-
Je něco špatně v tomto záznamu ?
Creutzfeldt-Jakob disease surveillance in Eastern Slovakia from 2004 to 2016
E. Feketeová, D. Jarčušková, A. Janáková, E. Rozprávková, Z. Cifráková, S. Farkašová-Inaccone, K. Rimárová, E. Dorko, Z. Gdovinová
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Digitální knihovna NLK
Zdroj
NLK
Free Medical Journals
od 2004
ProQuest Central
od 2009-03-01 do Před 6 měsíci
Medline Complete (EBSCOhost)
od 2006-03-01 do Před 6 měsíci
Nursing & Allied Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2009-03-01 do Před 6 měsíci
Public Health Database (ProQuest)
od 2009-03-01 do Před 6 měsíci
ROAD: Directory of Open Access Scholarly Resources
od 1993
PubMed
30817871
DOI
10.21101/cejph.a5277
Knihovny.cz E-zdroje
- MeSH
- Creutzfeldtova-Jakobova nemoc diagnóza epidemiologie genetika MeSH
- dospělí MeSH
- encefalopatie bovinní spongioformní * MeSH
- genotyp MeSH
- incidence MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mutace MeSH
- priony genetika MeSH
- rodokmen MeSH
- senioři MeSH
- skot MeSH
- surveillance populace MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři MeSH
- skot MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Slovenská republika MeSH
OBJECTIVES: An extraordinary incidence of genetic Creutzfeldt-Jakob disease (gCJD) appearing in clusters in the Slovak Republic was described in the 1990's. The aim of the study was to analyse data of CJD cases obtained from surveillance in Eastern Slovakia (ES) (2004-2016), the region outside the described geographical clusters. METHODS: The database set in the project was the source for epidemiological and clinical analysis of CJD cases. RESULTS: The incidence of CJD in ES (2004-2016) was 1.7/million person-years (95% CI 1-2.4); the incidence increase in the last five years (2012-2016) was comparable to the whole country. Twenty seven of 29 reported CJD cases were available for analysis (mean age 59 years, F/M 15/12). The proportion of gCJD (E200K mutation) cases remained dominant (78%), with 9 familiar cases originating in 4 families. Analysis of the clinical features revealed shorter duration of the symptomatic phase in sporadic CJD (sCJD) (3.4 months) versus gCJD (5.15 months). Cognitive/behavioural changes, insomnia, and sensory disturbance were more pronounced in the early symptoms of gCJD. Periodic EEG discharges were more frequent in sCJD (83%) than gCJD (56%), all 19 available MR findings were CJD specific and localisation of abnormalities varied amongst the CJD forms. CONCLUSIONS: The surveillance of CJD in ES (2004-2016) showed an increased incidence of CJD in ES, reaching the incidence rate of the whole country, with a permanent proportion of 70% gCJD cases based on the E200K mutation. Clinical, electrophysiological and MR features of sCJD and gCJD cases were in conformity with already published data. Epidemiological analysis of CJD in ES shows increasing detection of CJD but also suggests that current routine surveillance systems for CJD may underestimate the true burden of disease, especially sporadic cases in Slovakia.
1st Private Hospital Kosice Saca Kosice Slovak Republic
Department of Neurology Louis Pasteur University Hospital Kosice Slovak Republic
Department of Prion Diseases Slovak Medical University in Bratislava Bratislava Slovak Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19039804
- 003
- CZ-PrNML
- 005
- 20201116144200.0
- 007
- ta
- 008
- 191112s2018 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.21101/cejph.a5277 $2 doi
- 035 __
- $a (PubMed)30817871
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Feketeová, Eva $7 xx0070674 $u Department of Neurology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice and Louis Pasteur University Hospital, Kosice, Slovak Republic
- 245 10
- $a Creutzfeldt-Jakob disease surveillance in Eastern Slovakia from 2004 to 2016 / $c E. Feketeová, D. Jarčušková, A. Janáková, E. Rozprávková, Z. Cifráková, S. Farkašová-Inaccone, K. Rimárová, E. Dorko, Z. Gdovinová
- 520 9_
- $a OBJECTIVES: An extraordinary incidence of genetic Creutzfeldt-Jakob disease (gCJD) appearing in clusters in the Slovak Republic was described in the 1990's. The aim of the study was to analyse data of CJD cases obtained from surveillance in Eastern Slovakia (ES) (2004-2016), the region outside the described geographical clusters. METHODS: The database set in the project was the source for epidemiological and clinical analysis of CJD cases. RESULTS: The incidence of CJD in ES (2004-2016) was 1.7/million person-years (95% CI 1-2.4); the incidence increase in the last five years (2012-2016) was comparable to the whole country. Twenty seven of 29 reported CJD cases were available for analysis (mean age 59 years, F/M 15/12). The proportion of gCJD (E200K mutation) cases remained dominant (78%), with 9 familiar cases originating in 4 families. Analysis of the clinical features revealed shorter duration of the symptomatic phase in sporadic CJD (sCJD) (3.4 months) versus gCJD (5.15 months). Cognitive/behavioural changes, insomnia, and sensory disturbance were more pronounced in the early symptoms of gCJD. Periodic EEG discharges were more frequent in sCJD (83%) than gCJD (56%), all 19 available MR findings were CJD specific and localisation of abnormalities varied amongst the CJD forms. CONCLUSIONS: The surveillance of CJD in ES (2004-2016) showed an increased incidence of CJD in ES, reaching the incidence rate of the whole country, with a permanent proportion of 70% gCJD cases based on the E200K mutation. Clinical, electrophysiological and MR features of sCJD and gCJD cases were in conformity with already published data. Epidemiological analysis of CJD in ES shows increasing detection of CJD but also suggests that current routine surveillance systems for CJD may underestimate the true burden of disease, especially sporadic cases in Slovakia.
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a skot $7 D002417
- 650 _2
- $a Creutzfeldtova-Jakobova nemoc $x diagnóza $x epidemiologie $x genetika $7 D007562
- 650 12
- $a encefalopatie bovinní spongioformní $7 D016643
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a genotyp $7 D005838
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a incidence $7 D015994
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a mutace $7 D009154
- 650 _2
- $a rodokmen $7 D010375
- 650 _2
- $a surveillance populace $7 D011159
- 650 _2
- $a priony $x genetika $7 D011328
- 651 _2
- $a Slovenská republika $x epidemiologie $7 D018154
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Jarčušková, Dominika $7 xx0241956 $u Department of Neurology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice and Louis Pasteur University Hospital, Kosice, Slovak Republic
- 700 1_
- $a Janáková, Alžbeta $7 xx0241960 $u Department of Prion Diseases, Slovak Medical University in Bratislava, Bratislava, Slovak Republic
- 700 1_
- $a Rozprávková, Eva $7 xx0241939 $u 1st Private Hospital Kosice-Saca, Kosice, Slovak Republic
- 700 1_
- $a Cifráková, Zlatica $7 xx0241935 $u Department of Neurology, Louis Pasteur University Hospital, Kosice, Slovak Republic
- 700 1_
- $a Iannaccone, Silvia $7 xx0105523 $u Department of Forensic Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic
- 700 1_
- $a Rimárová, Kvetoslava, $d 1958- $7 xx0224806 $u Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic
- 700 1_
- $a Dorko, Erik $7 xx0063738 $u Department of Public Health and Hygiene, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Kosice, Slovak Republic
- 700 1_
- $a Gdovinová, Zuzana, $d 1959- $7 xx0240053 $u Department of Neurology, Faculty of Medicine, Pavol Jozef Safarik University in Kosice and Louis Pasteur University Hospital, Kosice, Slovak Republic
- 773 0_
- $w MED00001083 $t Central European journal of public health. Trends in Communicable and Non-communicable Diseases in Eastern Slovakia $x 1210-7778 $g Roč. 26, Suppl. (2018), s. S37-S41
- 773 0_
- $t Trends in communicable and non-communicable diseases in Eastern Slovakia $g (2018), s. S37-S41 $w MED00204324
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30817871 $y Pubmed
- 910 __
- $a ABA008 $b B 1829 $c 562 $y p $z 0
- 990 __
- $a 20191112 $b ABA008
- 991 __
- $a 20201116144158 $b ABA008
- 999 __
- $a ok $b bmc $g 1464365 $s 1078399
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 26 $c Suppl. $d S37-S41 $i 1210-7778 $m Central European Journal of Public Health $n Cent. Eur. J. Public Health $o Trends in Communicable and Non-communicable Diseases in Eastern Slovakia $x MED00001083
- BMC __
- $a 2018 $d S37-S41 $m Trends in communicable and non-communicable diseases in Eastern Slovakia $x MED00204324
- LZP __
- $b NLK118 $a Pubmed-20191112
