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Genetically Determined Height and Risk of Non-hodgkin Lymphoma
A. Moore, E. Kane, Z. Wang, OA. Panagiotou, LR. Teras, A. Monnereau, N. Wong Doo, MJ. Machiela, CF. Skibola, SL. Slager, G. Salles, NJ. Camp, PM. Bracci, A. Nieters, RCH. Vermeulen, J. Vijai, KE. Smedby, Y. Zhang, CM. Vajdic, W. Cozen, JJ....
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
PubMed Central
od 2011
Europe PubMed Central
od 2011
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
PubMed
32064237
DOI
10.3389/fonc.2019.01539
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
Bill Lyons Informatics Centre UCL Cancer Institute University College London London United Kingdom
Cancer Epidemiology and Intelligence Division Cancer Council Victoria Melbourne VIC Australia
Cancer Epidemiology Unit University of Oxford Oxford United Kingdom
Center for Chronic Immunodeficiency University Medical Center Freiburg Freiburg im Breisgau Germany
Centre for Big Data Research in Health University of New South Wales Sydney NSW Australia
Department of Environmental Health Sciences Yale School of Public Health New Haven CT United States
Department of Epidemiology Brown School of Public Health Providence RI United States
Department of Health Sciences Research Mayo Clinic Rochester MN United States
Department of Health Sciences University of York York United Kingdom
Department of Immunology Genetics and Pathology Uppsala University Uppsala Sweden
Department of Internal Medicine Huntsman Cancer Institute Salt Lake City UT United States
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda MD United States
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle WA United States
Epidemiology Research Program American Cancer Society Atlanta GA United States
Genomic Epidemiology Group German Cancer Research Center Heidelberg Germany
INSERM U1052 Cancer Research Center of Lyon Centre Léon Bérard Lyon France
Interdisciplinary Department of Medicine University of Bari Bari Italy
International Agency for Research on Cancer Lyon France
International Agency for Research on Cancer World Health Organization Lyon France
Ontario Health Study Toronto ON Canada
School of Nursing and Human Sciences Dublin City University Dublin Ireland
School of Public Health Imperial College London London United Kingdom
The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai New York NY United States
Citace poskytuje Crossref.org
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- $a Genetically Determined Height and Risk of Non-hodgkin Lymphoma / $c A. Moore, E. Kane, Z. Wang, OA. Panagiotou, LR. Teras, A. Monnereau, N. Wong Doo, MJ. Machiela, CF. Skibola, SL. Slager, G. Salles, NJ. Camp, PM. Bracci, A. Nieters, RCH. Vermeulen, J. Vijai, KE. Smedby, Y. Zhang, CM. Vajdic, W. Cozen, JJ. Spinelli, H. Hjalgrim, GG. Giles, BK. Link, J. Clavel, AA. Arslan, MP. Purdue, LF. Tinker, D. Albanes, GM. Ferri, TM. Habermann, HO. Adami, N. Becker, Y. Benavente, S. Bisanzi, P. Boffetta, P. Brennan, AR. Brooks-Wilson, F. Canzian, L. Conde, DG. Cox, K. Curtin, L. Foretova, SM. Gapstur, H. Ghesquières, M. Glenn, B. Glimelius, RD. Jackson, Q. Lan, M. Liebow, M. Maynadie, J. McKay, M. Melbye, L. Miligi, RL. Milne, TJ. Molina, LM. Morton, KE. North, K. Offit, M. Padoan, AV. Patel, S. Piro, V. Ravichandran, E. Riboli, S. de Sanjose, RK. Severson, MC. Southey, A. Staines, C. Stewart, RC. Travis, E. Weiderpass, S. Weinstein, T. Zheng, SJ. Chanock, N. Chatterjee, N. Rothman, BM. Birmann, JR. Cerhan, SI. Berndt,
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