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Transection of inferior alveolar nerve in the rat – neuroanatomical study and experimental model [Přerušení nervus alveolaris inferior u potkana - neuroanatomická studie a experimentální model]
I. Němec, V. Smrčka, J. Mazánek, J. Pokorný
Jazyk angličtina Země Česko
- MeSH
- nervus mandibularis * anatomie a histologie chirurgie MeSH
- neuroanatomické techniky pro zobrazení nervových drah MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
Objective. Experimental lesions in the inferior alveolar nerve (IAN) are used for the study of peripheral and central alterations. The objective of our study was to contribute to a more precise description of the approach to the IAN and creating a lesion. Material and methods. Twenty-six males of Wistar laboratory rats were used for the study. The animals were divided into three groups: control group (6 rats), experimental group (12 rats - a part of the bone above the mandibular canal was removed under general anaesthesia using extraoral approach, after exposing a part of the IAN, the nerve was excised in a length of 3 mm), and a sham group (8 rats - the nerve was only dissected but not transected). Persisting denervation was verified using surgical revision and histological and immunohistochemical analysis after the observation period (4 weeks). Results. No evidence of re-innervation after 4 weeks. We found no statistically significant differences in mean weight gains between individual groups during the observation period. Conclusion. The described technique used in the study is one of the possible ways to create a nerve lesion at the site of the main trunk of the nerve. At the same time, the study provides a more precise description of the anatomical situation and approach to the IAN in the mandibular canal.
Přerušení nervus alveolaris inferior u potkana - neuroanatomická studie a experimentální model
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- $a Němec, Ivo $u Charles University, Third Faculty of Medicine, and the Military University Hospital Prague, Department of, Otorhinolaryngology and Maxillofacial Surgery, Prague, Czech Republic $7 xx0209093
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- $a Přerušení nervus alveolaris inferior u potkana - neuroanatomická studie a experimentální model
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- $a Objective. Experimental lesions in the inferior alveolar nerve (IAN) are used for the study of peripheral and central alterations. The objective of our study was to contribute to a more precise description of the approach to the IAN and creating a lesion. Material and methods. Twenty-six males of Wistar laboratory rats were used for the study. The animals were divided into three groups: control group (6 rats), experimental group (12 rats - a part of the bone above the mandibular canal was removed under general anaesthesia using extraoral approach, after exposing a part of the IAN, the nerve was excised in a length of 3 mm), and a sham group (8 rats - the nerve was only dissected but not transected). Persisting denervation was verified using surgical revision and histological and immunohistochemical analysis after the observation period (4 weeks). Results. No evidence of re-innervation after 4 weeks. We found no statistically significant differences in mean weight gains between individual groups during the observation period. Conclusion. The described technique used in the study is one of the possible ways to create a nerve lesion at the site of the main trunk of the nerve. At the same time, the study provides a more precise description of the anatomical situation and approach to the IAN in the mandibular canal.
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