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Use of a new pneumatic system to support capillary microperfusion in surgical wound healing: an animal model
J. Mejzlik, L. Skoloudik, M. Cerny, A. Ryska, V. Radochova, V. Pellantova, V. Chrobok,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
- MeSH
- chirurgická rána terapie MeSH
- design vybavení MeSH
- hojení ran MeSH
- modely nemocí na zvířatech MeSH
- pilotní projekty MeSH
- prasata MeSH
- terapie ran pomocí řízeného podtlaku přístrojové vybavení MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: To test the efficacy of the a developed medical device, based on the principle of mechanical support of capillary microperfusion. METHOD: In this pilot study involving experimental animals, each pig had two standardised surgical wounds. A cuff that delivered pneumatic three-second micropulses was applied to the wound designated as the 'experimental wound'. The pressure inside the cuff was kept at a level <10mmHg so that during the pulse, the pressure would decrease by one third of the established value. The second wound, designated as the 'control wound', was covered with a standard dressing. Over the course of five days, the pressure inside the cuff was monitored. After the five days, the experimental animal was euthanised and two specimens were collected for histological analysis (one sample from each wound site). Wound healing parameters for the experimental and control wounds were examined by a pathologist. The level of statistical significance was set at 0.05. RESULTS: In this study, 10 experimental animals were used. The average pressure in the cuffs was 8.46mmHg (standard deviation: 3.86). No disparities in wound healing were observed in cases of different average pressures in the experimental wound. With respect to wound healing parameters, a statistically significant difference (p<0.05) was found in favour of the experimental wound. The occurrence of histological signs of poor healing was identical in both study wounds. CONCLUSION: The study shows that a device for the support of capillary microperfusion of the surgical wound had a positive effect. It was confirmed that the mechanical support system of capillary microperfusion was safe and reliable.
Citace poskytuje Crossref.org
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- $a Mejzlik, Jan $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
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- $a Use of a new pneumatic system to support capillary microperfusion in surgical wound healing: an animal model / $c J. Mejzlik, L. Skoloudik, M. Cerny, A. Ryska, V. Radochova, V. Pellantova, V. Chrobok,
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- $a OBJECTIVE: To test the efficacy of the a developed medical device, based on the principle of mechanical support of capillary microperfusion. METHOD: In this pilot study involving experimental animals, each pig had two standardised surgical wounds. A cuff that delivered pneumatic three-second micropulses was applied to the wound designated as the 'experimental wound'. The pressure inside the cuff was kept at a level <10mmHg so that during the pulse, the pressure would decrease by one third of the established value. The second wound, designated as the 'control wound', was covered with a standard dressing. Over the course of five days, the pressure inside the cuff was monitored. After the five days, the experimental animal was euthanised and two specimens were collected for histological analysis (one sample from each wound site). Wound healing parameters for the experimental and control wounds were examined by a pathologist. The level of statistical significance was set at 0.05. RESULTS: In this study, 10 experimental animals were used. The average pressure in the cuffs was 8.46mmHg (standard deviation: 3.86). No disparities in wound healing were observed in cases of different average pressures in the experimental wound. With respect to wound healing parameters, a statistically significant difference (p<0.05) was found in favour of the experimental wound. The occurrence of histological signs of poor healing was identical in both study wounds. CONCLUSION: The study shows that a device for the support of capillary microperfusion of the surgical wound had a positive effect. It was confirmed that the mechanical support system of capillary microperfusion was safe and reliable.
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- $a Skoloudik, Lukas $u Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Hradec Kralove, Charles University, Faculty of Medicine in Hradec Kralove, Czech Republic.
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