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The role of the hippocampus in object discrimination based on visual features
D. Levcik, T. Nekovarova, E. Antosova, A. Stuchlik, D. Klement,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- GABA-A Receptor Agonists pharmacology MeSH
- Behavior, Animal drug effects physiology MeSH
- Discrimination Learning drug effects physiology MeSH
- Generalization, Psychological drug effects physiology MeSH
- Hippocampus drug effects physiology MeSH
- Rats MeSH
- Muscimol pharmacology MeSH
- Conditioning, Operant drug effects physiology MeSH
- Rats, Long-Evans MeSH
- Pattern Recognition, Visual drug effects physiology MeSH
- Form Perception drug effects physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
The role of rodent hippocampus has been intensively studied in different cognitive tasks. However, its role in discrimination of objects remains controversial due to conflicting findings. We tested whether the number and type of features available for the identification of objects might affect the strategy (hippocampal-independent vs. hippocampal-dependent) that rats adopt to solve object discrimination tasks. We trained rats to discriminate 2D visual objects presented on a computer screen. The objects were defined either by their shape only or by multiple-features (a combination of filling pattern and brightness in addition to the shape). Our data showed that objects displayed as simple geometric shapes are not discriminated by trained rats after their hippocampi had been bilaterally inactivated by the GABAA-agonist muscimol. On the other hand, objects containing a specific combination of non-geometric features in addition to the shape are discriminated even without the hippocampus. Our results suggest that the involvement of the hippocampus in visual object discrimination depends on the abundance of object's features.
References provided by Crossref.org
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- $a Levcik, David $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic; Department of Pharmacology, Federal University of Parana, Av. Cel. Francisco Heraclito dos Santos 100, 81531-980 Curitiba, PR, Brazil. Electronic address: david.levcik@centrum.cz.
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- $a The role of the hippocampus in object discrimination based on visual features / $c D. Levcik, T. Nekovarova, E. Antosova, A. Stuchlik, D. Klement,
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- $a The role of rodent hippocampus has been intensively studied in different cognitive tasks. However, its role in discrimination of objects remains controversial due to conflicting findings. We tested whether the number and type of features available for the identification of objects might affect the strategy (hippocampal-independent vs. hippocampal-dependent) that rats adopt to solve object discrimination tasks. We trained rats to discriminate 2D visual objects presented on a computer screen. The objects were defined either by their shape only or by multiple-features (a combination of filling pattern and brightness in addition to the shape). Our data showed that objects displayed as simple geometric shapes are not discriminated by trained rats after their hippocampi had been bilaterally inactivated by the GABAA-agonist muscimol. On the other hand, objects containing a specific combination of non-geometric features in addition to the shape are discriminated even without the hippocampus. Our results suggest that the involvement of the hippocampus in visual object discrimination depends on the abundance of object's features.
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- $a Nekovarova, Tereza $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic; Department of Applied Neurosciences and Brain Imaging, National Institute of Mental Health, Topolova 748, 250 67 Klecany, Czech Republic; Department of Zoology, Faculty of Natural Science, Charles University in Prague, Vinicna 7, 128 00 Prague 2, Czech Republic; Department of Normal, Pathological and Clinical Physiology, 3rd Faculty of Medicine, Charles University, Ke Karlovu 6, 12000 Prague 2, Czech Republic.
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- $a Antosova, Eliska $u Department of Neurophysiology of Memory, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic; Department of Applied Neurosciences and Brain Imaging, National Institute of Mental Health, Topolova 748, 250 67 Klecany, Czech Republic.
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