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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Arslan, Alan A 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Birmann, Brenda M 1 Bisanzi, Simonetta 1 Boffetta, Paolo 1 Bracci, Paige M 1 Brennan, Paul 1 Brooks-Wilson, Angela R 1 Camp, Nicola J 1 Canzian, Federico 1 Cerhan, James R 1 Chanock, Stephen J 1 Chatterjee, Nilanjan 1 Clavel, Jacqueline 1 Conde, Lucia 1 Cox, David G 1
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Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 CPO Piemonte and Unit of Medical Stat... 1 Cancer Control Research BC Cancer Van... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit University o... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Center for Chronic Immunodeficiency U... 1 Centre for Big Data Research in Healt... 1 Channing Division of Network Medicine... 1 Clinical Genetics Service Department ... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Environmental Health Sc... 1 Department of Epidemiology Brown Scho... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Family Medicine and Pub... 1 Department of Health Sciences Researc... 1 Department of Health Sciences Univers... 1
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Autor
Adami, Hans-Olov 1 Albanes, Demetrius 1 Arslan, Alan A 1 Becker, Nikolaus 1 Benavente, Yolanda 1 Berndt, Sonja I 1 Birmann, Brenda M 1 Bisanzi, Simonetta 1 Boffetta, Paolo 1 Bracci, Paige M 1 Brennan, Paul 1 Brooks-Wilson, Angela R 1 Camp, Nicola J 1 Canzian, Federico 1 Cerhan, James R 1 Chanock, Stephen J 1 Chatterjee, Nilanjan 1 Clavel, Jacqueline 1 Conde, Lucia 1 Cox, David G 1
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Pracoviště
Bill Lyons Informatics Centre UCL Can... 1 CPO Piemonte and Unit of Medical Stat... 1 Cancer Control Research BC Cancer Van... 1 Cancer Epidemiology Research Programm... 1 Cancer Epidemiology Unit University o... 1 Cancer Epidemiology and Intelligence ... 1 Cancer Epidemiology and Intelligence ... 1 Center for Chronic Immunodeficiency U... 1 Centre for Big Data Research in Healt... 1 Channing Division of Network Medicine... 1 Clinical Genetics Service Department ... 1 Department of Cancer Epidemiology and... 1 Department of Computational Biology S... 1 Department of Environmental Health Sc... 1 Department of Epidemiology Brown Scho... 1 Department of Epidemiology University... 1 Department of Epidemiology and Biosta... 1 Department of Family Medicine and Pub... 1 Department of Health Sciences Researc... 1 Department of Health Sciences Univers... 1
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- Moore, Amy
- Kane, Eleanor
- Wang, Zhaoming
- Panagiotou, Orestis A
- Teras, Lauren R
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Monnereau, Alain
Autor Monnereau, Alain Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. Université Paris Descartes, Paris, France. Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux, France
- Wong Doo, Nicole
- Machiela, Mitchell J
- Skibola, Christine F
- Slager, Susan L
NLK
Directory of Open Access Journals
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od 2011
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od 2011
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od 2011-01-01
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od 2011-01-01
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od 2011
PubMed
32064237
DOI
10.3389/fonc.2019.01539
Knihovny.cz E-zdroje
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
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