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Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

F. Zeka, A. Decock, A. Van Goethem, K. Vanderheyden, F. Demuynck, T. Lammens, HH. Helsmoortel, J. Vermeulen, R. Noguera, AP. Berbegall, V. Combaret, G. Schleiermacher, G. Laureys, A. Schramm, JH. Schulte, S. Rahmann, J. Bienertová-Vašků, P....

. 2018 ; 3 (23) : . [pub] 20181206

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19045099

In this study, the circulating miRNome from diagnostic neuroblastoma serum was assessed for identification of noninvasive biomarkers with potential in monitoring metastatic disease. After determining the circulating neuroblastoma miRNome, 743 miRNAs were screened in 2 independent cohorts of 131 and 54 patients. Evaluation of serum miRNA variance in a model testing for tumor stage, MYCN status, age at diagnosis, and overall survival revealed tumor stage as the most significant factor impacting miRNA abundance in neuroblastoma serum. Differential abundance analysis between patients with metastatic and localized disease revealed 9 miRNAs strongly associated with metastatic stage 4 disease in both patient cohorts. Increasing levels of these miRNAs were also observed in serum from xenografted mice bearing human neuroblastoma tumors. Moreover, murine serum miRNA levels were strongly associated with tumor volume. These findings were validated in longitudinal serum samples from metastatic neuroblastoma patients, where the 9 miRNAs were associated with disease burden and treatment response.

Cancer Research Institute Ghent Ghent University Ghent Belgium Department of Pediatric Hematology Oncology and Stem Cell Transplantation Ghent University Hospital Ghent Belgium

Center for Medical Genetics Department of Biomolecular Medicine and

Center for Medical Genetics Department of Biomolecular Medicine and Cancer Research Institute Ghent Ghent University Ghent Belgium

Department of Paediatric Oncology Institut Curie Paris France

Department of Pathology Medical School University of Valencia CIBERONC Madrid Spain

Department of Pathology Medical School University of Valencia CIBERONC Madrid Spain INCLIVA Biomedical Research Institute Valencia Spain

Department of Pediatric Oncology University Hospital Brno Brno Czech Republic

Department of Pediatrics Section of Hematology Oncology Texas Children's Cancer Center Baylor College of Medicine Houston Texas USA

Division of Oncology The Children's Hospital of Philadelphia Philadelphia USA

Genome Informatics Institute of Human Genetics University Hospital Essen University of Duisburg Essen Essen Germany

Laboratoire de Recherche Translationnelle Centre Léon Bérard Lyon France

Molecular Oncology West German Cancer Center University Hospital Essen University of Duisburg Essen Essen Germany

Molecular Oncology West German Cancer Center University Hospital Essen University of Duisburg Essen Essen Germany Pediatric Oncology and Hematology Charité University Medicine Berlin Germany German Cancer Research Center Heidelberg Germany

Pediatric Hematology Oncology Schneider Children's Medical Center of Israel Tel Aviv Israel

Pediatric Oncology and Hematology University Children's Hospital of Cologne Medical Faculty and

Pediatric Oncology and Hematology University Children's Hospital of Cologne Medical Faculty and Center for Molecular Medicine Cologne University of Cologne Cologne Germany

Pédiatrie Hôpital de Jolimont Haine Saint Paul Belgium

References provided by Crossref.org

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