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Prevalence of Hypertension in Children with Early-Stage ADPKD
L. Massella, D. Mekahli, D. Paripović, L. Prikhodina, N. Godefroid, A. Niemirska, A. Ağbaş, K. Kalicka, A. Jankauskiene, M. Mizerska-Wasiak, AC. Afonso, R. Salomon, G. Deschênes, G. Ariceta, ZB. Özçakar, A. Teixeira, A. Duzova, J. Harambat, T....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
NLK
Free Medical Journals
od 2006 do Před 1 rokem
PubMed Central
od 2008 do Před 1 rokem
Europe PubMed Central
od 2008 do Před 1 rokem
Open Access Digital Library
od 2006-01-01
PubMed
29674338
DOI
10.2215/cjn.11401017
Knihovny.cz E-zdroje
- MeSH
- ambulantní monitorování krevního tlaku MeSH
- dítě MeSH
- hypertenze epidemiologie MeSH
- lidé MeSH
- logistické modely MeSH
- mladiství MeSH
- polycystické ledviny autozomálně dominantní komplikace MeSH
- prevalence MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
BACKGROUND AND OBJECTIVES: Autosomal dominant polycystic kidney disease is the most common inheritable kidney disease, frequently thought to become symptomatic in adulthood. However, patients with autosomal dominant polycystic kidney disease may develop signs or symptoms during childhood, in particular hypertension. Although ambulatory BP monitoring is the preferred method to diagnose hypertension in pediatrics, data in children with autosomal dominant polycystic kidney disease are limited. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Our retrospective multicenter study was conducted to collect ambulatory BP monitoring recordings from patients with autosomal dominant polycystic kidney disease age <18 years old. Basic anthropometric parameters as well as data on kidney function, BP treatment, and kidney ultrasound were also collected. RESULTS: Data from 310 children with autosomal dominant polycystic kidney disease with a mean age of 11.5±4.1 years old were collected at 22 European centers. At the time when ambulatory BP monitoring was performed, 95% of children had normal kidney function. Reference data for ambulatory BP monitoring were available for 292 patients. The prevalence rates of children with hypertension and/or those who were treated with antihypertensive drugs were 31%, 42%, and 35% during daytime, nighttime, or the entire 24-hour cycle, respectively. In addition, 52% of participants lacked a physiologic nocturnal BP dipping, and 18% had isolated nocturnal hypertension. Logistic regression analysis showed a significant association between a categorical cyst score that was calculated on the basis of the number of cysts >1 cm per kidney and daytime hypertension (odds ratio, 1.70; 95% confidence interval, 1.21 to 2.4; P=0.002), nighttime hypertension (odds ratio, 1.31; 95% confidence interval, 1.05 to 1.63; P=0.02), or 24-hour hypertension (odds ratio, 1.39; 95% confidence interval, 1.08 to 1.81; P=0.01). Kidney length, expressed as SD score, was also significantly associated with nighttime hypertension (odds ratio, 1.23; 95% confidence interval, 1.06 to 1.42; P=0.10). CONCLUSIONS: These data indicate high prevalence of hypertension in children with autosomal dominant polycystic kidney disease starting at young ages.
Department of Pediatric Nephrology Medical University in Lublin Lublin Poland
Department of Pediatrics and Nephrology Medical University of Warsaw Warsaw Poland
Division of Nephrology Department of Pediatric Subspecialties and
Institute of Clinical Medicine Vilnius University Vilnius Lithuania
Institute of Physiology University of Zurich Zurich Switzerland
Nephrology Department University Children's Hospital Belgrade Serbia
Pediatric Nephrology Department Fundeni Clinical Institute Bucharest Romania
Pediatric Nephrology Unit Centro Hospitalar São João Porto Portugal
Citace poskytuje Crossref.org
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