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Erythropoetiny v terapii z pohledu farmaceutického chemika
[Erythropoetins in therapy from the point of view of a medicinal chemist]
Oldřich Farsa, Peter Zubáč
Status minimální Jazyk čeština Země Česko
Hematopoietic growth factors are cytokines which stimulate growth of hematopoietic pluripotent stem cells and their differentiation and maturation into fully function-al blood cells, either erythrocytes or various types of white blood cells. Erythropoietin is a glycosylated peptide hor-mone which stimulates production of red blood cells. It is used for treatment of anaemia caused by a chronic kidney failure. For therapeutic purposes, it is produced by recom-binant technologies predominantly using modified mam-malian cells. This procedure leads, however, to peptides of the same sequence of 165 amino acids but with different glycosylation patterns. These different mixtures of erythro-poietin glycoforms have been designated with different INN names epoetin alfa – omega. Peginesatid (Omontys®) is a synthetic erythropoietin receptor agonist, the structure of which does not match that of erythropoietin. It is a pegylated covalent dimer of two identical peptide chains. It has been abandoned due to an increased mortality from cardiovascular reasons and due to dangerous allergies.
Erythropoetins in therapy from the point of view of a medicinal chemist
Literatura
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- $a Hematopoietic growth factors are cytokines which stimulate growth of hematopoietic pluripotent stem cells and their differentiation and maturation into fully function-al blood cells, either erythrocytes or various types of white blood cells. Erythropoietin is a glycosylated peptide hor-mone which stimulates production of red blood cells. It is used for treatment of anaemia caused by a chronic kidney failure. For therapeutic purposes, it is produced by recom-binant technologies predominantly using modified mam-malian cells. This procedure leads, however, to peptides of the same sequence of 165 amino acids but with different glycosylation patterns. These different mixtures of erythro-poietin glycoforms have been designated with different INN names epoetin alfa – omega. Peginesatid (Omontys®) is a synthetic erythropoietin receptor agonist, the structure of which does not match that of erythropoietin. It is a pegylated covalent dimer of two identical peptide chains. It has been abandoned due to an increased mortality from cardiovascular reasons and due to dangerous allergies.
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