• Something wrong with this record ?

Clinical Outcomes of 1625 Patients With Primary Aldosteronism Subtyped With Adrenal Vein Sampling

GP. Rossi, G. Rossitto, L. Amar, M. Azizi, A. Riester, M. Reincke, C. Degenhart, J. Widimsky, M. Naruse, J. Deinum, L. Schultze Kool, T. Kocjan, A. Negro, E. Rossi, G. Kline, A. Tanabe, F. Satoh, L. Christian Rump, O. Vonend, HS. Willenberg, PJ....

. 2019 ; 74 (4) : 800-808. [pub] 20190903

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19044554

We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure, in a large registry of PA patients submitted to AVS. Data of 1625 consecutive patients submitted to AVS in 19 tertiary referral centers located in Asia, Australia, Europe, and North America were collected in a large multicenter international registry. The primary end points were the rate of bilateral success, ascertained lateralization of PA, adrenalectomy, and of cured arterial hypertension among AVS-guided and non AVS-guided adrenalectomy patients. AVS was successful in 80.1% of all cases but allowed identification of unilateral PA in only 45.5% by the criteria in use at each center. Adrenalectomy was performed in 41.8% of all patients and cured arterial hypertension in 19.6% of the patients, 2-fold more frequently in women than men (P<0.001). When AVS-guided, surgery provided a higher rate of cure of hypertension than when non-AVS-guided (40.0% versus 30.5%; P=0.027). Compared with surgical cases, patients treated medically needed more antihypertensive medications (P<0.001) and exhibited a higher rate of persistent hypokalemia requiring potassium supplementation (4.9% versus 2.3%; P<0.01). The low rate of adrenalectomy and cure of hypertension in PA patients seeking surgical cure indicates suboptimal AVS use, possibly related to issues in patient selection, technical success, and AVS data interpretation. Given the better outcomes of AVS-guided adrenalectomy, these results call for actions to improve the diagnostic use of this test that is necessary for detection of surgical PA candidates. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT01234220.

3rd Department of Medicine Charles University Prague General Hospital Czech Republic

AP HP Hôpital Européen Georges Pompidou Hypertension Unit Paris France

Department of Diabetes Endocrinology and Metabolism National Center for Global Health and Medicine

Department of Endocrinology National Hospital Organization Kyoto Medical Center Clinical Research Institute Japan

Department of Internal Medicine

Department of Internal Medicine Azienda Unità Sanitaria Locale IRCCS Arcispedale S Maria Nuova Hypertension Unit Reggio Emilia Italy

Department of Internal Medicine National Taiwan University Hospital Taipei

Department of Medical Imaging National Taiwan University Hospital Taipei

Department of Nephrology Hypertension Unit Hosp del Mar Universitat Autònoma de Barcelona Spain

Department of Nephrology Tohoku University Hospital Endocrinology and Vascular Medicine Sendai

Division of Endocrinology and Metabolism Rostock University Medical Center Germany

Endocrinology in Charlottenburg Berlin Germany

Endocrinology Unit Monash Health Clayton VIC Australia

Foothills Medical Centre University of Calgary Canada

From the Department of Medicine DIMED University of Padova Hypertension Unit University Hospital Padova Italy

Heinrich Heine University Düsseldorf Nephrologie Germany

Institute of Radiology University of Padova Italy

Medical College of Wisconsin Endocrinology Center North Hills Health Center Menomonee Falls

Medizinische Klinik und Poliklinik 4 Klinikum der Universität München LMU München

Radiology

University Medical Centre Ljubljana

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19044554
003      
CZ-PrNML
005      
20200114090300.0
007      
ta
008      
200109s2019 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1161/HYPERTENSIONAHA.119.13463 $2 doi
035    __
$a (PubMed)31476901
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Rossi, Gian Paolo $u From the Department of Medicine-DIMED, University of Padova, Hypertension Unit, University Hospital, Padova, Italy (G.P.R., G.R., P.-E.V., A.C.P.).
245    10
$a Clinical Outcomes of 1625 Patients With Primary Aldosteronism Subtyped With Adrenal Vein Sampling / $c GP. Rossi, G. Rossitto, L. Amar, M. Azizi, A. Riester, M. Reincke, C. Degenhart, J. Widimsky, M. Naruse, J. Deinum, L. Schultze Kool, T. Kocjan, A. Negro, E. Rossi, G. Kline, A. Tanabe, F. Satoh, L. Christian Rump, O. Vonend, HS. Willenberg, PJ. Fuller, J. Yang, NYN. Chee, SB. Magill, Z. Shafigullina, M. Quinkler, A. Oliveras, K. Dun Wu, VC. Wu, Z. Kratka, G. Barbiero, M. Battistel, CC. Chang, PE. Vanderriele, AC. Pessina,
520    9_
$a We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure, in a large registry of PA patients submitted to AVS. Data of 1625 consecutive patients submitted to AVS in 19 tertiary referral centers located in Asia, Australia, Europe, and North America were collected in a large multicenter international registry. The primary end points were the rate of bilateral success, ascertained lateralization of PA, adrenalectomy, and of cured arterial hypertension among AVS-guided and non AVS-guided adrenalectomy patients. AVS was successful in 80.1% of all cases but allowed identification of unilateral PA in only 45.5% by the criteria in use at each center. Adrenalectomy was performed in 41.8% of all patients and cured arterial hypertension in 19.6% of the patients, 2-fold more frequently in women than men (P<0.001). When AVS-guided, surgery provided a higher rate of cure of hypertension than when non-AVS-guided (40.0% versus 30.5%; P=0.027). Compared with surgical cases, patients treated medically needed more antihypertensive medications (P<0.001) and exhibited a higher rate of persistent hypokalemia requiring potassium supplementation (4.9% versus 2.3%; P<0.01). The low rate of adrenalectomy and cure of hypertension in PA patients seeking surgical cure indicates suboptimal AVS use, possibly related to issues in patient selection, technical success, and AVS data interpretation. Given the better outcomes of AVS-guided adrenalectomy, these results call for actions to improve the diagnostic use of this test that is necessary for detection of surgical PA candidates. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT01234220.
650    _2
$a nadledviny $x krevní zásobení $7 D000311
650    12
$a adrenalektomie $7 D000315
650    _2
$a dospělí $7 D000328
650    _2
$a aldosteron $x krev $7 D000450
650    _2
$a odběr vzorku krve $7 D001800
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a hyperaldosteronismus $x krev $x chirurgie $7 D006929
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a výsledek terapie $7 D016896
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Rossitto, Giacomo $u From the Department of Medicine-DIMED, University of Padova, Hypertension Unit, University Hospital, Padova, Italy (G.P.R., G.R., P.-E.V., A.C.P.). Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (G.R.).
700    1_
$a Amar, Laurence $u AP-HP, Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France (L.A., M.A.). Faculty of Medicine, Université de Paris, INSERM, UMR970, Paris-Cardiovascular Research Center, France (L.A.).
700    1_
$a Azizi, Michel $u AP-HP, Hôpital Européen Georges Pompidou, Hypertension Unit, Paris, France (L.A., M.A.). INSERM, CIC1418, F-75015, Paris, France (M.A.).
700    1_
$a Riester, Anna $u Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München (A.R., M.R., C.D.).
700    1_
$a Reincke, Martin $u Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München (A.R., M.R., C.D.).
700    1_
$a Degenhart, Christoph $u Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München (A.R., M.R., C.D.).
700    1_
$a Widimsky, Jiri $u 3rd Department of Medicine, Charles University Prague, General Hospital, Czech Republic (J.W., Z.K.).
700    1_
$a Naruse, Mitsuhide $u Department of Endocrinology, National Hospital Organization Kyoto Medical Center, Clinical Research Institute, Japan (M.N.).
700    1_
$a Deinum, Jaap $u Department of Internal Medicine, (J.D.).
700    1_
$a Schultze Kool, Leo $u Radiology (L.S.K.). Radboud University Medical Center, Nijmegen, Netherlands (L.S.).
700    1_
$a Kocjan, Tomaz $u University Medical Centre Ljubljana (T.K.).
700    1_
$a Negro, Aurelio $u Department of Internal Medicine, Azienda Unità Sanitaria Locale, IRCCS Arcispedale S. Maria Nuova, Hypertension Unit, Reggio Emilia, Italy (A.N., E.R.).
700    1_
$a Rossi, Ermanno $u Department of Internal Medicine, Azienda Unità Sanitaria Locale, IRCCS Arcispedale S. Maria Nuova, Hypertension Unit, Reggio Emilia, Italy (A.N., E.R.).
700    1_
$a Kline, Gregory $u Foothills Medical Centre, University of Calgary, Canada (G.K.).
700    1_
$a Tanabe, Akiyo $u Department of Diabetes, Endocrinology and Metabolism, National Center for Global Health and Medicine (A.T.).
700    1_
$a Satoh, Fumitoshi $u Department of Nephrology, Tohoku University Hospital, Endocrinology and Vascular Medicine, Sendai (F.S.).
700    1_
$a Christian Rump, Lars $u Heinrich Heine University Düsseldorf, Nephrologie, Germany (L.C.R., O.V.).
700    1_
$a Vonend, Oliver $u Heinrich Heine University Düsseldorf, Nephrologie, Germany (L.C.R., O.V.).
700    1_
$a Willenberg, Holger S $u Division of Endocrinology and Metabolism, Rostock University Medical Center, Germany (H.S.W.).
700    1_
$a Fuller, Peter J $u Endocrinology Unit, Monash Health, Clayton, VIC, Australia (P.J.F., J.Y., N.Y.N.C.).
700    1_
$a Yang, Jun $u Endocrinology Unit, Monash Health, Clayton, VIC, Australia (P.J.F., J.Y., N.Y.N.C.).
700    1_
$a Chee, Nicholas Yong Nian $u Endocrinology Unit, Monash Health, Clayton, VIC, Australia (P.J.F., J.Y., N.Y.N.C.).
700    1_
$a Magill, Steven B $u Medical College of Wisconsin, Endocrinology Center, North Hills Health Center, Menomonee Falls (S.B.M.).
700    1_
$a Shafigullina, Zulfiya
700    1_
$a Quinkler, Marcus $u Endocrinology in Charlottenburg, Berlin, Germany (M.Q.).
700    1_
$a Oliveras, Anna $u Department of Nephrology, Hypertension Unit, Hosp. del Mar Universitat Autònoma de Barcelona, Spain (A.O.).
700    1_
$a Dun Wu, Kwan $u Department of Internal Medicine, National Taiwan University Hospital, Taipei (K.D.W., V-C.W.).
700    1_
$a Wu, Vin-Cent $u Department of Internal Medicine, National Taiwan University Hospital, Taipei (K.D.W., V-C.W.).
700    1_
$a Kratka, Zusana $u 3rd Department of Medicine, Charles University Prague, General Hospital, Czech Republic (J.W., Z.K.). Department of Endocrinology, North-Western State Medical University named after I.I. Mechnikov, St. Petersburg, Russia (Z.K.).
700    1_
$a Barbiero, Giulio $u Institute of Radiology, University of Padova, Italy (G.B., M.B.).
700    1_
$a Battistel, Michele $u Institute of Radiology, University of Padova, Italy (G.B., M.B.).
700    1_
$a Chang, Chin-Chen $u Department of Medical Imaging, National Taiwan University Hospital, Taipei (C.-C.C.).
700    1_
$a Vanderriele, Paul-Emmanuel $u From the Department of Medicine-DIMED, University of Padova, Hypertension Unit, University Hospital, Padova, Italy (G.P.R., G.R., P.-E.V., A.C.P.).
700    1_
$a Pessina, Achille C $u From the Department of Medicine-DIMED, University of Padova, Hypertension Unit, University Hospital, Padova, Italy (G.P.R., G.R., P.-E.V., A.C.P.).
773    0_
$w MED00002089 $t Hypertension (Dallas, Tex. : 1979) $x 1524-4563 $g Roč. 74, č. 4 (2019), s. 800-808
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31476901 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200109 $b ABA008
991    __
$a 20200114090633 $b ABA008
999    __
$a ok $b bmc $g 1482823 $s 1083227
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 74 $c 4 $d 800-808 $e 20190903 $i 1524-4563 $m Hypertension $n Hypertension $x MED00002089
LZP    __
$a Pubmed-20200109

Find record

Citation metrics

Archiving options