• Je něco špatně v tomto záznamu ?

Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention

H. Pejsova, JA. Hubacek, P. Zemankova, L. Zlatohlavek,

. 2019 ; 127 (10) : 691-696. [pub] 20190306

Jazyk angličtina Země Německo

Typ dokumentu klinické zkoušky, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20006548

INTRODUCTION: Abdominal obesity is a strong cardiometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. AIM: To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. METHODS: 183 paediatric overweight or obese patients (71 boys and 112 girls), aged 7-16 years, were enrolled in a one-month intensive lifestyle intervention programme. Participants reduced their energy intake and engaged in a supervised exercise programme consisting of 5 physical activity units per day. The subjects were examined both before and after the intervention. RESULTS: The mean BMI decrease achieved was-2.38±0.07 kg/m² (P<0.01). The decrease in plasma leptin concentration was-16.59±0.84 ng/mL (P<0.001) and CRP-0.38±0.04 mg/L (P<0.001). Changes in adiponectin concentrations were not statistically significant. The baseline leptin/adiponectin ratio was a significant predictor of decreases in body weight (P<0.005), BMI (P<0.0001) and waist circumference (P<0.05). CONCLUSION: The leptin/adiponectin ratio at baseline may be a useful predictor of results from interventions focused on decreasing BMIs in children/adolescents.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20006548
003      
CZ-PrNML
005      
20200522105938.0
007      
ta
008      
200511s2019 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1055/a-0859-7041 $2 doi
035    __
$a (PubMed)30841005
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Pejsova, Hana $u III. Internal Clinic GUH and First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
245    10
$a Baseline Leptin/Adiponectin Ratio is a Significant Predictor of BMI Changes in Children/Adolescents after Intensive Lifestyle Intervention / $c H. Pejsova, JA. Hubacek, P. Zemankova, L. Zlatohlavek,
520    9_
$a INTRODUCTION: Abdominal obesity is a strong cardiometabolic risk factor that often occurs as early as in childhood. The negative effect of abdominal obesity on the metabolism is partially mediated by changes to the production of the major adipocyte hormones leptin and adiponectin. Leptin/adiponectin imbalance is associated with increased risk of developing obesity and type 2 diabetes mellitus. AIM: To determine whether leptin, adiponectin and the leptin/adiponectin ratio are significant predictors of body weight loss in intensively treated children/adolescents. METHODS: 183 paediatric overweight or obese patients (71 boys and 112 girls), aged 7-16 years, were enrolled in a one-month intensive lifestyle intervention programme. Participants reduced their energy intake and engaged in a supervised exercise programme consisting of 5 physical activity units per day. The subjects were examined both before and after the intervention. RESULTS: The mean BMI decrease achieved was-2.38±0.07 kg/m² (P<0.01). The decrease in plasma leptin concentration was-16.59±0.84 ng/mL (P<0.001) and CRP-0.38±0.04 mg/L (P<0.001). Changes in adiponectin concentrations were not statistically significant. The baseline leptin/adiponectin ratio was a significant predictor of decreases in body weight (P<0.005), BMI (P<0.0001) and waist circumference (P<0.05). CONCLUSION: The leptin/adiponectin ratio at baseline may be a useful predictor of results from interventions focused on decreasing BMIs in children/adolescents.
650    _2
$a adiponektin $x krev $7 D052242
650    _2
$a mladiství $7 D000293
650    12
$a behaviorální terapie $7 D001521
650    12
$a index tělesné hmotnosti $7 D015992
650    _2
$a dítě $7 D002648
650    12
$a cvičení $7 D015444
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a leptin $x krev $7 D020738
650    _2
$a mužské pohlaví $7 D008297
650    12
$a abdominální obezita $x krev $x patologie $x terapie $7 D056128
650    12
$a obezita dětí a dospívajících $x krev $x patologie $x terapie $7 D063766
655    _2
$a klinické zkoušky $7 D016430
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hubacek, Jaroslav A $u Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
700    1_
$a Zemankova, Petra $u Institute of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
700    1_
$a Zlatohlavek, Lukas $u III. Internal Clinic GUH and First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
773    0_
$w MED00009707 $t Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association $x 1439-3646 $g Roč. 127, č. 10 (2019), s. 691-696
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30841005 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200522105936 $b ABA008
999    __
$a ok $b bmc $g 1525406 $s 1096604
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 127 $c 10 $d 691-696 $e 20190306 $i 1439-3646 $m Experimental and clinical endocrinology & diabetes $n Exp Clin Endocrinol Diabetes $x MED00009707
LZP    __
$a Pubmed-20200511
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace