• Je něco špatně v tomto záznamu ?

Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

J. Mužíková, A. Komersová, V. Lochař, L. Vildová, B. Vošoustová, M. Bartoš,

. 2018 ; 68 (3) : 295-311. [pub] 2018Sep01

Jazyk angličtina Země Chorvatsko

Typ dokumentu srovnávací studie, časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19044709

This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19044709
003      
CZ-PrNML
005      
20200113081220.0
007      
ta
008      
200109s2018 ci f 000 0|eng||
009      
AR
024    7_
$a 10.2478/acph-2018-0030 $2 doi
035    __
$a (PubMed)31259696
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ci
100    1_
$a Mužíková, Jitka $u Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic.
245    10
$a Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release / $c J. Mužíková, A. Komersová, V. Lochař, L. Vildová, B. Vošoustová, M. Bartoš,
520    9_
$a This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis. Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.
650    _2
$a celulosa $x chemie $7 D002482
650    _2
$a chemie farmaceutická $x metody $7 D002626
650    _2
$a uvolňování léčiv $7 D065546
650    _2
$a pomocné látky $x chemie $7 D005079
650    _2
$a laktosa $x chemie $7 D007785
650    _2
$a nelineární dynamika $7 D017711
650    _2
$a polyvinylalkohol $x chemie $7 D011142
650    _2
$a kyselina salicylová $x aplikace a dávkování $x chemie $7 D020156
650    _2
$a rozpustnost $7 D012995
650    _2
$a tablety $7 D013607
650    _2
$a farmaceutická technologie $x metody $7 D013678
650    _2
$a pevnost v tahu $7 D013718
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Komersová, Alena $u Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic.
700    1_
$a Lochař, Václav $u Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic.
700    1_
$a Vildová, Lucie $u Department of Pharmaceutical Technology, Charles University, Faculty of Pharmacy in Hradec Králové, Czech Republic.
700    1_
$a Vošoustová, Bára $u Department of Physical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic.
700    1_
$a Bartoš, Martin $u Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, Czech Republic.
773    0_
$w MED00000116 $t Acta pharmaceutica (Zagreb, Croatia) $x 1846-9558 $g Roč. 68, č. 3 (2018), s. 295-311
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31259696 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200109 $b ABA008
991    __
$a 20200113081552 $b ABA008
999    __
$a ok $b bmc $g 1482978 $s 1083382
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 68 $c 3 $d 295-311 $e 2018Sep01 $i 1846-9558 $m Acta pharmaceutica $n Acta Pharm $x MED00000116
LZP    __
$a Pubmed-20200109

Najít záznam

Citační ukazatele

Možnosti archivace