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Influence of the beam profile crosslinking setting on changes in corneal topography and tomography in progressive keratoconus: Preliminary results
R. Herber, KS. Kunert, V. Veliká, E. Spoerl, LE. Pillunat, F. Raiskup,
Language English Country United States
Document type Journal Article
- MeSH
- Time Factors MeSH
- Adult MeSH
- Photochemotherapy methods MeSH
- Photosensitizing Agents therapeutic use MeSH
- Keratoconus diagnosis drug therapy MeSH
- Collagen therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Follow-Up Studies MeSH
- Corneal Pachymetry methods MeSH
- Cross-Linking Reagents therapeutic use MeSH
- Retrospective Studies MeSH
- Riboflavin therapeutic use MeSH
- Cornea pathology MeSH
- Corneal Topography methods MeSH
- Visual Acuity MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included. Group 1 included eyes treated with the higher peripheral intensity profile. Group 2 included eyes treated with the top hat profile. Accelerated CXL was performed based on the modified Dresden protocol (9 mW/cm2, 10 minutes). Corneal-topography and tomography are characterized using the Pentacam Scheimpflug system. RESULTS: The study comprised 45 eyes (25 eyes in Group 1, 20 eyes in Group 2) from 45 patients. The keratometry (K) at the apex (maximum K) decreased significantly from 54.95 diopters (D) ± 6.73 (SD) to 53.21 ± 6.05 D for Group 1 (P < .001) and from 57.29 ± 7.16 D to 56.48 ± 6.88 D for Group 2 (P = .01). In Group 1, flat K (K1) and steep K (K2) decreased significantly after treatment (P < .05). The thinnest corneal thickness decreased significantly by -17.5 ± 21.9 μm (P = .001) in Group 1. In Group 2, no significant flattening was observed in K1 and K2 (P > .05), and the thinnest corneal thickness showed a slight but not significant thinning (P = .097). CONCLUSIONS: In Group 1 (the higher peripheral intensity group), the corneal topographic and tomographic parameters improved significantly after accelerated CXL. The higher peripheral intensity profile effect on keratoconic cornea flattening seemed to be more pronounced compared with the top hat profile.
References provided by Crossref.org
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- $a Herber, Robert $u From the Department of Ophthalmology (Herber, Spoerl, Pillunat, Raiskup), University Hospital Carl Gustav Carus, Dresden, and the Ernst-Abbe-University of Applied Sciences (Kunert), Jena, Germany; Department of Ophthalmology (Veliká, Raiskup), University Hospital Hradec Králové, Charles University, Prague, Czech Republic. Electronic address: robert.herber@uniklinikum-dresden.de.
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- $a Influence of the beam profile crosslinking setting on changes in corneal topography and tomography in progressive keratoconus: Preliminary results / $c R. Herber, KS. Kunert, V. Veliká, E. Spoerl, LE. Pillunat, F. Raiskup,
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- $a PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included. Group 1 included eyes treated with the higher peripheral intensity profile. Group 2 included eyes treated with the top hat profile. Accelerated CXL was performed based on the modified Dresden protocol (9 mW/cm2, 10 minutes). Corneal-topography and tomography are characterized using the Pentacam Scheimpflug system. RESULTS: The study comprised 45 eyes (25 eyes in Group 1, 20 eyes in Group 2) from 45 patients. The keratometry (K) at the apex (maximum K) decreased significantly from 54.95 diopters (D) ± 6.73 (SD) to 53.21 ± 6.05 D for Group 1 (P < .001) and from 57.29 ± 7.16 D to 56.48 ± 6.88 D for Group 2 (P = .01). In Group 1, flat K (K1) and steep K (K2) decreased significantly after treatment (P < .05). The thinnest corneal thickness decreased significantly by -17.5 ± 21.9 μm (P = .001) in Group 1. In Group 2, no significant flattening was observed in K1 and K2 (P > .05), and the thinnest corneal thickness showed a slight but not significant thinning (P = .097). CONCLUSIONS: In Group 1 (the higher peripheral intensity group), the corneal topographic and tomographic parameters improved significantly after accelerated CXL. The higher peripheral intensity profile effect on keratoconic cornea flattening seemed to be more pronounced compared with the top hat profile.
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- $a Spoerl, Eberhard $u From the Department of Ophthalmology (Herber, Spoerl, Pillunat, Raiskup), University Hospital Carl Gustav Carus, Dresden, and the Ernst-Abbe-University of Applied Sciences (Kunert), Jena, Germany; Department of Ophthalmology (Veliká, Raiskup), University Hospital Hradec Králové, Charles University, Prague, Czech Republic.
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- $a Pillunat, Lutz E $u From the Department of Ophthalmology (Herber, Spoerl, Pillunat, Raiskup), University Hospital Carl Gustav Carus, Dresden, and the Ernst-Abbe-University of Applied Sciences (Kunert), Jena, Germany; Department of Ophthalmology (Veliká, Raiskup), University Hospital Hradec Králové, Charles University, Prague, Czech Republic.
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- $a Raiskup, Frederik $u From the Department of Ophthalmology (Herber, Spoerl, Pillunat, Raiskup), University Hospital Carl Gustav Carus, Dresden, and the Ernst-Abbe-University of Applied Sciences (Kunert), Jena, Germany; Department of Ophthalmology (Veliká, Raiskup), University Hospital Hradec Králové, Charles University, Prague, Czech Republic.
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