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Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

K. Strouhalova, M. Přechová, A. Gandalovičová, J. Brábek, M. Gregor, D. Rosel,

. 2020 ; 12 (1) : . [pub] 20200111

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005360

Grantová podpora
18-15684J Grantová Agentura České Republiky
19-03932S Grantová Agentura České Republiky
17-31538A Grantová Agentura České Republiky
LQ1604 Ministerstvo Zdravotnictví Ceské Republiky
CZ.02.1.01/0.0/0.0/16_019/ 0000785 Ministerstvo Zdravotnictví Ceské Republiky
LTC17063 European Cooperation in Science and Technology
NV17-31538A MZ0 CEP - Centrální evidence projektů

Intermediate filaments constitute the third component of the cellular skeleton. Unlike actin and microtubule cytoskeletons, the intermediate filaments are composed of a wide variety of structurally related proteins showing distinct expression patterns in tissues and cell types. Changes in the expression patterns of intermediate filaments are often associated with cancer progression; in particular with phenotypes leading to increased cellular migration and invasion. In this review we will describe the role of vimentin intermediate filaments in cancer cell migration, cell adhesion structures, and metastasis formation. The potential for targeting vimentin in cancer treatment and the development of drugs targeting vimentin will be reviewed.

Citace poskytuje Crossref.org

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$a Strouhalova, Katerina $u Department of Cell Biology, Charles University, Viničná 7, 12843 Prague, Czech Republic. Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University (BIOCEV), Průmyslová 595, 25242 Vestec u Prahy, Czech Republic.
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