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An intrinsically disordered proteins community for ELIXIR

NE. Davey, MM. Babu, M. Blackledge, A. Bridge, S. Capella-Gutierrez, Z. Dosztanyi, R. Drysdale, RJ. Edwards, A. Elofsson, IC. Felli, TJ. Gibson, A. Gutmanas, JM. Hancock, J. Harrow, D. Higgins, CM. Jeffries, P. Le Mercier, B. Mészáros, M. Necci,...

. 2019 ; 8 (-) : . [pub] 20191015

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005631

Grantová podpora
MC_U105185859 Medical Research Council - United Kingdom
U24 HG007822 NHGRI NIH HHS - United States

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled "An intrinsically disordered protein user community proposal for ELIXIR" held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination; integration of IDP data into the ELIXIR Core Data Resources; and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.

BCPL CPERI Centre for Research and Technology Hellas Thessalonica 57001 Greece

Bioinformatics Research Laboratory Department of Biological Sciences University of Cyprus Nicosia CY 1678 Cyprus

Centre for Genomic Regulation Barcelona Spain

Computational Biology Laboratory Danish Cancer Society Research Center Copenhagen 2100 Denmark

Conway Institute of Biomolecular and Biomedical Research University College Dublin Belfield Dublin D4 Ireland

Department of Biochemistry and Biophysics and Science for Life Laboratory Stockholm University Stockholm Sweden

Department of Biochemistry Cardiovascular Research Institute Maastricht Maastricht University Maastricht The Netherlands

Department of Biochemistry Eötvös Loránd University Budapest H 1117 Hungary

Department of Biochemistry University of Zurich Zurich Switzerland

Department of Biomedical Sciences University of Padua Padua Italy

Department of Chemistry and CERM Ugo Schiff University of Florence Florence Italy

Department of Genetics University of Cambridge Cambridge CB2 3EH UK

Department of Structural Biology and the Israel Structural Proteomics Center Weizmann Institute of Science Reḥovot 7610001 Israel

Division of Cancer Biology Institute of Cancer Research UK London SW3 6JB UK

ELIXIR Hub Wellcome Genome Campus Cambridge CB10 1SD UK

European Bioinformatics Institute European Molecular Biology Laboratory Cambridge CB10 1SD UK

European Molecular Biology Laboratory Hamburg Germany

Faculty of Medicine Medizinisches Proteom Center Ruhr University Bochum GesundheitsCampus 4 Bochum 44801 Germany

HES SO HEG and SIB Text Mining Swiss Institute of Bioinformatics Geneva Switzerland

Institut de Biologie Structurale Université Grenoble Alpes Grenoble 38000 France

Institute of Enzymology Research Centre for Natural Sciences of the Hungarian Academy of Sciences Budapest H 1117 Hungary

Institute of Organic Chemistry and Biochemistry CAS Prague Czech Republic

Institute of Structural and Molecular Biology Birkbeck College University of London London WC1H 0HA UK

Life Sciences Department Barcelona Supercomputing Center Barcelona Spain

MRC Laboratory of Molecular Biology Cambridge CB2 0QH UK

Protein Data Bank in Europe European Bioinformatics Institute European Molecular Biology Laboratory Cambridge CB10 1SD UK

School of Biotechnology and Biomolecular Sciences University of New South Wales Sydney NSW Australia

Structural and Computational Biology Unit European Molecular Biology Laboratory Heidelberg Germany

Swiss Prot Group SIB Swiss Institute of Bioinformatics Geneva Switzerland

University of Wisconsin Madison Madison WI 53706 1544 USA

VIB Center for Structural Biology VIB Flemish Institute for Biotechnology Brussels 1050 Belgium

VUB ULB Interuniversity Institute of Bioinformatics in Brussels and Structural Biology Brussels Vrije Universiteit Brussel Brussels B 1050 Belgium

Citace poskytuje Crossref.org

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