonlymphoid tissues. While unique subsets of Treg cells have been described in some nonlymphoid tissues, their relationship to Treg cells in secondary lymphoid organs and circulation remains unclear. Furthermore, it is possible that Treg cells from similar tissue types share largely similar properties. We have identified a short-lived effector Treg cell subset that expresses the α2 integrin, CD49b, and exhibits a unique tissue distribution, being abundant in peripheral blood, vasculature, skin, and skin-draining lymph nodes, but uncommon in the intestines and in viscera-draining lymph nodes. CD49b+ Treg cells, which display superior functionality revealed by in vitro and in vivo assays, appear to develop after multiple rounds of cell division and TCR-dependent activation. Accordingly, single-cell RNA-seq analysis placed these cells at the apex of the Treg developmental trajectory. These results shed light on the identity and development of a functionally potent subset of mature effector Treg cells that recirculate through and survey peripheral tissues.
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- $a Davydov, Alexey N $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
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- $a Mazutis, Linas $u Single Cell Research Initiative, Memorial Sloan Kettering Cancer Center, New York, NY. Program for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY.
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- $a Sharma, Roshan $u Program for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY. Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY.
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- $a Pe'er, Dana $u Single Cell Research Initiative, Memorial Sloan Kettering Cancer Center, New York, NY. Program for Computational and Systems Biology, Memorial Sloan Kettering Cancer Center, New York, NY.
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- $a Chudakov, Dmitriy M $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Privolzhsky Research Medical University, Nizhny Novgorod, Russia. Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
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- $a Rudensky, Alexander Y $u Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center, New York, NY rudenska@mskcc.org.
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