-
Something wrong with this record ?
Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases
D. Vanda, P. Zajdel, M. Soural,
Language English Country France
Document type Journal Article, Review
- MeSH
- Molecular Targeted Therapy MeSH
- Mental Disorders drug therapy MeSH
- Imidazoles chemistry pharmacology therapeutic use MeSH
- Clinical Trials as Topic MeSH
- Humans MeSH
- Ligands MeSH
- Neurodegenerative Diseases drug therapy MeSH
- Pyridines chemistry pharmacology therapeutic use MeSH
- Drug Design * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
This article provides an overview of compounds based on imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine scaffolds, which act as potent ligands of diverse molecular targets localized in the central nervous system. A literature survey revealed that various imidazopyridines can be powerful modulators of several diseases associated with CNS dysfunction including Alzheimer's disease, Parkinson's disease, schizophrenia, depression or sleeping disorders. A description of target enzymes (e.g., β-secretase, γ-secretase, fatty acid amide hydrolase - FAAH, leucine-rich repeat kinase 2 - LRRK2) and selected receptors (e.g., GABA-A, histamine H3, serotonin 5-HT3, 5-HT4, 5-HT6, dopamine D4, adenosine A2A, orexin), modes of action of imidazopyridine-based ligands and their therapeutic importance is discussed.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19044588
- 003
- CZ-PrNML
- 005
- 20200113081027.0
- 007
- ta
- 008
- 200109s2019 fr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ejmech.2019.111569 $2 doi
- 035 __
- $a (PubMed)31404862
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a fr
- 100 1_
- $a Vanda, David $u Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacký University, Hněvotínská 5, 779 00, Olomouc, Czech Republic.
- 245 10
- $a Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases / $c D. Vanda, P. Zajdel, M. Soural,
- 520 9_
- $a This article provides an overview of compounds based on imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-c]pyridine scaffolds, which act as potent ligands of diverse molecular targets localized in the central nervous system. A literature survey revealed that various imidazopyridines can be powerful modulators of several diseases associated with CNS dysfunction including Alzheimer's disease, Parkinson's disease, schizophrenia, depression or sleeping disorders. A description of target enzymes (e.g., β-secretase, γ-secretase, fatty acid amide hydrolase - FAAH, leucine-rich repeat kinase 2 - LRRK2) and selected receptors (e.g., GABA-A, histamine H3, serotonin 5-HT3, 5-HT4, 5-HT6, dopamine D4, adenosine A2A, orexin), modes of action of imidazopyridine-based ligands and their therapeutic importance is discussed.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a klinické zkoušky jako téma $7 D002986
- 650 12
- $a racionální návrh léčiv $7 D015195
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imidazoly $x chemie $x farmakologie $x terapeutické užití $7 D007093
- 650 _2
- $a ligandy $7 D008024
- 650 _2
- $a duševní poruchy $x farmakoterapie $7 D001523
- 650 _2
- $a cílená molekulární terapie $7 D058990
- 650 _2
- $a neurodegenerativní nemoci $x farmakoterapie $7 D019636
- 650 _2
- $a pyridiny $x chemie $x farmakologie $x terapeutické užití $7 D011725
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Zajdel, Paweł $u Department of Medicinal Chemistry, Jagiellonian University Medical College, 9 Medyczna, 30-688, Kraków, Poland. Electronic address: pawel.zajdel@uj.edu.pl.
- 700 1_
- $a Soural, Miroslav $u Department of Organic Chemistry, Faculty of Science, Palacký University, 17. listopadu 12, 771 46, Olomouc, Czech Republic. Electronic address: miroslav.soural@upol.cz.
- 773 0_
- $w MED00001628 $t European journal of medicinal chemistry $x 1768-3254 $g Roč. 181, č. - (2019), s. 111569
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31404862 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200109 $b ABA008
- 991 __
- $a 20200113081359 $b ABA008
- 999 __
- $a ok $b bmc $g 1482857 $s 1083261
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 181 $c - $d 111569 $e 20190731 $i 1768-3254 $m European journal of medicinal chemistry $n Eur J Med Chem $x MED00001628
- LZP __
- $a Pubmed-20200109
