-
Je něco špatně v tomto záznamu ?
Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data
P Baliakas, M Iskas, A Gardiner, Z Davis, K Plevova, F Nguyen-Khac, J Malcikova, A Anagnostopoulos, S Glide, S Mould, K Stepanovska, M Brejcha, C Belessi, F Davi, S Pospisilova, A Athanasiadou, K Stamatopoulos, D Oscier
Jazyk angličtina Země Spojené státy americké
Grantová podpora
NT13493
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Zdroj
NLK
Free Medical Journals
od 1998 do Před 1 rokem
Wiley Free Content
od 1996 do Před 1 rokem
PubMed
24166834
DOI
10.1002/ajh.23618
Knihovny.cz E-zdroje
- MeSH
- body zlomu chromozomu MeSH
- buněčné kultury metody MeSH
- chromozomální aberace MeSH
- chromozomální delece MeSH
- chronická lymfatická leukemie * genetika patologie MeSH
- hybridizace in situ fluorescenční MeSH
- interfáze MeSH
- Kaplanův-Meierův odhad MeSH
- karyotypizace metody MeSH
- lidé MeSH
- lidské chromozomy genetika ultrastruktura MeSH
- nádorové buňky kultivované MeSH
- přestavba genů pro těžké řetězce B-lymfocytů MeSH
- proporcionální rizikové modely MeSH
- translokace genetická * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry >= 1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (>= 3 aberrations) was detected in 157 cases and significantly (P < 0.005) associated with unmutated IGHV genes and aberrations of chromosome 17p. Furthermore, it was identified as an independent prognostic factor for shorter time-to-first-treatment. CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival. On this evidence, we propose that all CTRAs in CLL are not equivalent but rather develop by different processes and are associated with distinct clonal behavior.
Baliakas Panagiotis Hematology Department and HCT Unit G Papanicolaou Hospital Thessaloniki Greece
Department of Immunology Genetics and Pathology Uppsala University Uppsala Sweden
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19036349
- 003
- CZ-PrNML
- 005
- 20191010084746.0
- 007
- ta
- 008
- 191010s2014 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1002/ajh.23618 $2 doi
- 035 __
- $a (PubMed)24166834
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Baliakas P $u Baliakas, Panagiotis. Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
- 245 10
- $a Chromosomal translocations and karyotype complexity in chronic lymphocytic leukemia: a systematic reappraisal of classic cytogenetic data / $c P Baliakas, M Iskas, A Gardiner, Z Davis, K Plevova, F Nguyen-Khac, J Malcikova, A Anagnostopoulos, S Glide, S Mould, K Stepanovska, M Brejcha, C Belessi, F Davi, S Pospisilova, A Athanasiadou, K Stamatopoulos, D Oscier
- 520 9_
- $a The significance of chromosomal translocations (CTRAs) and karyotype complexity (KC) in chronic lymphocytic leukemia (CLL) remains uncertain. To gain insight into these issues, we evaluated a series of 1001 CLL cases with reliable classic cytogenetic data obtained within 6 months from diagnosis before any treatment. Overall, 320 cases were found to carry >= 1 CTRAs. The most frequent chromosome breakpoints were 13q, followed by 14q, 18q, 17q, and 17p; notably, CTRAs involving chromosome 13q showed a wide spectrum of translocation partners. KC (>= 3 aberrations) was detected in 157 cases and significantly (P < 0.005) associated with unmutated IGHV genes and aberrations of chromosome 17p. Furthermore, it was identified as an independent prognostic factor for shorter time-to-first-treatment. CTRAs were assigned to two categories (i) CTRAs present in the context of KC, often with involvement of chromosome 17p aberrations, occurring mostly in CLL with unmutated IGHV genes; in such cases, we found that KC rather than the presence of CTRAs per se negatively impacts on survival; (ii) CTRAs in cases without KC, having limited if any impact on survival. On this evidence, we propose that all CTRAs in CLL are not equivalent but rather develop by different processes and are associated with distinct clonal behavior.<ovid:br/><ovid:br/> Copyright © 2013 Wiley Periodicals, Inc.
- 590 __
- $a bohemika - dle Pubmed
- 650 02
- $a buněčné kultury $x metody $7 D018929
- 650 02
- $a chromozomální aberace $7 D002869
- 650 02
- $a body zlomu chromozomu $7 D056905
- 650 02
- $a chromozomální delece $7 D002872
- 650 02
- $a lidské chromozomy $x genetika $x ultrastruktura $7 D002877
- 650 02
- $a ženské pohlaví $7 D005260
- 650 02
- $a přestavba genů pro těžké řetězce B-lymfocytů $7 D015326
- 650 02
- $a lidé $7 D006801
- 650 02
- $a hybridizace in situ fluorescenční $7 D017404
- 650 02
- $a interfáze $7 D007399
- 650 02
- $a Kaplanův-Meierův odhad $7 D053208
- 650 12
- $a Karyotype
- 650 02
- $a karyotypizace $x metody $7 D007621
- 650 12
- $a chronická lymfatická leukemie $x genetika $x patologie $7 D015451
- 650 02
- $a mužské pohlaví $7 D008297
- 650 02
- $a proporcionální rizikové modely $7 D016016
- 650 12
- $a translokace genetická $7 D014178
- 650 02
- $a nádorové buňky kultivované $7 D014407
- 700 1_
- $a Iskas M
- 700 1_
- $a Gardiner A
- 700 1_
- $a Davis Z
- 700 1_
- $a Plevová, Karla $7 xx0158852
- 700 1_
- $a Nguyen-Khac F
- 700 1_
- $a Malčíková, Jitka, $d 1979- $7 mub2011655946
- 700 1_
- $a Anagnostopoulos A
- 700 1_
- $a Glide S
- 700 1_
- $a Mould S
- 700 1_
- $a Stepanovska K
- 700 1_
- $a Brejcha, Martin $7 xx0105595
- 700 1_
- $a Belessi C
- 700 1_
- $a Davi F
- 700 1_
- $a Pospíšilová, Šárka, $d 1969- $7 xx0101843
- 700 1_
- $a Athanasiadou A
- 700 1_
- $a Stamatopoulos K
- 700 1_
- $a Oscier D
- 773 0_
- $t American Journal of Hematology $g Roč. 89, č. 3 (2014), s. 249-255 $p Am J Hematol $x 0361-8609 $w MED00000251
- 773 0_
- $p Am J Hematol $g 89(3):249-55, 2014 Mar
- 910 __
- $a ABA008 $b sig $y 4 $z 0
- 990 __
- $a 20191010085205 $b ABA008
- 991 __
- $a 20191010085205 $b ABA008
- 999 __
- $a ok $b bmc $g 1453436 $s 1074909
- BAS __
- $a 3
- BMC __
- $a 2014 $b 89 $c 3 $d 249-255 $x MED00000251 $i 0361-8609 $m American journal of hematology
- GRA __
- $a NT13493 $p MZ0
- LZP __
- $a NLK 2019/lp
