• Something wrong with this record ?

Stereotactic radiosurgery for jugular foramen schwannomas: an international multicenter study

H. Kano, A. Meola, HC. Yang, WY. Guo, R. Martínez-Alvarez, N. Martínez-Moreno, D. Urgosik, R. Liscak, O. Cohen-Inbar, J. Sheehan, JYK. Lee, M. Abbassy, GH. Barnett, D. Mathieu, D. Kondziolka, LD. Lunsford,

. 2018 ; 129 (4) : 928-936. [pub] 20171110

Language English Country United States

Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19045588

OBJECTIVE: For some jugular foramen schwannomas (JFSs), complete resection is possible but may be associated with significant morbidity. Stereotactic radiosurgery (SRS) is a minimally invasive alternative or adjunct to microsurgery for JFSs. The authors reviewed clinical and imaging outcomes of SRS for patients with these tumors. METHODS: Nine participating centers of the International Gamma Knife Research Foundation identified 92 patients who underwent SRS between 1990 and 2013. Forty-one patients had prior subtotal microsurgical resection. The median interval between previous surgery and SRS was 15 months (range 0.5-144 months). Eighty-four patients had preexisting cranial nerve (CN) symptoms and signs. The median tumor volume was 4.1 cm3 (range 0.8-22.6 cm3), and the median margin dose was 12.5 Gy (range 10-18 Gy). Patients with neurofibromatosis were excluded from this study. RESULTS: The median follow-up was 51 months (range 6-266 months). Tumors regressed in 47 patients, remained stable in 33, and progressed in 12. The progression-free survival (PFS) was 93% at 3 years, 87% at 5 years, and 82% at 10 years. In the entire series, only a dumbbell shape (extension extracranially via the jugular foramen) was significantly associated with worse PFS. In the group of patients without prior microsurgery (n = 51), factors associated with better PFS included tumor volume < 6 cm3 (p = 0.037) and non-dumbbell-shaped tumors (p = 0.015). Preexisting cranial neuropathies improved in 27 patients, remained stable in 51, and worsened in 14. The CN function improved after SRS in 12% of patients at 1 year, 24% at 2 years, 27% at 3 years, and 32% at 5 years. Symptomatic adverse radiation effects occurred in 7 patients at a median of 7 months after SRS (range 5-38 months). Six patients underwent repeat SRS at a median of 64 months (range 44-134 months). Four patients underwent resection at a median of 14 months after SRS (range 8-30 months). CONCLUSIONS: Stereotactic radiosurgery proved to be a safe and effective primary or adjuvant management approach for JFSs. Long-term tumor control rates and stability or improvement in CN function were confirmed.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19045588
003      
CZ-PrNML
005      
20200115091254.0
007      
ta
008      
200109s2018 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.3171/2017.5.JNS162894 $2 doi
035    __
$a (PubMed)29125412
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Kano, Hideyuki $u 1Department of Neurological Surgery, Center for Image-guided Neurosurgery, University of Pittsburgh, Pennsylvania.
245    10
$a Stereotactic radiosurgery for jugular foramen schwannomas: an international multicenter study / $c H. Kano, A. Meola, HC. Yang, WY. Guo, R. Martínez-Alvarez, N. Martínez-Moreno, D. Urgosik, R. Liscak, O. Cohen-Inbar, J. Sheehan, JYK. Lee, M. Abbassy, GH. Barnett, D. Mathieu, D. Kondziolka, LD. Lunsford,
520    9_
$a OBJECTIVE: For some jugular foramen schwannomas (JFSs), complete resection is possible but may be associated with significant morbidity. Stereotactic radiosurgery (SRS) is a minimally invasive alternative or adjunct to microsurgery for JFSs. The authors reviewed clinical and imaging outcomes of SRS for patients with these tumors. METHODS: Nine participating centers of the International Gamma Knife Research Foundation identified 92 patients who underwent SRS between 1990 and 2013. Forty-one patients had prior subtotal microsurgical resection. The median interval between previous surgery and SRS was 15 months (range 0.5-144 months). Eighty-four patients had preexisting cranial nerve (CN) symptoms and signs. The median tumor volume was 4.1 cm3 (range 0.8-22.6 cm3), and the median margin dose was 12.5 Gy (range 10-18 Gy). Patients with neurofibromatosis were excluded from this study. RESULTS: The median follow-up was 51 months (range 6-266 months). Tumors regressed in 47 patients, remained stable in 33, and progressed in 12. The progression-free survival (PFS) was 93% at 3 years, 87% at 5 years, and 82% at 10 years. In the entire series, only a dumbbell shape (extension extracranially via the jugular foramen) was significantly associated with worse PFS. In the group of patients without prior microsurgery (n = 51), factors associated with better PFS included tumor volume < 6 cm3 (p = 0.037) and non-dumbbell-shaped tumors (p = 0.015). Preexisting cranial neuropathies improved in 27 patients, remained stable in 51, and worsened in 14. The CN function improved after SRS in 12% of patients at 1 year, 24% at 2 years, 27% at 3 years, and 32% at 5 years. Symptomatic adverse radiation effects occurred in 7 patients at a median of 7 months after SRS (range 5-38 months). Six patients underwent repeat SRS at a median of 64 months (range 44-134 months). Four patients underwent resection at a median of 14 months after SRS (range 8-30 months). CONCLUSIONS: Stereotactic radiosurgery proved to be a safe and effective primary or adjuvant management approach for JFSs. Long-term tumor control rates and stability or improvement in CN function were confirmed.
650    _2
$a mladiství $7 D000293
650    _2
$a dospělí $7 D000328
650    _2
$a senioři $7 D000368
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a následné studie $7 D005500
650    _2
$a tumor glomus jugulare $x diagnostické zobrazování $x mortalita $x chirurgie $7 D005925
650    _2
$a nádory hlavy a krku $x diagnostické zobrazování $x mortalita $x chirurgie $7 D006258
650    _2
$a lidé $7 D006801
650    _2
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mikrochirurgie $x metody $7 D008866
650    _2
$a lidé středního věku $7 D008875
650    _2
$a reziduální nádor $x mortalita $x chirurgie $7 D018365
650    _2
$a neurilemom $x diagnostické zobrazování $x mortalita $x chirurgie $7 D009442
650    _2
$a doba přežití bez progrese choroby $7 D000077982
650    _2
$a radiochirurgie $x metody $7 D016634
650    _2
$a reoperace $7 D012086
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a multicentrická studie $7 D016448
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Meola, Antonio $u 1Department of Neurological Surgery, Center for Image-guided Neurosurgery, University of Pittsburgh, Pennsylvania.
700    1_
$a Yang, Huai-Che $u 2Departments of Radiation Oncology and Neurological Surgery, Taipei Veterans Hospital, Taipei, Taiwan.
700    1_
$a Guo, Wan-Yuo $u 2Departments of Radiation Oncology and Neurological Surgery, Taipei Veterans Hospital, Taipei, Taiwan.
700    1_
$a Martínez-Alvarez, Roberto $u 3Functional and Radiosurgery Unit, Ruber International Hospital, Madrid, Spain.
700    1_
$a Martínez-Moreno, Nuria $u 3Functional and Radiosurgery Unit, Ruber International Hospital, Madrid, Spain.
700    1_
$a Urgosik, Dusan $u 4Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic.
700    1_
$a Liscak, Roman $u 4Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, Prague, Czech Republic.
700    1_
$a Cohen-Inbar, Or $u 5Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia.
700    1_
$a Sheehan, Jason $u 5Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia.
700    1_
$a Lee, John Y K $u 6Department of Neurological Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
700    1_
$a Abbassy, Mahmoud $u 7Department of Neurological Surgery, Cleveland Clinic, Cleveland, Ohio.
700    1_
$a Barnett, Gene H $u 7Department of Neurological Surgery, Cleveland Clinic, Cleveland, Ohio.
700    1_
$a Mathieu, David $u 8Université de Sherbrooke, Centre de Recherche Clinique Étienne-LeBel, Sherbrooke, Quebec, Canada; and.
700    1_
$a Kondziolka, Douglas $u 9New York University Langone Medical Center, New York, New York.
700    1_
$a Lunsford, L Dade $u 1Department of Neurological Surgery, Center for Image-guided Neurosurgery, University of Pittsburgh, Pennsylvania.
773    0_
$w MED00002843 $t Journal of neurosurgery $x 1933-0693 $g Roč. 129, č. 4 (2018), s. 928-936
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29125412 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200109 $b ABA008
991    __
$a 20200115091628 $b ABA008
999    __
$a ok $b bmc $g 1483856 $s 1084261
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 129 $c 4 $d 928-936 $e 20171110 $i 1933-0693 $m Journal of neurosurgery $n J Neurosurg $x MED00002843
LZP    __
$a Pubmed-20200109
Back

Find record

Citation metrics

Archiving options