-
Je něco špatně v tomto záznamu ?
The Basal Ganglia Striosomes Affect the Modulation of Conflicts by Subliminal Information-Evidence from X-Linked Dystonia Parkinsonism
C. Beste, M. Mückschel, R. Rosales, A. Domingo, L. Lee, A. Ng, C. Klein, A. Münchau,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
28505262
DOI
10.1093/cercor/bhx125
Knihovny.cz E-zdroje
- MeSH
- analýza rozptylu MeSH
- antiparkinsonika terapeutické užití MeSH
- bazální ganglia patofyziologie MeSH
- dospělí MeSH
- dystonické poruchy farmakoterapie patologie patofyziologie psychologie MeSH
- elektroencefalografie MeSH
- evokované potenciály fyziologie MeSH
- funkční lateralita MeSH
- genetické nemoci vázané na chromozom X farmakoterapie patologie patofyziologie psychologie MeSH
- konflikt (psychologie) * MeSH
- lidé středního věku MeSH
- lidé MeSH
- mapování mozku MeSH
- mozkové vlny fyziologie MeSH
- psychomotorický výkon fyziologie MeSH
- reakční čas fyziologie MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Cognitive control is relevant when distracting information induces behavioral conflicts. Such conflicts can be produced consciously and by subliminally processed information. Interestingly, both sources of conflict interact suggesting that they share neural mechanisms. Here, we ask whether conjoint effects between different sources of conflict are modulated by microstructural basal ganglia dysfunction. To this end, we carried out an electroencephalography study and examined event-related potentials (ERPs) including source localization using a combined flanker-subliminal priming task in patients with X-linked dystonia Parkinsonism (XDP) and a group of healthy controls. XDP in its early stages is known to predominantly affect the basal ganglia striosomes. The results suggest that conjoint effects between subliminal and conscious sources of conflicts are modulated by the striosomes and were stronger in XDP patients. The neurophysiological data indicate that this effect is related to modulations in conflict monitoring and response selection (N2 ERP) mechanisms engaging the anterior cingulate cortex. Bottom-up perceptual gating, attentional selection, and motor response activation processes in response to the stimuli (P1, N1, and lateralized readiness potential ERPs) were unaffected. Taken together, these data indicate that striosomes modulate the processing of conscious and subliminal sources of conflict suggesting that microstructural basal ganglia properties are relevant for cognitive control.
Faculty of Neurology and Psychiatry University of Santo Tomas España Boulevard Manila Philippines
Institute of Neurogenetics University of Lübeck Maria Goeppert Straße 1 Lübeck Germany
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19045613
- 003
- CZ-PrNML
- 005
- 20200526101124.0
- 007
- ta
- 008
- 200109s2018 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/cercor/bhx125 $2 doi
- 035 __
- $a (PubMed)28505262
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Beste, Christian $u Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, Dresden, Germany. Experimental Neurobiology, National Institute of Mental Health, Topolova 748, Klecany, Czech Republic.
- 245 14
- $a The Basal Ganglia Striosomes Affect the Modulation of Conflicts by Subliminal Information-Evidence from X-Linked Dystonia Parkinsonism / $c C. Beste, M. Mückschel, R. Rosales, A. Domingo, L. Lee, A. Ng, C. Klein, A. Münchau,
- 520 9_
- $a Cognitive control is relevant when distracting information induces behavioral conflicts. Such conflicts can be produced consciously and by subliminally processed information. Interestingly, both sources of conflict interact suggesting that they share neural mechanisms. Here, we ask whether conjoint effects between different sources of conflict are modulated by microstructural basal ganglia dysfunction. To this end, we carried out an electroencephalography study and examined event-related potentials (ERPs) including source localization using a combined flanker-subliminal priming task in patients with X-linked dystonia Parkinsonism (XDP) and a group of healthy controls. XDP in its early stages is known to predominantly affect the basal ganglia striosomes. The results suggest that conjoint effects between subliminal and conscious sources of conflicts are modulated by the striosomes and were stronger in XDP patients. The neurophysiological data indicate that this effect is related to modulations in conflict monitoring and response selection (N2 ERP) mechanisms engaging the anterior cingulate cortex. Bottom-up perceptual gating, attentional selection, and motor response activation processes in response to the stimuli (P1, N1, and lateralized readiness potential ERPs) were unaffected. Taken together, these data indicate that striosomes modulate the processing of conscious and subliminal sources of conflict suggesting that microstructural basal ganglia properties are relevant for cognitive control.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a analýza rozptylu $7 D000704
- 650 _2
- $a antiparkinsonika $x terapeutické užití $7 D000978
- 650 _2
- $a bazální ganglia $x patofyziologie $7 D001479
- 650 _2
- $a mapování mozku $7 D001931
- 650 _2
- $a mozkové vlny $x fyziologie $7 D058256
- 650 12
- $a konflikt (psychologie) $7 D003220
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a dystonické poruchy $x farmakoterapie $x patologie $x patofyziologie $x psychologie $7 D020821
- 650 _2
- $a elektroencefalografie $7 D004569
- 650 _2
- $a evokované potenciály $x fyziologie $7 D005071
- 650 _2
- $a funkční lateralita $7 D007839
- 650 _2
- $a genetické nemoci vázané na chromozom X $x farmakoterapie $x patologie $x patofyziologie $x psychologie $7 D040181
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a psychomotorický výkon $x fyziologie $7 D011597
- 650 _2
- $a reakční čas $x fyziologie $7 D011930
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Mückschel, Moritz $u Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, Dresden, Germany.
- 700 1_
- $a Rosales, Raymond $u XDP Study Group, Philippine Children's Medical Center, Quezon Avenue Corner Agham Road, Quezon City, Manila, Philippines.
- 700 1_
- $a Domingo, Aloysius $u Institute of Neurogenetics, University of Lübeck, Maria-Goeppert-Straße 1, Lübeck, Germany.
- 700 1_
- $a Lee, Lillian $u Faculty of Neurology and Psychiatry, University of Santo Tomas, España Boulevard, Manila, Philippines.
- 700 1_
- $a Ng, Arlene $u XDP Study Group, Philippine Children's Medical Center, Quezon Avenue Corner Agham Road, Quezon City, Manila, Philippines.
- 700 1_
- $a Klein, Christine $u Institute of Neurogenetics, University of Lübeck, Maria-Goeppert-Straße 1, Lübeck, Germany.
- 700 1_
- $a Münchau, Alexander $u Institute of Neurogenetics, University of Lübeck, Maria-Goeppert-Straße 1, Lübeck, Germany.
- 773 0_
- $w MED00006290 $t Cerebral cortex (New York, N.Y. : 1991) $x 1460-2199 $g Roč. 28, č. 7 (2018), s. 2243-2252
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28505262 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200109 $b ABA008
- 991 __
- $a 20200526101121 $b ABA008
- 999 __
- $a ok $b bmc $g 1483881 $s 1084286
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 28 $c 7 $d 2243-2252 $e 20180701 $i 1460-2199 $m Cerebral cortex $n Cereb Cortex $x MED00006290
- LZP __
- $a Pubmed-20200109
