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The Basal Ganglia Striosomes Affect the Modulation of Conflicts by Subliminal Information-Evidence from X-Linked Dystonia Parkinsonism
C. Beste, M. Mückschel, R. Rosales, A. Domingo, L. Lee, A. Ng, C. Klein, A. Münchau,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1996 to 1 year ago
Open Access Digital Library
from 1996-01-01
PubMed
28505262
DOI
10.1093/cercor/bhx125
Knihovny.cz E-resources
- MeSH
- Analysis of Variance MeSH
- Antiparkinson Agents therapeutic use MeSH
- Basal Ganglia physiopathology MeSH
- Adult MeSH
- Dystonic Disorders drug therapy pathology physiopathology psychology MeSH
- Electroencephalography MeSH
- Evoked Potentials physiology MeSH
- Functional Laterality MeSH
- Genetic Diseases, X-Linked drug therapy pathology physiopathology psychology MeSH
- Conflict, Psychological * MeSH
- Middle Aged MeSH
- Humans MeSH
- Brain Mapping MeSH
- Brain Waves physiology MeSH
- Psychomotor Performance physiology MeSH
- Reaction Time physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Cognitive control is relevant when distracting information induces behavioral conflicts. Such conflicts can be produced consciously and by subliminally processed information. Interestingly, both sources of conflict interact suggesting that they share neural mechanisms. Here, we ask whether conjoint effects between different sources of conflict are modulated by microstructural basal ganglia dysfunction. To this end, we carried out an electroencephalography study and examined event-related potentials (ERPs) including source localization using a combined flanker-subliminal priming task in patients with X-linked dystonia Parkinsonism (XDP) and a group of healthy controls. XDP in its early stages is known to predominantly affect the basal ganglia striosomes. The results suggest that conjoint effects between subliminal and conscious sources of conflicts are modulated by the striosomes and were stronger in XDP patients. The neurophysiological data indicate that this effect is related to modulations in conflict monitoring and response selection (N2 ERP) mechanisms engaging the anterior cingulate cortex. Bottom-up perceptual gating, attentional selection, and motor response activation processes in response to the stimuli (P1, N1, and lateralized readiness potential ERPs) were unaffected. Taken together, these data indicate that striosomes modulate the processing of conscious and subliminal sources of conflict suggesting that microstructural basal ganglia properties are relevant for cognitive control.
Faculty of Neurology and Psychiatry University of Santo Tomas España Boulevard Manila Philippines
Institute of Neurogenetics University of Lübeck Maria Goeppert Straße 1 Lübeck Germany
References provided by Crossref.org
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- $a Beste, Christian $u Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, Dresden, Germany. Experimental Neurobiology, National Institute of Mental Health, Topolova 748, Klecany, Czech Republic.
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